Online citations, reference lists, and bibliographies.
← Back to Search

Evaluation Of The Toxicity Of Iron-ion Irradiation In Murine Bone Marrow Dendritic Cells Via Increasing The Expression Of Indoleamine 2,3-dioxygenase 1.

Yi Xie, Junfang Yan, J. Ma, H. Li, Yan-cheng Ye, Yan-Shan Zhang, H. Zhang
Published 2017 · Chemistry, Medicine, Biology

Save to my Library
Download PDF
Analyze on Scholarcy
High linear energy transfer radiation is known to deposit higher energy in tissues and cause greater toxicity compared to low-LET irradiation. Local immunosuppression is frequently observed after irradiation (IR). Dendritic cells (DCs) play important roles in the initiation and maintenance of the immune response. The dysfunction of DCs contributes to tumor evasion and growth. However, molecular mechanisms underlying the establishment of immune tolerance induced by heavy ion IR through this DC population are poorly understood. Therefore, here we report our findings on the dysfunction of bone marrow-derived dendritic cells (BMDCs) induced by 1 Gy iron ion radiation and promotions of expressions of JNK1/2/3, indoleamine 2,3-dioxygenase 1 (IDO1), p-ERK1/2 and p38/MAPK; and decrease of IDO2, MHC class II, CD40, CD80 expressions and IFN-γ and TNF-α secretion after total-body IR in mice. JNK+IDO1+ BMDCs showed up-expression of p-ERK1/2 and p-p38/MAPK, reduced expression of MHC class II and CD80, and were not able to effectively stimulate allogeneic spleen T cells. The inhibition of IDO1 expressions could partly restore the function of BMDCs. In all, our study shows that elevated JNK and IDO1 expression induced by Fe ion IR could result in dysfunction of BMDCs via p-p38/MAPK and p-ERK1/2 signal pathway, and it may represent a new mechanism in radiation-induced immune tolerance.
This paper references
IFN-γ Inhibits Presentation of a Tumor/Self Peptide by CD8α− Dendritic Cells Via Potentiation of the CD8α+ Subset1
U. Grohmann (2000)
Proteins synthesized by inducer T cells: evidence for a mitogenic peptide shared by inducer molecules that stimulate different cell types
M. Fresno (1982)
Modulation of dendritic cell maturation and function with mono‐ and bifunctional small interfering RNAs targeting indoleamine 2,3‐dioxygenase
Gro F. Flatekval (2009)
56Fe irradiation-induced cognitive deficits through oxidative stress in mice.
J. Yan (2016)
Inhibition of Allogeneic T Cell Proliferation by Indoleamine 2,3-Dioxygenase–expressing Dendritic Cells
P. Terness (2002)
Cellular signalling in programmed cell death (apoptosis).
D. McConkey (1990)
Anergic T cells are defective in both jun NH2-terminal kinase and mitogen-activated protein kinase signaling pathways
D. R. DeSilva (1996)
Tetherin Promotes the Innate and Adaptive Cell–Mediated Immune Response against Retrovirus Infection In Vivo
S. Li (2014)
Mitochondria and MAPK cascades modulate endosulfan-induced germline apoptosis in Caenorhabditis elegans.
Jingjing Wang (2017)
Emergency medicine in space.
L. Stewart (2007)
Tryptophan catabolism and T-cell tolerance: immunosuppression by starvation?
A. Mellor (1999)
HZE Particle and Neutron Dosages from Cosmic Rays on the Lunar Surface
K. Hayatsu (2009)
Critical stoichiometric ratio of CD4+ CD25+ FoxP3+ regulatory T cells and CD4+ CD25− responder T cells influence immunosuppression in patients with B‐cell acute lymphoblastic leukaemia
K. Bhattacharya (2014)
Towards a cellular definition of CD8+ T-cell memory: the role of CD4+ T-cell help in CD8+ T-cell responses.
B. Rocha (2004)
Phenotype and functions of spleen dendritic cells in RICK-knockout mice.
G. Yao (2010)
B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy
V. Kuchroo (1995)
Characterization of regulatory dendritic cells differentiated from the bone marrow of UV‐irradiated mice
Royce L. X. Ng (2013)
Cloning and expression of a cDNA encoding mouse indoleamine 2,3-dioxygenase.
Habara-Ohkubo Akemi (1991)
Galactic cosmic rays and cell-hit frequencies outside the magnetosphere.
S. Curtis (1989)
The IDO1 selective inhibitor epacadostat enhances dendritic cell immunogenicity and lytic ability of tumor antigen-specific T cells
C. Jochems (2016)
Pathological roles of MAPK signaling pathways in human diseases.
E. Kim (2010)
Indoleamine 2,3-dioxygenase-expressing mature human monocyte-derived dendritic cells expand potent autologous regulatory T cells.
D. Chung (2009)
Cancer despite immunosurveillance: immunoselection and immunosubversion
L. Zitvogel (2006)
Molecular mechanism and cellular function of MHCII ubiquitination
Jaehak Oh (2015)
An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow.
M. B. Lutz (1999)
CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes
E. Janssen (2003)
Overexpression of Indoleamine 2,3-Dioxygenase in Human Endometrial Carcinoma Cells Induces Rapid Tumor Growth in a Mouse Xenograft Model
Norio Yoshida (2008)
Molecules in focus: indoleamine 2,3-dioxygenase.
N. King (2007)
The Role of Regulatory CD4 T Cells in Maintaining Tolerance in a Mouse Model of Autoimmune Hepatitis
Ira An Haack (2015)
Differential regulation of indoleamine 2,3‐dioxygenase by lipopolysaccharide and interferon gamma in murine bone marrow derived dendritic cells
I. Jung (2007)
A murine model for bone loss from therapeutic and space-relevant sources of radiation.
S. A. Hamilton (2006)
Extracellular Signal-Regulated Kinase and p38 Subgroups of Mitogen-Activated Protein Kinases Regulate Inducible Nitric Oxide Synthase and Tumor Necrosis Factor-α Gene Expression in Endotoxin-Stimulated Primary Glial Cultures
N. Bhat (1998)
A Defect in Tryptophan Catabolism Impairs Tolerance in Nonobese Diabetic Mice
U. Grohmann (2003)
Flow cytometric analysis of activation markers on stimulated T cells and their correlation with cell proliferation.
A. Caruso (1997)
Cross‐regulation of CD86 by CD80 differentially regulates T helper responses from Mycobacterium tuberculosis secretory antigen‐activated dendritic cell subsets
M. Y. Balkhi (2004)
Species and Cell Types Difference in Tryptophan Metabolism
Yuki Murakami (2013)
Adrenomedullin, a neuropeptide with immunoregulatory properties induces semi‐mature tolerogenic dendritic cells
S. Rullé (2012)
T-cell priming by type-1 and type-2 polarized dendritic cells: the concept of a third signal.
P. Kalinski (1999)
NF-κB, p38 MAPK, ERK1/2, mTOR, STAT3 and increased glycolysis regulate stability of paricalcitol/dexamethasone-generated tolerogenic dendritic cells in the inflammatory environment
Klára Dáňová (2015)
Integrin signalling and function in immune cells
Y. Zhang (2012)
Tolerance, DCs and tryptophan: much ado about IDO.
U. Grohmann (2003)
Nucleofection Is an Efficient Nonviral Transfection Technique for Human Bone Marrow–Derived Mesenchymal Stem Cells
M. Aluigi (2006)
Dendritic Cells and Tumor Microenvironment: A Dangerous Liaison
Ingo Fricke (2006)

This paper is referenced by
Semantic Scholar Logo Some data provided by SemanticScholar