Online citations, reference lists, and bibliographies.

A Hybrid Micromixer With Planar Mixing Units

Sajad Razavi Bazaz, Ali Abouei Mehrizi, Sadegh Ghorbani, Steven Vasilescu, Mohsen Asadnia, Majid Ebrahimi Warkiani
Published 2018 · Chemistry
Cite This
Download PDF
Analyze on Scholarcy
Share
The application of microfluidic systems in chemical and biological assays has progressed dramatically in recent years. One of the fundamental operations that microfluidic devices must achieve is a high mixing index. Of particular importance is the role of planar mixing units with repetitive obstacles (MURO) in the formation of micromixers. To date, a myriad of planar passive micromixers has been proposed. However, a strategy for the combination of these units to find an efficient planar mixer has not been investigated. As such, five different MURO have been selected to form a “hybrid micromixer,” and their combination was evaluated via numerical and experimental methods. These mixing units include ellipse-like, Tesla, nozzle and pillar, teardrop, and obstruction in a curved mixing unit. Since these units have distinctive dimensions, dynamic and geometric similarities were used to scale and connect them. Afterwards, six slots were designated to house each mixing unit. Since the evaluation of all possible unit configurations is not feasible, the design of experiment method is applied to reduce the total number of experiments from 15 625 to 25. Following this procedure, the “hybrid” micromixer proposed here, comprising Tesla, nozzle and pillar, and obstruction units, shows improved performance for a wide range of Re (i.e., mixing index of >90% for Re 0.001–0.1, 22–45) over existing designs. The use of velocity profiles, concentration diagrams, vorticity and circulation plots assist in the analysis of each unit. Comparison of the proposed “hybrid” micromixer with other obstacle-based planar micromixers demonstrates improved performance, indicating the combination of planar mixing units is a useful strategy for building high-performance micromixers.
This paper references
10.1016/J.CEJ.2015.10.122
Passive mixers in microfluidic systems: A review
Chia-Yen Lee (2016)
10.1007/978-1-4612-4380-9_23
On the Experimental Attainment of Optimum Conditions
George E. P. Box (1951)
10.1039/c5lc01159k
Fundamentals and applications of inertial microfluidics: a review.
Jun Xiong Zhang (2016)
Biological applications of microfluidics
Frank A. Gomez (2008)
10.1039/b414180f
An easily integrative and efficient micromixer and its application to the spectroscopic detection of glucose-catalyst reactions.
Do-Hyeong Kim (2005)
10.1039/B305892A
A novel in-plane passive microfluidic mixer with modified Tesla structures.
Chien-Chong Hong (2004)
10.1016/J.SNB.2017.12.034
Recent advances and applications of micromixers
Chia-Yen Lee (2018)
10.1088/0960-1317/17/12/016
A rhombic micromixer with asymmetrical flow for enhancing mixing
Chen-Kuei Chung (2007)
10.3390/mi9020070
Optimization of Wavy-Channel Micromixer Geometry Using Taguchi Method †
Nita Solehati (2018)
10.1007/S40092-014-0061-Y
More efficiency in fuel consumption using gearbox optimization based on Taguchi method
Masoud Goharimanesh (2014)
10.1016/j.cej.2008.10.006
Parametric study on mixing of two fluids in a three-dimensional serpentine microchannel
Mubashshir Ahmad Ansari (2009)
10.1088/0964-1726/11/5/306
Optimizing layout of obstacles for enhanced mixing in microchannels
Hengzi Wang (2002)
Taguchi Methods: Orthogonal Arrays and Linear Graphs-Tools for Quality Engineering
G. Taguchi (1987)
10.1007/S00542-013-2040-4
Simulation and fabrication of a branch-channel rhombic micromixer for low pressure drop and short mixing length
Chen-Kuei Chung (2014)
