Online citations, reference lists, and bibliographies.
← Back to Search

Iron Oxide Nanoparticle-induced Hematopoietic And Immunological Response In Rats

Usha Singh Gaharwar, S. Kumar, P. Rajamani
Published 2020 · Chemistry

Cite This
Download PDF
Analyze on Scholarcy
The application and use of iron oxide nanoparticless (IONPs) in the biomedical field are steadily increasing, although it remains uncertain whether IONPs are safe or should be used with caution. In the present study, we investigated the toxicity profile of ultrafine IONPs in rats administered with 7.5, 15 and 30 mg IONPs/kg body wt intravenously once a week for 4 weeks. IONP treatment reduces bone marrow-mononuclear cell proliferation, increases free radical species and DNA damage leading to growth arrest and subsequently apoptosis induction at 15 and 30 mg doses. It also induces apoptosis in undifferentiated hematopoietic stem cells. IONP treatment significantly increased the pro-inflammatory cytokine (Interleukin (IL)-1β, TNF-α, and IL-6) level in serum. The induction in inflammation was likely mediated by splenic M1 macrophages (IL-6 and TNF-α secretion). IONP treatment induces splenocyte apoptosis and alteration in the immune system represented by reduced CD4+/CD8+ ratio and increased B cells. It also reduces innate defense represented by lower natural killer cell cytotoxicity. IONP administration markedly increased lipid peroxidation in the spleen, while the glutathione level was reduced. Similarly, superoxide dismutase activity was increased and catalase activity was reduced in the spleen of IONP-treated rats. At an organ level, IONP treatment did not cause any significant injury or structural alteration in the spleen. Collectively, our results suggest that a high dose of ultrafine IONPs may cause oxidative stress, cell death, and inflammation in a biological system.
This paper references
Synthesis and Characterization of Nontoxic Hollow Iron Oxide α-Fe2O3 Nanoparticles Using a Simple Hydrothermal Strategy
Rabia Riasat (2016)
Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase.
S. Marklund (1974)
Human macrophage responses to metal-oxide nanoparticles: a review
Camila Figueiredo Borgognoni (2018)
Emerging targets for radioprotection and radiosensitization in radiotherapy
S. Kumar (2016)
Biochemical and Molecular Mechanisms of Radioprotective Effects of Naringenin, a Phytochemical from Citrus Fruits.
S. Kumar (2016)
Comparison of the effectiveness of four Budyko-based methods in attributing long-term changes in actual evapotranspiration
Tingting Ning (2018)
Biodistribution, Clearance And Morphological Alterations Of Intravenously Administered Iron Oxide Nanoparticles In Male Wistar Rats
Usha Singh Gaharwar (2019)
Signaling role of iron in NF-kappa B activation in hepatic macrophages
S. Xiong (2004)
Investigating the toxic effects induced by iron oxide nanoparticles on neuroblastoma cell line: an integrative study combining cytotoxic, genotoxic and proteomic tools
Dalel Askri (2019)
Differential cellular responses in healthy mice and in mice with established airway inflammation when exposed to hematite nanoparticles.
Å. Gustafsson (2015)
Metabolomics reveals the role of acetyl-l-carnitine metabolism in γ-Fe2O3 NP-induced embryonic development toxicity via mitochondria damage
Zhenyao Huang (2019)
Are Endothelial Progenitor Cells the Real Solution for Cardiovascular Diseases? Focus on Controversies and Perspectives
C. Balistreri (2015)
Metal-Based Nanoparticles and the Immune System: Activation, Inflammation, and Potential Applications
Yueh-Hsia Luo (2015)
Potential toxicity of superparamagnetic iron oxide nanoparticles (SPION)
N. Singh (2010)
Toxicity evaluation of monodisperse PEGylated magnetic nanoparticles for nanomedicine
Vitalii Patsula (2019)
Iron oxide nanoparticles induced cytotoxicity, oxidative stress and DNA damage in lymphocytes
Usha Singh Gaharwar (2017)
Bottom-up approach synthesis of core-shell nanoscale zerovalent iron (CS-nZVI): Physicochemical and spectroscopic characterization with Cu(II) ions adsorption application
A. O. Dada (2020)
In vivo delivery, pharmacokinetics, biodistribution and toxicity of iron oxide nanoparticles.
H. Arami (2015)
