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Engineering Graphene Oxide With Ultrasmall SPIONs And Smart Drug Release For Cancer Theranostics

Yu Luo, Yan Tang, Tianzhi Liu, Qian Chen, Xiaohan Zhou, Ning Wang, Ming Ma, Yingsheng Cheng, Hangrong Chen

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An intelligent nanoplatform is constructed by conjugating cis-aconitic anhydride-modified doxorubicin to weakly crystallized, ultrasmall SPION loaded graphene oxide (GO) nanosheets. More importantly, the composites present ultrasensitive breakage hydrolysis induced by pH alteration, achieving on-demand, gradual drug release in the tumor microenvironment.