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Nasal Lymphoid Tissue (NALT) As A Mucosal Immune Inductive Site

H. Wu, H. Nguyen, M. Russell
Published 1997 · Biology, Medicine

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Intranasal (i.n.) immunization is a very effective route for inducing mucosal immunity, but the cellular mechanism responsible for regulating and disseminating these responses is not fully understood. The authors studied the role of nasal lymphoid tissue (NALT) as a mucosal inductive site by using highly purified NALT cells obtained by a new method of mechanical isolation. The NALT cells, like Peyer's patch (PP) cells, were smaller in size and less granular than lymphocytes from salivary glands (SG) and small intestinal lamina propria (LP). The NALT cells isolated from i.n. immunized mice contained antigen‐specific antibody‐secreting cells (ASC) predominantly of immunoglobulin (Ig)A isotype, similar to those also recovered from salivary glands in a time course study. However, the higher proportion of smaller sized spots formed by NALT cells in ELISPOT assays suggested that these cells were less differentiated precursors of those found in salivary glands. This was supported by the fact that after i.n. immunization, IgA ASC appeared in NALT, as well as in mucosal effector sites SG and LP, but none or very few in another mucosal inductive site, PP. In contrast, after intragastric (i.g.) immunization, IgA ASC were detected in PP, along with the SG and LP, but none or very few in NALT. Furthermore, after i.n. immunization, lymphocytes from NALT but not PP proliferated in response to the specific antigen in culture. These findings imply that NALT served as an inductive site for IgA antibody responses at mucosal effector sites.
This paper references
10.1046/j.1365-2567.1996.d01-690.x
Induction of antibody‐secreting cells and T‐helper and memory cells in murine nasal lymphoid tissue
H. Wu (1996)
10.1086/513980
Intranasal immunization of mice with PspA (pneumococcal surface protein A) can prevent intranasal carriage, pulmonary infection, and sepsis with Streptococcus pneumoniae.
H. Wu (1997)
10.1128/IAI.59.11.4061-4070.1991
Distribution, persistence, and recall of serum and salivary antibody responses to peroral immunization with protein antigen I/II of Streptococcus mutans coupled to the cholera toxin B subunit.
M. Russell (1991)
10.1007/BF02786362
Nasal lymphoid tissue, intranasal immunization, and compartmentalization of the common mucosal immune system
H. Wu (1997)
10.1111/j.1348-0421.1995.tb02212.x
Sheep Red Blood Cell Instillation at Palatine Tonsil Effectively Induces Specific IgA Class Antibody in Saliva in Rabbits
T. Fukuizumi (1995)
10.1093/INFDIS/168.3.622
Mucosal immunity and protection after intranasal immunization with recombinant adenovirus expressing herpes simplex virus glycoprotein B.
W. S. Gallichan (1993)
10.1128/JVI.65.2.657-663.1991
Effectiveness of enteric immunization in the development of secretory immunoglobulin A response and the outcome of infection with respiratory syncytial virus.
T. Kanesaki (1991)
10.1016/S0264-410X(97)00168-0
Induction of mucosal and systemic immune responses by intranasal immunization using recombinant cholera toxin B subunit as an adjuvant.
H. Wu (1998)
10.1128/IAI.63.4.1195-1200.1995
Adjuvanticity and protective immunity elicited by Bordetella pertussis antigens encapsulated in poly(DL-lactide-co-glycolide) microspheres.
R. Shahin (1995)
10.1128/IAI.61.5.1964-1971.1993
Protective salivary immunoglobulin A responses against Streptococcus mutans infection after intranasal immunization with S. mutans antigen I/II coupled to the B subunit of cholera toxin.
J. Katz (1993)
10.1016/0264-410X(89)90240-5
Enhancement of protective antibody responses by cholera toxin B subunit inoculated intranasally with influenza vaccine.
S. Tamura (1989)
10.1016/0167-5699(92)90158-4
The role of nasopharyngeal lymphoid tissue.
C. Kuper (1992)
10.1128/IAI.61.1.314-322.1993
Induction of mucosal immunity by intranasal application of a streptococcal surface protein antigen with the cholera toxin B subunit.
H. Wu (1993)
10.1128/IAI.65.1.227-235.1997
Development of antibody-secreting cells and antigen-specific T cells in cervical lymph nodes after intranasal immunization.
H. Wu (1997)
10.1016/0264-410X(90)90053-O
Comparison of intranasal inoculation of influenza HA vaccine combined with cholera toxin B subunit with oral or parenteral vaccination.
Y. Hirabayashi (1990)
Synthetic peptide vaccine against mucosal colonization by group A streptococci. I. Protection against a heterologous M serotype with shared C repeat region epitopes.
D. Beßen (1990)
Immunogenicity and protective effect against oral colonization by Streptococcus mutans of synthetic peptides of a streptococcal surface protein antigen.
I. Takahashi (1991)



