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Engineering Of A Bioluminescent Probe For Imaging Nitroxyl In Live Cells And Mice.

J. Li, Qianqian Wang, H. Liu, X. Yin, Xiao-xiao Hu, L. Yuan, X. Zhang
Published 2019 · Chemistry, Medicine

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A bioluminescent probe, BP-HNO, which exhibits a turn-on response to nitroxyl with high sensitivity and selectivity, is reported for the first time in this work. BP-HNO is free from the interference of biological autofluorescence to afford a high signal-to-noise ratio for bioimaging, and was successfully applied to imaging nitroxyl in live cells and mice.
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