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Protein Nanoparticles For Therapeutic Protein Delivery.

L. Herrera Estrada, J. Champion
Published 2015 · Medicine, Biology

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Therapeutic proteins can face substantial challenges to their activity, requiring protein modification or use of a delivery vehicle. Nanoparticles can significantly enhance delivery of encapsulated cargo, but traditional small molecule carriers have some limitations in their use for protein delivery. Nanoparticles made from protein have been proposed as alternative carriers and have benefits specific to therapeutic protein delivery. This review describes protein nanoparticles made by self-assembly, including protein cages, protein polymers, and charged or amphipathic peptides, and by desolvation. It presents particle fabrication and delivery characterization for a variety of therapeutic and model proteins, as well as comparison of the features of different protein nanoparticles.
This paper references
10.1038/nrd2399
Protein therapeutics: a summary and pharmacological classification
B. Leader (2008)
10.1016/J.IJPHARM.2007.06.028
Human serum albumin (HSA) nanoparticles: reproducibility of preparation process and kinetics of enzymatic degradation.
K. Langer (2008)
10.1016/j.biomaterials.2009.05.060
Pharmacokinetics and bone formation by BMP-2 entrapped in polyethylenimine-coated albumin nanoparticles.
S. Zhang (2009)
10.1016/J.YMTHE.2005.06.474
Cell death induced by the herpes simplex virus-1 thymidine kinase delivered by human immunodeficiency virus-1-based virus-like particles.
Silvia Peretti (2005)
10.1163/156856298X00316
Elastic protein-based polymers in soft tissue augmentation and generation.
D. Urry (1998)
10.1021/nn302183h
Osmolyte-mediated encapsulation of proteins inside MS2 viral capsids.
J. Glasgow (2012)
10.1021/nn403085w
Biomimetic protein nanoparticles facilitate enhanced dendritic cell activation and cross-presentation.
Nicholas M. Molino (2013)
10.1038/nbt874
Fabrication of novel biomaterials through molecular self-assembly
S. Zhang (2003)
10.1371/journal.pone.0018758
Novel CCL21-Vault Nanocapsule Intratumoral Delivery Inhibits Lung Cancer Growth
U. Kar (2011)
10.1016/j.tips.2013.08.005
Building better drugs: developing and regulating engineered therapeutic proteins.
C. Kimchi-Sarfaty (2013)
10.1021/bm200983k
Colorful virus-like particles: fluorescent protein packaging by the Qβ capsid.
Jin-Kyu Rhee (2011)
10.1016/j.ijpharm.2012.04.040
Immunogenicity of protein aggregates--concerns and realities.
W. Wang (2012)
10.1016/J.COCIS.2007.07.010
Self-assembly and aggregation of proteins
E. Linden (2007)
10.1021/BM700888H
Effect of polymer amphiphilicity on loading of a therapeutic enzyme into protective filamentous and spherical polymer nanocarriers.
Eric A Simone (2007)
10.1016/j.addr.2009.07.014
Removal of B cell epitopes as a practical approach for reducing the immunogenicity of foreign protein-based therapeutics.
Satoshi Nagata (2009)
10.1007/978-1-60761-533-0_7
Lentivirus-based virus-like particles as a new protein delivery tool.
C. Muratori (2010)
10.1016/j.biomaterials.2013.11.001
Enzyme delivery using the 30Kc19 protein and human serum albumin nanoparticles.
Hong Jai Lee (2014)
10.7774/cevr.2014.3.2.227
Lumazine synthase protein cage nanoparticles as antigen delivery nanoplatforms for dendritic cell-based vaccine development
Jae-Sun Ra (2014)
10.1002/jps.22054
Delivery of therapeutic proteins.
D. Pisal (2010)
10.1016/J.BMC.2005.05.037
Protein oligomerization: how and why.
M. H. Ali (2005)
10.1038/nnano.2007.223
Immunological properties of engineered nanomaterials
M. Dobrovolskaia (2007)
10.1016/j.peptides.2009.10.002
Recent developments in liposomes, microparticles and nanoparticles for protein and peptide drug delivery
M. L. Tan (2010)
10.1038/nbt1201-1173
A peptide carrier for the delivery of biologically active proteins into mammalian cells
M. Morris (2001)
10.2174/1874357901206010270
Virus-Like Particles Harboring CCL19, IL-2 and HPV16 E7 Elicit Protective T Cell Responses in HLA-A2 Transgenic Mice
V. Juárez (2012)
10.1021/nn204166z
Concentrated dispersions of equilibrium protein nanoclusters that reversibly dissociate into active monomers.
