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Acid-mediated Formation Of Trifluoromethyl Sulfonates From Sulfonic Acids And A Hypervalent Iodine Trifluoromethylating Agent.

R. Koller, Quentin A. Huchet, P. Battaglia, J. Welch, A. Togni
Published 2009 · Chemistry, Medicine

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A variety of sulfonic acids have been trifluoromethylated using 1-trifluoromethyl-1,2-benziodoxol-3(1H)-one under mild conditions in good to excellent yields. Initial mechanistic investigations of this reaction show a clean second-order kinetics and only very weak substrate electronic effects.
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