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Metal-free, One-pot Conversion Of Proline Derivatives Into 2-aryl-3-iodo Pyrrolidines By A Sequential Scission–iodination–arylation Process

Venkateswara Rao Batchu, Iván Romero-Estudillo, Alicia Boto, Javier Miguélez

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A sequential radical decarboxylation–oxidation–iodination–arylation process allows the metal-free, direct conversion of proline derivatives into 2-aryl-3-iodopyrrolidines, which are valuable precursors of a variety of heterocycles.