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Copper(II)-catalyzed Oxidative N-nitrosation Of Secondary And Tertiary Amines With Nitromethane Under An Oxygen Atmosphere.

Norio Sakai, M. Sasaki, Yohei Ogiwara
Published 2015 · Chemistry, Medicine

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The combination of a catalytic amount of Cu(OTf)2 and less than a stoichiometric amount of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) under an O2 atmosphere effectively promoted the N-nitrosation of both secondary aromatic/aliphatic amines and tertiary aromatic amines with nitromethane (CH3NO2) leading to the preparation of N-nitrosamine derivatives.
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