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Enantioselective Total Synthesis And Structural Reassignment Of (+)-alsmaphorazine E Via A Traceless Chirality Transfer Strategy.

K. Yu, B. Gao, Zhaobo Liu, H. Ding
Published 2016 · Chemistry, Medicine

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The first enantioselective total synthesis of (+)-alsmaphorazine E has been achieved through a traceless chirality transfer strategy, which also enabled structural reassignment of the natural product. Key features of this efficient approach entail a catalytic intramolecular oxidative cyclization, a diastereoselective oxidative cyclic aminal formation and a radical cyclization/transannular aza-Michael addition cascade.
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