Keith P. Johnston (2012)
10.1039/b804822n
Carbon nanotubes: biomaterial applications.
N. Saito (2009)
10.1021/nn900002m
Impact of nanotechnology on drug delivery.
O. Farokhzad (2009)
10.1073/PNAS.0500929102
Engineering of vault nanocapsules with enzymatic and fluorescent properties.
V. Kickhoefer (2005)
10.1016/j.biomaterials.2012.08.033
Non-amyloidogenic peptide tags for the regulatable self-assembling of protein-only nanoparticles.
U. Unzueta (2012)
10.1021/nn403184u
Designed nanocage displaying ligand-specific Peptide bunches for high affinity and biological activity.
J. O. Jeon (2013)
10.1039/C3RA45944F
Rational design of self-assembled proteins and peptides for nano- and micro-sized architectures
Kazunori Matsuurua (2014)
10.1016/J.NANO.2006.07.009
Adaptations of nanoscale viruses and other protein cages for medical applications.
L. A. Lee (2006)
10.1016/j.vaccine.2012.10.083
Virus-like particles as a highly efficient vaccine platform: Diversity of targets and production systems and advances in clinical development
N. Kushnir (2012)
10.1021/jp8062977
Effects of Hofmeister anions on the phase transition temperature of elastin-like polypeptides.
Y. Cho (2008)
10.1016/j.jconrel.2008.05.015
A peptide-based carrier for intracellular delivery of proteins into malignant glial cells in vitro.
C. Wu (2008)
10.1371/journal.pone.0005409
A Vault Nanoparticle Vaccine Induces Protective Mucosal Immunity
C. Champion (2009)
10.1016/j.biomaterials.2012.03.055
Developing an antibody-binding protein cage as a molecular recognition drug modular nanoplatform.
H. Kang (2012)
10.1016/j.bbamem.2010.02.027
PEP and CADY-mediated delivery of fluorescent peptides and proteins into living cells.
Laetitia Kurzawa (2010)
10.1016/j.ijpharm.2014.07.016
Intracellular targeting of CD44+ cells with self-assembling, protein only nanoparticles.
Mireia Pesarrodona (2014)
10.1165/RCMB.2002-0090OC
Alveolar wall apoptosis causes lung destruction and emphysematous changes.
K. Aoshiba (2003)
10.1016/j.copbio.2013.12.007
Caged protein nanoparticles for drug delivery.
Nicholas M. Molino (2014)
10.1039/c0cs00227e
Tailoring nanocarriers for intracellular protein delivery.
Z. Gu (2011)
10.1016/S0378-5173(99)00370-1
Desolvation process and surface characterisation of protein nanoparticles.
C. Weber (2000)
Highly efficient delivery of p16 antitumor peptide into aggressive leukemia/lymphoma cells using a novel transporter system.
E. Kondo (2004)
10.1021/nn901414q
Self-assembly of peptides into spherical nanoparticles for delivery of hydrophilic moieties to the cytosol.
L. Collins (2010)
10.1016/j.jconrel.2009.11.003
Thermoresponsive self-assembled elastin-based nanoparticles for delivery of BMPs.
Paulo C. Bessa (2010)
10.3390/ijms12085406
Self-Assembly in the Ferritin Nano-Cage Protein Superfamily
Y. Zhang (2011)
10.1002/adma.201200051
Multifunctional materials through modular protein engineering.
Rebecca L DiMarco (2012)
10.1021/bm300590x
Engineered mutations change the structure and stability of a virus-like particle.
Jason D. Fiedler (2012)
10.1016/j.jconrel.2008.05.010
Albumin as a drug carrier: design of prodrugs, drug conjugates and nanoparticles.
F. Kratz (2008)
10.1016/S0378-5173(03)00134-0
Optimization of the preparation process for human serum albumin (HSA) nanoparticles.
K. Langer (2003)
10.1021/JA00011A057
Temperature of polypeptide inverse temperature transition depends on mean residue hydrophobicity
D. W. Urry (1991)
10.1021/nn4055732
In vivo architectonic stability of fully de novo designed protein-only nanoparticles.
María Virtudes Céspedes (2014)
10.1002/anie.201005243
RNA-directed packaging of enzymes within virus-like particles.
