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Chemical Synthesis Of The Outer Core Oligosaccharide Of Escherichia Coli R3 And Immunological Evaluation

Wenjing Shang, Zhongying Xiao, Zaikuan Yu, Na Wei, Guohui Zhao, Qing Zhang, Mohui Wei, Xuan Wang, Peng George Wang, Tiehai Li

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An all α-linked Escherichia coli R3 outer core pentasaccharide was first synthesized. Its corresponding glycoconjugate can elicit specific anti-pentasaccharide antibodies with in vitro bactericidal activity.