10.18869/ACADPUB.JAFM.73.238.26374
Enhancement of Mixing Performance of Non-Newtonian Fluids using Curving and Grooving of Microchannels
Sima Baheri Islami (2017)
10.1126/science.aaf1389
Submillisecond organic synthesis: Outpacing Fries rearrangement through microfluidic rapid mixing
Heejin Kim (2016)
10.1142/S0219519418500021
SIZE-CONTROLLED DROPLET GENERATION IN A MICROFLUIDIC DEVICE FOR RARE DNA AMPLIFICATION BY OPTIMIZING ITS EFFECTIVE PARAMETERS
Ali Lashkaripour (2018)
10.3390/mi5040913
Mixing Analysis of Passive Micromixer with Unbalanced Three-Split Rhombic Sub-Channels
Shakhawat Hossain (2014)
10.1017/S0021859600003750
Studies in crop variation. I. An examination of the yield of dressed grain from Broadbalk
Rory A. Fisher (1921)
10.1007/s10544-006-9023-5
Mixing enhancement of the passive microfluidic mixer with J-shaped baffles in the tee channel
Yu-Cheng Lin (2007)
10.1007/s10404-007-0197-9
Effect of geometry on fluid mixing of the rhombic micromixers
Chen-Kuei Chung (2008)
10.1016/j.cmpb.2014.05.007
An efficient passive planar micromixer with ellipse-like micropillars for continuous mixing of human blood
Nhut Tran-Minh (2014)
10.1007/S00542-015-2722-1
Design optimization of capillary-driven micromixer with square-wave microchannel for blood plasma mixing
Ju-Nan Kuo (2017)
10.1016/J.CEJ.2012.05.044
Active micromixer using electrokinetic effects in the micro/nanochannel junction
Samuel Yu (2012)
10.1007/S10404-018-2048-2
Desktop micromilled microfluidics
Ali Lashkaripour (2018)
10.1088/0960-1317/17/5/023
A passive planar micromixer with obstructions for mixing at low Reynolds numbers
Ali Asgar S. Bhagat (2007)
Tootoonchi, More efficiency in fuel consumption using gearbox optimization based on Taguchi method
M. Goharimanesh (2014)
10.1016/J.CEJ.2016.11.052
A novel passive micromixer designed by applying an optimization algorithm to the zigzag microchannel
Xueye Chen (2017)
10.1088/0960-1317/14/1/302
Rapid three-dimensional passive rotation micromixer using the breakup process
Sungjin Park (2004)
10.1016/J.MEE.2011.02.115
Design of microfluidic devices for drug screening on in-vitro cells for osteoporosis therapies
Francesca Nason (2011)
10.1007/S00604-011-0567-6
Integrated micro/nano-fluidic system for mixing and preconcentration of dissolved proteins
Khalid Anwar (2011)
10.1007/s11627-016-9786-1
Design of experiments (DOE)—history, concepts, and relevance to in vitro culture
Randall P. Niedz (2016)
10.1088/0960-1317/15/2/R01
Micromixers—a review
Nam-Trung Nguyen (2005)
10.1088/0960-1317/18/8/085005
Enhancing particle dispersion in a passive planar micromixer using rectangular obstacles
Ali Asgar S. Bhagat (2008)
10.1007/S00348-011-1246-4
Experimental investigation of a scaled-up passive micromixer with uneven interdigital inlet and teardrop obstruction elements
K. Cook (2012)
10.1016/J.TET.2015.05.096
Polymerization of vinyl ethers initiated by dendritic cations using flow microreactors
Aiichiro Nagaki (2015)
10.22059/JCAMECH.2015.55101
Numerical Study of Droplet Generation Process in a Microfluidic Flow Focusing
Ali Lashkaripour (2015)
10.1088/0960-1317/9/3/301
Rapid prototyping of microfluidic switches in poly(dimethyl siloxane) and their actuation by electro-osmotic flow
David C Duffy (1999)
10.29252/JAFM.11.01.28110
A Thoroughgoing Design of a Rapid-cycle Microfluidic Droplet-based PCR Device to Amplify Rare DNA Strands
Mina Mollajan (2018)
10.1007/S10404-014-1343-9
Unsteady pulsating characteristics of the fluid flow through a sudden expansion microvalve
Amir Nejat (2014)
Journal of the royal statistical society. series b (methodological)
G E Box (1951)
10.1039/B502031J
Chaotic micromixers using two-layer crossing channels to exhibit fast mixing at low Reynolds numbers.
