(E)-α,β-unsaturated Amides From Tertiary Amines, Olefins And CO Via Pd/Cu-catalyzed Aerobic Oxidative N-dealkylation

A novel Pd/Cu-catalyzed chemoselective aerobic oxidative N-dealkylation/carbonylation reaction has been developed for the efficient and straightforward construction of synthetically useful and bioactive (E)-α,β-unsaturated amide derivatives.