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Electrophilic Fluorination Using A Hypervalent Iodine Reagent Derived From Fluoride.

Gemma C. Geary, Eric G. Hope, K. Singh, A. M. Stuart
Published 2013 · Chemistry, Medicine

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The air and moisture stable fluoroiodane 8, readily prepared on a 6 g scale by nucleophilic fluorination of the hydroxyiodane 7 with TREAT-HF, has been used as an electrophilic fluorinating reagent for the first time to monofluorinate 1,3-ketoesters and difluorinate 1,3-diketones in good isolated yields.
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