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Synthesis Of Ferrocene Tethered Open And Macrocyclic Bis-beta-lactams And Bis-beta-amino Acid Derivatives.

M. Sierra, M. Rodriguez‐Fernandez, Luis Casarrubios, M. Gómez-Gallego, C. P. Allen, M. J. Mancheño
Published 2009 · Chemistry, Medicine

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New bioorganometallic ferrocene derivatives are synthesized through a Diversity Oriented Synthesis strategy. Easily available ferrocene bisimines have been transformed into open ferrocenyl bis-beta-lactams. These compounds have demonstrated to be versatile synthons used in further transformations into new ferrocene bis-beta-amino acids. Carefully selected substituents submitted to ring closing metathesis (RCM) and Cu-catalyzed oxidative alkyne coupling conditions have also allowed the conversion of open substrates into ferrocenic macrocyclic bis-beta-lactams.
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