Haibing Xia (2005)
TRANSPORT OF PARTICLE-LADEN FLUIDS THROUGH FIXED-VALVE MICROPUMPS
Ling-Sheng Jang (1999)
10.1063/1.4974904
An easily fabricated three-dimensional threaded lemniscate-shaped micromixer for a wide range of flow rates.
Mehdi Rafeie (2017)
10.1016/J.SNB.2015.02.048
Computational fluid dynamic analysis of poly(dimethyl siloxane) magnetic actuator based micromixer
Naresh Veldurthi (2015)
10.1016/J.SNB.2011.05.016
DNA ligation using a disposable microfluidic device combined with a micromixer and microchannel reactor
Yong-jun Ko (2011)
10.1016/J.SNB.2012.08.031
Design and test of a passive planar labyrinth micromixer for rapid fluid mixing
Peng Li (2012)
10.1016/J.CEJ.2010.02.002
Analysis and optimization of a micromixer with a modified Tesla structure
Shakhawat Hossain (2010)
10.1039/C7AY00022G
Simulation and experimental analysis of a SAR micromixer with F-shape mixing units
Xueye Chen (2017)
10.1160/TH07-03-0163
Microfluidic reveals generation of platelet-strings on tumor-activated endothelium.
Tobias Goerge (2007)
10.1016/J.CHERD.2013.09.008
Mixing performance of a planar micromixer with circular obstructions in a curved microchannel
Afroz Alam (2014)
10.1063/1.4827598
An effective splitting-and-recombination micromixer with self-rotated contact surface for wide Reynolds number range applications.
Xiangsong Feng (2013)
10.1007/S10404-011-0928-9
Analysis of passive microfluidic mixers incorporating 2D and 3D baffle geometries fabricated using an excimer laser
Kevin Conlisk (2012)



This paper is referenced by
10.1002/elps.201900474
Electrokinetic-vortex formation near a two-part cylinder with same-sign zeta potentials in a straight microchannel.
Chengfa Wang (2020)
10.1039/c8lc01253a
Performance tuning of microfluidic flow-focusing droplet generators.
Ali Lashkaripour (2019)
10.1016/j.cep.2019.107771
Active and passive micromixers: A comprehensive review
Morteza Bayareh (2020)
10.1016/j.ooc.2020.100001
A Rapidly Prototyped Lung-on-a-chip Model Using 3D-Printed Molds
Jesus Shrestha (2019)
10.1177/0954408919862997
Optimal parametric mixing analysis of active and passive micromixers using Taguchi method
Imran Husssain Shah (2019)
10.1038/s41598-020-62569-9
3D Printing of Inertial Microfluidic Devices
Sajad Razavi Bazaz (2020)
10.1016/j.carbpol.2019.115551
Promoted chondrogenesis of hMCSs with controlled release of TGF-β3 via microfluidics synthesized alginate nanogels.
Zahra Mahmoudi (2020)
10.1063/1.5093345
Experimental and numerical study of elasto-inertial focusing in straight channels.
Mohammad Amin Raoufi (2019)
10.1007/s13346-019-00636-z
A simple coating method of PDMS microchip with PTFE for synthesis of dexamethasone-encapsulated PLGA nanoparticles
Zahra Mahmoodi (2019)
10.1039/c9sm02067e
Fabrication of unconventional inertial microfluidic channels using wax 3D printing.
Mohammad Amin Raoufi (2020)
10.1002/9783527818341.ch7
Biological Diagnosis Based on Microfluidics and Nanotechnology
Navid Kashaninejad (2020)
10.1039/c9lc00152b
Rapid separation and identification of beer spoilage bacteria by inertial microfluidics and MALDI-TOF mass spectrometry.
Mark R Condina (2019)
10.3390/mi10120844
Asymmetrical Split-and-Recombine Micromixer with Baffles
Wasim Raza (2019)
10.1002/ADMT.201900425
Rapid Softlithography Using 3D-Printed Molds
Sajad Razavi Bazaz (2019)
10.3390/mi11040440
High-Throughput Particle Concentration Using Complex Cross-Section Microchannels
Asma Mihandoust (2020)
Semantic Scholar Logo Some data provided by SemanticScholar