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Self-assembled Adhesive Biomaterials Formed By A Genetically Designed Fusion Protein.
Pulakesh Aich, Jaeyeon An, Byeongseon Yang, Y. Ko, Junghyun Kim, J. Murray, H. J. Cha, J. H. Roh, K. Park, K. Kim
Published 2018 · Chemistry, Medicine
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Here we report a recombinant protein (MS) obtained by genetic fusion of a mussel foot protein (Mfp3) motif into a silk spidroin (MaSp1). The MS not only self-assembled into a supramolecular fibre, as does the parent MaSp1, but also showed enhanced adhesiveness resulting from the DOPA-containing Mfp3 portion. The successful incorporation of the wet adhesiveness of Mfp3 into the well-structured assembly of MaSp1 may provide a new insight for the genetic design of underwater adhesive recombinant proteins by utilizing the structural features of a spidroin protein.
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