Jason D. Fiedler (2010)
10.1016/J.RADPHYSCHEM.2013.05.057
Radio-synthesized protein-based nanoparticles for biomedical purposes
Gustavo H.C. Varca (2014)
10.1016/j.jconrel.2011.07.031
Albumin-based nanoparticles as potential controlled release drug delivery systems.
Ahmed O Elzoghby (2012)
10.1002/cbic.201100469
Cell Targeting with Hybrid Qβ Virus‐Like Particles Displaying Epidermal Growth Factor
J. Pokorski (2011)
10.1016/j.biomaterials.2011.10.053
Recombinant spider silk particles for controlled delivery of protein drugs.
M. Hofer (2012)
10.1038/nnano.2007.299
A virus-based single-enzyme nanoreactor.
Marta Comellas-Aragonès (2007)
10.1021/nl5002313
Controlled Apoptosis by a Thermally Toggled Nanoscale Amplifier of Cellular Uptake
Sarah R MacEwan (2014)
10.1039/C3PY00537B
A quantitative recipe for engineering protein polymer nanoparticles.
S. M. Janib (2014)
10.1016/j.jconrel.2014.08.015
Stimuli-responsive nanomaterials for therapeutic protein delivery.
Y. Lu (2014)
10.1186/1475-2859-11-1
Laboratory evolution of copper tolerant yeast strains
G. M. Adamo (2012)
10.1038/nri2868
Vaccine delivery: a matter of size, geometry, kinetics and molecular patterns
M. Bachmann (2010)
10.1016/j.bbamem.2008.01.029
Gramicidin A-based peptide vector for intracellular protein delivery.
Tatiana B Stoilova (2008)
10.1007/s11095-008-9692-2
Preparation of BMP-2 Containing Bovine Serum Albumin (BSA) Nanoparticles Stabilized by Polymer Coating
G. Wang (2008)
10.1016/j.ijpharm.2009.12.052
Silk fibroin nanoparticles for cellular uptake and control release.
J. Kundu (2010)
10.1038/nature13404
Accurate design of co-assembling multi-component protein nanomaterials
N. King (2014)
10.1073/pnas.1101874108
Protein delivery using engineered virus-like particles
S. J. Kaczmarczyk (2011)
10.1002/jps.23974
Protein nanoparticles for intracellular delivery of therapeutic enzymes.
L. H. Estrada (2014)
10.2174/1389203043486856
Physical mechanisms and biological significance of supramolecular protein self-assembly.
A. Kentsis (2004)
10.1016/j.copbio.2012.05.004
Vault particles: a new generation of delivery nanodevices.
A. Casañas (2012)
10.1016/j.tibtech.2013.09.002
Virus-like particle-based human vaccines: quality assessment based on structural and functional properties.
Qinjian Zhao (2013)
10.1002/marc.200900934
Intracellular Protein Delivery Systems Formed by Noncovalent Bonding Interactions between Amphipathic Peptide Carriers and Protein Cargos.
S. L. Lo (2010)
10.1002/anie.201302331
Two-step protein self-assembly in the extracellular matrix.
W. M. Park (2013)
10.1021/bc500339k
Engineered M13 bacteriophage nanocarriers for intracellular delivery of exogenous proteins to human prostate cancer cells.
Sandra M. DePorter (2014)
10.1016/j.jconrel.2012.04.036
Protein-based nanocarriers as promising drug and gene delivery systems.
Ahmed O Elzoghby (2012)
10.1016/j.vaccine.2010.03.079
Incorporation of CD40 ligand into SHIV virus-like particles (VLP) enhances SHIV-VLP-induced dendritic cell activation and boosts immune responses against HIV.
R. Zhang (2010)
10.1021/nn8008504
Vault nanoparticles containing an adenovirus-derived membrane lytic protein facilitate toxin and gene transfer.
Cheng-Yu Lai (2009)
10.1021/nn300545z
Nanoreactors by programmed enzyme encapsulation inside the capsid of the bacteriophage P22.
Dustin P Patterson (2012)
10.1016/j.bbagen.2009.12.005
The ferritin superfamily: Supramolecular templates for materials synthesis.
M. Uchida (2010)
10.1021/BM034215N
Quantification of the effects of chain length and concentration on the thermal behavior of elastin-like polypeptides.
D. E. Meyer (2004)
10.1016/j.nano.2013.11.003
Ferritin protein cage nanoparticles as versatile antigen delivery nanoplatforms for dendritic cell (DC)-based vaccine development.