Effects of calmodulin antagonists on radiation-induced lipid peroxidation in microsomes.
R. Varshney (1990)
Role of Macrophage (M1 and M2) in Titanium-Dioxide Nanoparticle-Induced Oxidative Stress and Inflammatory Response in Rat
S. Kumar (2016)
Metabolic fate and subchronic biological effects of core–shell structured Fe3O4@SiO2-NH2 nanoparticles
Yueli Chen (2018)
Molecular liaisons between erythropoiesis and iron metabolism.
Léon Kautz (2014)
Fabrication of BSA-Green Tea Polyphenols-Chitosan Nanoparticles and Their Role in Radioprotection: A Molecular and Biochemical Approach.
S. Kumar (2016)
Comment on ‘endoplasmic reticulum stress mediates inflammatory response triggered by ultra-small superparamagnetic iron oxide nanoparticles in hepatocytes’
Chengyu Yang (2020)
Oxidative stress in gill, erythrocytes, liver and kidney of Nile tilapia (Oreochromis niloticus) from a polluted site
A. Bainy (1996)
Harmful at non-cytotoxic concentrations: SiO2-SPIONs affect surfactant metabolism and lamellar body biogenesis in A549 human alveolar epithelial cells
V. Kononenko (2017)
Proteomic profiling of RAW264.7 macrophage cells exposed to graphene oxide: insights into acute cellular responses
X. Yang (2019)
Catalase in vitro.
H. Aebi (1984)
Cellular interactions of functionalized superparamagnetic iron oxide nanoparticles on oligodendrocytes without detrimental side effects: Cell death induction, oxidative stress and inflammation.
S. Sruthi (2018)
LSK Derived LSK– Cells Have a High Apoptotic Rate Related to Survival Regulation of Hematopoietic and Leukemic Stem Cells
Cong Peng (2012)
Kinetics, mechanism, isotherm and thermodynamic studies of liquid phase adsorption of Pb2+ onto wood activated carbon supported zerovalent iron (WAC-ZVI) nanocomposite
A. O. Dada (2017)
Synthesis and dose interval dependent hepatotoxicity evaluation of intravenously administered polyethylene glycol-8000 coated ultra-small superparamagnetic iron oxide nanoparticle on Wistar rats.
Balan Rajan (2015)
Are iron oxide nanoparticles safe? Current knowledge and future perspectives.
Vanessa Valdiglesias (2016)
In situ immune response and mechanisms of cell damage in central nervous system of fatal cases microcephaly by Zika virus
Raimunda S. S. Azevedo (2017)
Potential toxic effects of iron oxide nanoparticles in in vivo and in vitro experiments
B. Szalay (2012)
Immunological effects of iron oxide nanoparticles and iron-based complex drug formulations: Therapeutic benefits, toxicity, mechanistic insights, and translational considerations.
Ankit Shah (2018)
Assessing cytotoxicity of (iron oxide-based) nanoparticles: an overview of different methods exemplified with cationic magnetoliposomes.
S. Soenen (2009)
Structure and function of the spleen
R. Mebius (2005)
Iron oxide nanoparticles may damage to the neural tissue through iron accumulation, oxidative stress, and protein aggregation
Zahra Yarjanli (2017)
Uptake, distribution, clearance, and toxicity of iron oxide nanoparticles with different sizes and coatings
Qiyi Feng (2018)
Iron Oxide Nanoparticles Induced Oxidative Damage in Peripheral Blood Cells of Rat
Usha Singh Gaharwar (2015)
Folic acid-targeted iron oxide nanoparticles as contrast agents for magnetic resonance imaging of human ovarian cancer
H. Zhang (2016)
Superparamagnetic iron oxide nanoparticle uptake alters M2 macrophage phenotype, iron metabolism, migration and invasion.
J. Rojas (2016)
Corrigendum to “Development of a Doxycycline Hydrochloride-Loaded Electrospun Nanofibrous Membrane for GTR/GBR Applications”
Lie-ni Jia (2016)
Accelerated generation of free radicals by iron oxide nanoparticles in the presence of an alternating magnetic field.
Robert J. Wydra (2015)
Biodistribution and targeting properties of iron oxide nanoparticles for treatments of cancer and iron anemia disease
E. Alphandéry (2019)
Association of High Myopia with Crystallin Beta A4 (CRYBA4) Gene Polymorphisms in the Linkage-Identified MYP6 Locus
D. H. Ho (2012)
Induction of intrinsic apoptotic pathway and cell cycle arrest via baicalein loaded iron oxide nanoparticles as a competent nano-mediated system for triple negative breast cancer therapy
K. Kavithaa (2016)

Semantic Scholar Logo Some data provided by SemanticScholar