Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

Furosemide Inhibits Regenerative Cortical Spreading Depression In Anaesthetized Cats

S. J. Read, M. I. Smith, C. Benham, A. Hunter, A. A. Parsons
Published 1997 · Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
Ionic perturbations occur during cortical spreading depression (SD), a phenomenon implicated in migraine pathophysiology. We studied the effect of 0.2,2 and 20 mg kg-1 iv (n=4) furosemide on cortical direct current (d.c.) potential, cerebrovascular laser Doppler flux (rCBFLDF), artery diameter and NO concentration in the parietal cortex of the anaesthetized cat during repetitive SD. In vehicle treated animals (n=4), SD activity was sustained for 50 1.8 min. However, duration of SD activity was significantly reduced when compared to vehicle to 39 6.6 (n=4), 3.1 8.3 (n = 4) and 27.3 11.3 min (n=4), at 0.2, 2 and 20 mg kg-1 iv furosemide respectively. It is hypothesized that the mechanism of inhibition of SD d.c. activity by furosemide may be through alterations in cortica ion buffering capacity or inhibition of cell swelling in neurones or glia. These mechanisms may represent potential novel drug targets in future migraine therapy.
This paper references
10.1046/j.1471-4159.1995.65010096.x
Uptake of l‐Glutamate into Rat Brain Synaptic Vesicles: Effect of Inhibitors that Bind Specifically to the Glutamate Transporter
S. Roseth (1995)
10.1097/00003246-198810000-00008
Mediators of brain edema and secondary brain damage
A. Baethmann (1988)
10.1016/S0304-3940(97)00604-6
The dynamics of nitric oxide release measured directly and in real time following repeated waves of cortical spreading depression in the anaesthetised cat
S. J. Read (1997)
10.1007/BF00967284
Ethacrynic acid and furosemide alter Cl, K, and Na distribution between blood, choroid plexus, CSF, and brain
C. Johanson (2004)
10.1016/0166-2236(87)90115-9
Cortical spreading depression as a putative migraine mechanism
M. Lauritzen (1987)
10.1046/J.1468-2982.1997.1703159.X
Enhanced Nitric Oxide Release During Cortical Spreading Depression Following Infusion of Glyceryl Trinitrate in the Anaesthetized Cat
S. J. Read (1997)
10.1016/0006-8993(95)00778-O
Hypotonic exposure enhances synaptic transmission and triggers spreading depression in rat hippocampal tissue slices
S. R. Chebabo (1995)
Selective antagonist for the cerebellar granule cell-specific gamma-aminobutyric acid type A receptor.
E. Korpi (1995)
10.1126/science.270.5233.99
Dissociation of Synchronization and Excitability in Furosemide Blockade of Epileptiform Activity
D. Hochman (1995)
10.1038/jcbfm.1984.42
Intense Furosemide-Sensitive Potassium Accumulation in Astrocytes in the Presence of Pathologically High Extracellular Potassium Levels
W. Walz (1984)
10.1016/0306-4522(87)90029-7
Effect of mannitol treatment on brain neurotransmitter markers in kainic acid-induced epilepsy
H. Baran (1987)
10.1111/j.1749-6632.1991.tb15622.x
Glial Ion Transport and Volume Control
O. Kempski (1991)
10.1016/0006-8993(94)91234-3
Involvement of calcitonin gene-related peptide (CGRP) and nitric oxide (NO) in the pial artery dilatation elicited by cortical spreading depression
M. Wahl (1994)
10.1111/j.1476-5381.1996.tb15369.x
Angiotensin II‐elicited signal transduction via AT1 receptors in endothelial cells
M. Pueyo (1996)
10.1016/0006-8993(92)91470-Y
Nitric oxide synthesis couples cerebral blood flow and metabolism
P. Goadsby (1992)



This paper is referenced by
10.1007/S11916-996-0016-0
Cortical spreading depression: Its role in migraine pathogenesis and possible therapeutic intervention strategies
A. A. Parsons (2004)
10.1016/S0006-8993(00)02400-8
Sumatriptan modifies cortical free radical release during cortical spreading depression: A novel antimigraine action for sumatriptan?
S. J. Read (2000)
10.1046/j.1526-4610.2003.00556.x
Abstracts and Citations
Kenneth. (1998)
10.1590/S1807-59322009000400019
Migraine with Persistent Visual Aura: Response to Furosemide
R. F. de Almeida (2009)
10.1016/S0306-4522(00)00025-7
Effects of chloride transport inhibition and chloride substitution on neuron function and on hypoxic spreading-depression-like depolarization in rat hippocampal slices
M. Müller (2000)
10.1046/j.1468-2982.2000.00022.x
SB-220453, A Potential Novel Antimigraine Agent, Inhibits Nitric Oxide Release Following Induction of Cortical Spreading Depression in the Anaesthetized Cat
S. J. Read (2000)
10.1017/S1464793106007081
Physiological studies of cortical spreading depression.
J. Smith (2006)
10.1586/ern.09.103
CSD, BBB and MMP-9 elevations: animal experiments versus clinical phenomena in migraine
V. Gupta (2009)
10.1212/WNL.55.5.732
Treatment of a prolonged migrainous aura with intravenous furosemide
T. Rozen (2000)
10.1111/j.1526-4610.2012.02103.x
Migraine With Persistent Visual Aura
R. Evans (2012)
10.1212/WNL.55.5.733
Echolalia–palilalia as the sole manifestation of nonconvulsive status epilepticus
E. Linetsky (2000)
10.1046/j.1469-7580.2001.19850537.x
Investigation of feline brain anatomy for the detection of cortical spreading depression with magnetic resonance imaging
J. Smith (2001)
Cessation of Hemiplegic Migraine Auras With Greater Occipital Nerve Blockade
G. Merlino (2007)
10.1111/j.1526-4610.2007.00828.x
Cessation of Hemiplegic Migraine Auras With Greater Occipital Nerve Blockade
T. Rozen (2007)
10.1111/j.1469-185X.2006.tb00214.x
Physiological studies of cortical spreading depression
Justin M. Smith (2006)
10.1016/j.expneurol.2008.03.026
The impact of anesthetics and hyperoxia on cortical spreading depression
Chiho Kudo (2008)
10.1177/0271678X18771440
Systematic review of the pharmacological agents that have been tested against spreading depolarizations
Anna L. Klass (2018)
10.1152/physrev.00027.2014
Spreading Depression, Spreading Depolarizations, and the Cerebral Vasculature.
C. Ayata (2015)
10.1097/00019052-199806000-00006
Recent advances in mechanisms of spreading depression.
A. A. Parsons (1998)
10.1111/J.1476-4431.2007.00267.X
The pharmacologic spectrum of furosemide
L. Abbott (2008)
The pharmacologic spectrumof furosemide
L. Abbott (2008)
10.1152/jn.00348.2018
Time-resolved quantification of the dynamic extracellular space in the brain: study of cortical spreading depression.
Hui-Hui Zhao (2019)
10.1093/CERCOR/11.3.249
Anoxic depolarization mediates acute damage independent of glutamate in neocortical brain slices.
Cathryn R. Jarvis (2001)
10.1212/CON.0000000000000191
Emergency Department and Inpatient Management of Status Migrainosus and Intractable Headache
T. Rozen (2015)
10.1111/j.1526-4610.2007.00638.x
Chronic Daily Headache in Hereditary Hemochromatosis Treated by Venesection
C. Gaul (2007)
10.1007/s42451-020-00255-w
Prolongierte Migräneaura – ein einfacher Notfall?
E. Frank (2020)
Semantic Scholar Logo Some data provided by SemanticScholar