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2,4-Diamino-6,7-dimethylpteridine As A Fluorescent Ligand For Binding And Sensing An Orphan Cytosine In RNA Duplexes.
Y. Sato, Y. Toriyabe, S. Nishizawa, N. Teramae
Published 2013 · Chemistry, Medicine
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We report on a new fluorescent ligand, 2,4-diamino-6,7-dimethylpteridine, that can strongly and selectively bind to an orphan cytosine opposite an abasic site in RNA duplexes. We describe a significant effect of the substituents attached to the pteridine ring on the binding behavior in comparison with a structurally-similar pteridine derivative.
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