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6,7-Dimethyllumazine As A Potential Ligand For Selective Recognition Of Adenine Opposite An Abasic Site In DNA Duplexes.

Zhiqiang Ye, Burki Rajendar, D. Qing, S. Nishizawa, N. Teramae
Published 2008 · Chemistry, Medicine

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6,7-Dimethyllumazine more selectively binds to adenine (A) base opposite the abasic site in DNA duplexes (5'-TCC AGX[combining low line] GCA AC-3'/3'-AGG TCN CGT TG-5', X = AP site (Spacer C3), N= A, T, C and G) than the other three nucleobases with a dissociation constant K(d) of ca. 1.0 microM; substituted methyl groups enhance the binding affinity to A and the selectivity for A over T, compared to the parent molecule, lumazine.
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