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Allocolchicinoids Bearing A Michael Acceptor Fragment For Possible Irreversible Binding Of Tubulin

Ekaterina S. Sazanova, Iuliia A. Gracheva, Diane Allegro, Pascale Barbier, Sébastien Combes, Elena V. Svirshchevskaya, Alexey Yu Fedorov

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We describe an attempt to apply the concept of covalent binding towards the highly active allocolchicinoids selected on the basis of SAR analysis of previously synthesized molecules.