Jae-A Han (2014)
10.1007/s10529-008-9834-y
Formulations for delivery of therapeutic proteins
S. Stolnik (2008)
10.1002/smll.201200066
Epidermal growth factor-ferritin H-chain protein nanoparticles for tumor active targeting.
X. Li (2012)
10.1016/J.COCIS.2013.06.002
Inorganic nanomaterials as delivery systems for proteins, peptides, DNA, and siRNA
M. Malmsten (2013)
10.1007/s12033-012-9598-4
Construction and Characterization of Virus-Like Particles: A Review
Andris Zeltiņš (2012)
10.1016/j.ejmech.2015.01.014
Peptide therapeutics: targeting the undruggable space.
N. Tsomaia (2015)
10.1016/j.jconrel.2014.06.028
Applications of elastin-like polypeptides in drug delivery.
Sarah R MacEwan (2014)
10.1023/A:1015929109894
Stability of Protein Pharmaceuticals
M. Manning (2004)
10.1152/AJPLUNG.00134.2004
PKA delivery to the distal lung air spaces increases alveolar liquid clearance after isoproterenol-induced alveolar epithelial PKA desensitization.
M. B. Maron (2005)
10.1007/978-3-540-69379-6_4
A library of protein cage architectures as nanomaterials.
M. Flenniken (2009)
10.1016/J.BIOMATERIALS.2004.07.047
Preparation and characterisation of antibody modified gelatin nanoparticles as drug carrier system for uptake in lymphocytes.
S. Balthasar (2005)
10.1016/j.nano.2013.08.005
Nanoclusters self-assembled from conformation-stabilized influenza M2e as broadly cross-protective influenza vaccines.
Li Wang (2014)
10.1002/smll.200801602
Protein-based nanomedicine platforms for drug delivery.
A. Maham (2009)
10.1158/1535-7163.MCT-07-2010
Potent synergy of dual antitumor peptides for growth suppression of human glioblastoma cell lines
E. Kondo (2008)
10.1016/j.jconrel.2014.04.028
Protein polymer nanoparticles engineered as chaperones protect against apoptosis in human retinal pigment epithelial cells.
W. Wang (2014)
10.1002/btpr.12
Polyethylenimine‐coated albumin nanoparticles for BMP‐2 delivery
S. Zhang (2008)
10.1039/c2ib20119d
Vault nanoparticles engineered with the protein transduction domain, TAT48, enhances cellular uptake.
J. Yang (2013)
10.1016/j.ddtec.2009.01.002
Intracellular delivery of protein and peptide therapeutics.
V. Torchilin (2008)
10.1016/J.CHEMBIOL.2005.11.007
Melanoma and lymphocyte cell-specific targeting incorporated into a heat shock protein cage architecture.
M. Flenniken (2006)
10.1126/science.1199081
Directed Evolution of a Protein Container
Bigna Wörsdörfer (2011)
10.1073/pnas.1009881108
Self-assembling elastin-like peptides growth factor chimeric nanoparticles for the treatment of chronic wounds
Piyush Koria (2010)
10.1021/nn800638x
Targeting vault nanoparticles to specific cell surface receptors.
V. Kickhoefer (2009)



This paper is referenced by
10.1002/wnan.1625
Emerging methods in therapeutics using multifunctional nanoparticles.
Nahal Habibi (2020)
10.1039/c6bm00500d
Effects of ovalbumin protein nanoparticle vaccine size and coating on dendritic cell processing.
Timothy Z. Chang (2017)
10.19080/ARGH.2018.09.555752
Hepatitis E Nanoparticle: A Capsid-Based Platform for Non-Invasive Vaccine Delivery and Imaging-Guided Cancer Treatment
R. Holland Cheng (2018)
10.1002/smll.201802618
Programed Assembly of Nucleoprotein Nanoparticles Using DNA and Zinc Fingers for Targeted Protein Delivery.
Yiseul Ryu (2018)
10.1201/9781315368863-2
Biopolymers in Regenerative Medicine: Overview, Current Advances and Future Trends
J. Ruso (2016)
10.1016/j.jconrel.2016.11.034
Bio‐nano interface: The impact of biological environment on nanomaterials and their delivery properties
Kaimin Cai (2017)
10.2147/IJN.S124938
The role of surface charge in the desolvation process of gelatin: implications in nanoparticle synthesis and modulation of drug release
Saad M Ahsan (2017)
10.1039/C6RA23036A
Functional characterizations of interactive recombinant PTEN–silica nanoparticles for potential biomedical applications
N. Arora (2016)
10.1371/journal.pone.0162848
Specific Internalisation of Gold Nanoparticles into Engineered Porous Protein Cages via Affinity Binding
David Paramelle (2016)
10.1016/J.MSEC.2019.109813
Effect of structure in ionised albumin based nanoparticle: Characterisation, Emodin interaction, and in vitro cytotoxicity.
