Online citations, reference lists, and bibliographies.
← Back to Search

A Possible Role Of The Carotid Body In The Pathogenesis Of Cluster Headache

L. Kudrow
Published 1983 · Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
An hypothesis regarding the possible role of the carotid body in the pathogenesis of cluster headache is presented. It states: 1. The pathways concerned with cyclic cluster periods may begin centrally involving specific areas in the hypothalamus. The major influence of this physiological change is proposed to be an inhibition of the sympathetic and disinhibition of parasympathetic supplies to the carotid body. The result, whether due to increased vasomotor tonus or interruption of intrinsic sympathetic stimulation, is suggested to cause diminished peripheral chemoreceptor activity. 2. The pathway concerned with onset of spontaneous or induced attacks begins, as proposed, with oxygen desaturation-which, upon reaching threshold levels may induce a hyperactive chemoreceptor response, and stimulate through afferent pathways the nuclei of the 7th and 10th cranial nerves and respiratory centers, via the nucleus solitarius. 3. The consequence of this excitation may involve the third suggested pathway resulting in stimulation of peripheral secretory and other receptors innervated by the cranial nerves.
This paper references
and bradycardia
D Russell (1976)
The structural basis of an inner-vatory system of brain vessels
J. Cervos-Navarro (1977)
10.3995/jstroke.2.280
Role of noradrenergic system in cerebral arterial spasm after subarachnoid hemorrhage.
F. Gotoh (1977)
10.1093/sleep/1.2.199
Membrane potential of spinal motoneurons during natural sleep in cats.
L. Glenn (1978)
10.1111/j.1600-0404.1970.tb05617.x
HEART RATE, BLOOD PRESSURE, AND ELECTROCARDIOGRAPHIC CHANGES DURING PROVOKED ATTACKS OF CLUSTER HEADACHE
K. Ekbom (1970)
10.1177/028418517001000302
Carotid Angiography in Cluster Headache
K. Ekbom (1970)
Dissociation des deux sensibilités réflexogènes de la bifurcation carotidienne: sensibilité chimique et sensibilité à la pression
C Heymans (1933)
Environmental stress : individual human adaptations
L. Folinsbee (1978)
Membrane potential of spinal
L Glenn
10.1152/JN.1972.35.4.405
Mitochondrial respiratory chain of carotid body and chemoreceptor response to changes in oxygen tension.
E. Mills (1972)
10.3171/JNS.1947.4.2.0105
Resection of the greater superficial petrosal nerve in the treatment of unilateral headache.
W. J. Gardner (1947)
Cluster Headache: Mechanisms and Management
L. Kudrow (1981)
10.1097/00000441-195805000-00025
Functional neuro-anatomy
A. R. Buchanan (1958)
10.1016/B978-0-12-261350-0.50031-4
SLEEP HYPOXEMIA AT ALTITUDE: ITS RELATIONSHIP TO ACUTE MOUNTAIN SICKNESS AND VENTILATORY RESPONSIVENESS TO HYPOXIA AND HYPERCAPNIA
A. Powles (1978)
10.1001/ARCHNEUR.1968.00480050057005
Nitrolglycerin as a provocative agent in cluster headache.
K. Ekbom (1968)
: a rare cause of bradycardia
K Ekbom (1969)
10.1152/AJPLEGACY.1968.214.5.969
Reflex chemoceptive regulation of arterial pressure during natural sleep in the cat.
M. Guazzi (1968)
10.1111/j.1526-4610.1976.hed1601011.x
CLUSTER HEADACHE AND BRADYCARDIA
G. Bruyn (1976)
10.1111/j.1476-5381.1975.tb06922.x
FACTORS AFFECTING THE CEREBROVASCULAR RESPONSE TO NORADRENALINE IN THE DOG
I. James (1975)
10.1007/978-1-4612-5668-7
The Paraganglionic Chemoreceptor System
F. Zak (1982)
10.1002/0471743984.vse5091
Neuralgia
(1851)
Carotid sinus nerve efferents: properties and physiological significance.
S. Majcherczyk (1980)
Cluster headache: mechanisms & management
L. Kudrow (1980)
10.1111/j.1600-0404.1970.tb05618.x
PATTERNS OF CLUSTER HEADACHE WITH A NOTE ON THE RELATIONS TO ANGINA PECTORIS AND PEPTIC ULCER
K. Ekbom (1970)
10.1111/j.1526-4610.1982.hed2201035.x
Systemic Arterial Pressure and Heart Rate Changes During Migraine and Cluster Headaches: Preliminary Study
F. Cirignotta (1982)
10.1016/0013-4694(75)90188-1
Sleep physiology at high altitude.
