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Unprecedented Synthesis Of A Novel Amino Quinone Ring System Via Oxidative Decarboxylation Of Quinone-based Alpha,alpha-amino Esters.

P. Campiglia, C. Aquino, A. Bertamino, N. De Simone, M. Sala, S. Castellano, M. Santoriello, P. Grieco, E. Novellino, I. Gomez-Monterrey
Published 2010 · Chemistry, Medicine

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An unusual and efficient method for the synthesis of new quinone-based amine and its derivatives from the corresponding alpha,alpha-amino ester is described. The procedure involves the quinone-based system's oxidative decarboxylation via hydride transfer throughout basic hydrolysis. This synthetic method provides, with good yields, rapid access to new potentially cytotoxic quinones.
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