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Differential Induction Of Brain, Lung And Liver Nitric Oxide Synthase By Endotoxin In The Rat

R G Knowles, M Merrett, M Salter, S Moncada

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Nitric oxide (NO) synthase in rat brain was found to be constitutive and Ca2(+)-dependent. The enzyme in rat lung or liver (predominantly in parenchymal cells) was not constitutive, but was induced by endotoxin treatment and was Ca2(+)-independent. The NO synthases in rat brain and liver or lung are therefore distinct both in their properties and in their regulation.