M. Siri (2019)
10.1007/978-3-662-54357-3_11
Nanoparticles and Their Applications
S. Moeinzadeh (2017)
10.1016/j.carbpol.2018.12.083
The role of intermolecular interactions on the encapsulation of human insulin into the chitosan and cholesterol-grafted chitosan polymers.
Safoura Salar (2019)
10.3390/molecules25092193
Therapeutic Nanoparticles and Their Targeted Delivery Applications
Abuzer Alp Yetisgin (2020)
10.1016/J.ELECOM.2018.04.010
Electrochemical behavior of ferritin at the polarized water|1,2-dichloroethane interface
Hiroki Sakae (2018)
10.1016/j.jconrel.2017.08.014
Ferritin nanocage with intrinsically disordered proteins and affibody: A platform for tumor targeting with extended pharmacokinetics
Na Kyeong Lee (2017)
10.1101/631788
Effect of structure in ionized albumin – based nanoparticle: Characterisation, Emodin interaction, and in vitro cytotoxicity
Macarena Siri (2019)
10.1016/j.jconrel.2017.03.019
Nanocapsules of therapeutic proteins with enhanced stability and long blood circulation for hyperuricemia management
X. Zhang (2017)
10.1007/s10856-019-6294-y
Nanoscale cationic micelles of amphiphilic copolymers based on star-shaped PLGA and PEI cross-linked PEG for protein delivery application
Jun Wang (2019)
10.1039/C7MH01071K
Tumor-specific disintegratable nanohybrids containing ultrasmall inorganic nanoparticles: from design and improved properties to cancer applications
Y. Wang (2018)
10.1002/adma.201902791
Rational Design of Nanocarriers for Intracellular Protein Delivery.
Xiaofei Qin (2019)
10.1002/macp.202000003
Delivering Proapoptotic Peptide by HSP Nanocage for Cancer Therapy
Dongmei Wang (2020)
10.1039/c8bm01219a
Harnessing the layer-by-layer assembly technique to design biomaterials vaccines for immune modulation in translational applications.
Tan Tang (2019)
10.1039/c7bm00425g
Overcoming T. gondii infection and intracellular protein nanocapsules as biomaterials for ultrasonically controlled drug release.
M. Aw (2017)
10.1039/C5TB01647A
Self-assembled hybrid supraparticles that proteolytically degrade tumor necrosis factor-α.
W. M. Park (2016)
10.1021/acsnano.8b02381
Understanding the Interplay between Self-Assembling Peptides and Solution Ions for Tunable Protein Nanoparticle Formation.
Bhuvana Kamath Shanbhag (2018)
10.1038/s41598-018-34853-2
Enhancing Humoral Responses Against HIV Envelope Trimers via Nanoparticle Delivery with Stabilized Synthetic Liposomes
Talar Tokatlian (2018)
10.2174/2210681208666180125143953
Nanotechnology: Nanomedicine, Nanotoxicity and Future Challenges
V. Kumar (2018)
10.1021/acs.bioconjchem.6b00735
Protein Nanoparticle Formation Using a Circularly Permuted α-Helix-Rich Trimeric Protein.
Norifumi Kawakami (2017)
10.1021/acsami.7b03747
Multifunctional and Redox-Responsive Self-Assembled Magnetic Nanovectors for Protein Delivery and Dual-Modal Imaging.
H. Y. Yang (2017)
10.1016/j.biomaterials.2018.07.009
Designed trimer-mimetic TNF superfamily ligands on self-assembling nanocages.
Minwoo Kih (2018)
10.1016/j.jconrel.2016.11.032
Biodegradable Magnetic Silica@Iron Oxide Nanovectors with Ultra‐Large Mesopores for High Protein Loading, Magnetothermal Release, and Delivery
Haneen Omar (2017)
10.1039/C7TB02999C
Self-assembly of collagen-based biomaterials: preparation, characterizations and biomedical applications.
Shichen Zhu (2018)
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