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10.1371/journal.pone.0001501
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R. Bright (2008)
10.1128/IAI.68.10.5509-5516.2000
Adjuvant Activity of Monophosphoryl Lipid A for Nasal and Oral Immunization with Soluble or Liposome-Associated Antigen
N. Childers (2000)
10.1093/femspd/ftv068
Bordetella pertussis transmission.
Elizabeth A Trainor (2015)
10.3390/scipharm87040027
Recent Approaches for Solid Dose Vaccine Delivery
Nishat Jahan (2019)
10.1128/IAI.01395-07
Differential Uptake and Processing of a Haemophilus influenzae P5-Derived Immunogen by Chinchilla Dendritic Cells
L. Novotny (2007)
Importance of L-selectin in the induction of immune responses in the upper respiratory tract
Keri L. Csencsits (2001)
10.1128/JVI.77.6.3615-3623.2003
Enhancement of Mucosal Immunization with Virus-Like Particles of Simian Immunodeficiency Virus
S. Kang (2003)
10.1007/82_2020_208
Chronic Inflammation in Mucosal Tissues: Barrier Integrity, Inducible Lymphoid Tissues, and Immune Surveillance.
Rajrupa Chakraborty (2020)
10.3109/02713680903395281
Nasal-Associated Lymphoid Tissue Is Not an Absolute Requirement for the Induction of Rat Tear IgA Antibody Responses
R. Gill (2010)
10.1111/j.1398-9995.2011.02782.x
Implications of nasopharynx‐associated lymphoid tissue (NALT) in the development of allergic responses in an allergic rhinitis mouse model
D-Y. Kim (2012)
10.1016/j.antiviral.2008.06.013
A novel recombinant bacterial vaccine strain expressing dual viral antigens induces multiple immune responses to the Gag and gp120 proteins of HIV-1 in immunized mice
Y. Feng (2008)
10.4049/jimmunol.174.3.1317
Characterization of a B220+ Lymphoid Cell Subpopulation with Immune Modulatory Functions in Nasal-Associated Lymphoid Tissues
F. Rharbaoui (2005)
10.1002/eji.201646700
Nasopharyngeal colonization with Streptococcus pneumoniae triggers dendritic cell dependent antibody responses against invasive disease in mice
Anne Dommaschk (2017)
10.3390/antib5040020
Systemic and Mucosal Antibody Responses to Soluble and Nanoparticle-Conjugated Antigens Administered Intranasally
Savannah E. Howe (2016)
10.1016/J.TIV.2006.03.009
Respiratory immunotoxicity: an in vitro assessment.
E. Roggen (2006)
Streptococcus pyogenes Survival of Streptococcus pneumoniae and Biofilm Formation Enhances Fomite
Laura Reid Marks (2014)
10.1007/978-1-4939-9199-0
Streptococcus pneumoniae
Federico Iovino (2019)
PropriaTissue , but Not in the Diffuse Lamina LymphoidNasopharynx-and Gut-Associated IgA Class Switch Occurs in the Organized
Takashi Shikina (2004)
10.1034/J.1399-302X.2003.00074.X
Remote glucosyltransferase-microparticle vaccine delivery induces protective immunity in the oral cavity.
D. Smith (2003)
10.1111/j.1365-3083.2009.02358.x
Striking Activation of NALT and Nasal Passages Lymphocytes Induced by Intranasal Immunization with Cry1Ac protoxin
M. Rodriguez-Monroy (2010)
10.1111/j.1365-2567.2007.02671.x
Differential expression of adhesion molecules and chemokines between nasal and small intestinal mucosae: implications for T‐ and sIgA+ B‐lymphocyte recruitment
D. Bourges (2007)
Naoto Inflammatory Responses in the Nasal Tract Antigen Trafficking and Induce Enterotoxin-Based Mucosal Adjuvants Alter
Jerry R. Mcghee (2005)
10.1016/S1461-5347(00)00281-9
Intranasal vaccines: forthcoming challenges.
Partidos (2000)
10.1016/J.VETMIC.2005.11.062
The recombinant rabbit hemorrhagic disease virus VP60 protein obtained from Pichia pastoris induces a strong humoral and cell-mediated immune response following intranasal immunization in mice.
Omar Farnós (2006)
10.1016/S0002-9440(10)64841-9
Human nasopharyngeal-associated lymphoreticular tissues. Functional analysis of subepithelial and intraepithelial B and T cells from adenoids and tonsils.
P. Boyaka (2000)
Functions in Nasal-Associated Lymphoid Subpopulation with Immune Modulatory Characterization of a B220+ Lymphoid Cell
Jan Buer (2013)
10.1201/B20045-17
Polyester Particles for Drug Delivery to the Skin: Local and Systemic Applications
M. Kumar (2017)
10.3389/fimmu.2013.00245
Treg Inducing Adjuvants for Therapeutic Vaccination Against Chronic Inflammatory Diseases
C. Keijzer (2013)
10.1128/IAI.68.1.205-213.2000
In Vivo Characterization of the Murine Intranasal Model for Assessing the Immunogenicity of Attenuated Salmonella enterica Serovar Typhi Strains as Live Mucosal Vaccines and as Live Vectors
T. E. Pickett (2000)
10.1128/IAI.67.8.3937-3946.1999
Limited Local and Systemic Antibody Responses toNeisseria gonorrhoeae during Uncomplicated Genital Infections
S. R. Hedges (1999)
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