M. Reite (1975)
10.1111/j.1526-4610.1970.hed0904187.x
PHYSIOLOGIC MECHANISMS AND TREATMENT OF HISTAMINIC OR PETROSAL NEURALGIA
A. Stowell (1970)
10.1007/BF00218147
Structure of cells and nerve endings in abdominal vagal paraganglia of the rat
M. Morgan (2004)
10.3171/JNS.1968.28.1.0054
The role of the nervus intermedius in facial neuralgia. Report of four cases with observations on the pathways for taste, lacrimation, and pain in the face.
E. Sachs (1968)
The Paraganglionic Chemoreceptor System: Physiology, Pathology and Clinical Medicine
F. Zak (1982)
The structural basis of an inner - vatory system of brain vessels . In : Ovarian C , Edvinsson L eds Neurogenic control of brain circulation
J Cervos-Navarro (1977)
Response of cluster
L Kudrow
Localization by the horseradish peroxidase technique of medullary neurons projecting efferent fibers to the carotid sinus nerve of the cat
W CDeGroat (1978)
The endocrine hypothalamus: recent anatomical studies.
S. Joseph (1978)
The structural basis of an innervatory system of brain vessels
J. Cervós-Navarro (1977)
10.1080/22953337.1979.11718676
Endocrine rhythms.
D. Désir (1979)
measured by the 133 Xe inhalation method
L Jacobson (1978)
10.5694/j.1326-5377.1971.tb50532.x
ACUTE MOUNTAIN SICKNESS: AN HISTORICAL REVIEW, WITH SOME EXPERIENCES FROM THE PERUVIAN ANDES
J. Sutton (1971)
Recurrent brief headache in cluster pattern.
E. C. Kunkle (1952)
10.1113/jphysiol.1961.sp006806
The effect of sympathetic stimulation on carotid nerve activity
C. Eyzaguirre (1961)
10.1111/j.1526-4610.1975.hed1501051.x
STUDIES IN NOCTURNAL MIGRAINE
J. Dexter (1974)
10.1161/01.RES.31.2.267
Sympathetic Control of Cerebral Blood Flow in Dogs
L. D'alecy (1972)
10.1111/j.1526-4610.1981.hed2101001.x
Response of Cluster Headache Attacks to Oxygen Inhalation
L. Kudrow (1981)
10.1111/j.1600-0404.1976.tb04367.x
CEREBRAL BLOOD FLOW CHANGES IN CLUSTER HEADACHE
J. Norris (1976)
Observations on the fine structure and histochemistry of the carotid body in the cat and rabbit.
J. Lever (1959)
Effects of efferent nerves upon total blood flow, local flow, tissue PO2 and chemoreceptor activity of the cat carotid body
R GO'Regan (1981)
10.1113/jphysiol.1971.sp009617
Participation of the anterior hypothalamus in the baroreceptor reflex
S. Hilton (1971)
10.1113/jphysiol.1967.sp008219
Factors affecting the cat carotid chemoreceptor and cervical sympathetic activity with special reference to passive hind‐limb movements
T. Biscoe (1967)
10.1113/jphysiol.1969.sp008810
Respiratory responses to electrical stimulation of the cervical sympathetic nerves in decerebrate, unanaesthetized cats
E. Mills (1969)
10.1111/j.1526-4610.1978.hed1803122.x
Regional Cerebral Hemodynamics During Migraine and Cluster Headaches Measured by the 133Xe Inhalation Method
F. Sakai (1978)
10.1212/WNL.33.12.1638-A
Mechanism and Management of Headache,ED. 4
R. Daroff (1983)
Carotid body blood flow and oxygen usage in the cat.
M. Purves (1969)
attacks to oxygen inhalation
E Kunkle (1981)
Recurrent brief headache in cluster pattern.
Kunkle Ec (1952)
Carotid body blood flow and oxygen usage in the cat.
Purves Mj (1969)
10.1046/j.1468-2982.1982.0202061.x
Cluster Headache: Heart Rate and Blood Pressure Changes During Spontaneous Attacks
D. Russell (1982)
10.1056/NEJM196901232800402
Acute mountain sickness.
I. Singh (1969)
10.1113/jphysiol.1974.sp010484
The role of the carotid body chemoreceptors and carotid sinus baroreceptors in the control of cerebral blood vessels
J. Ponte (1974)
Endocrine rhythms. In: Martini L Series ed Comprehensive endocrinology
D T.Krieger (1979)
A new syndrome of vascular headache: results of treatment with histamine; a preliminary report
B THorton (1939)
10.7326/0003-4819-42-1-214_1
Clinical aspects of the autonomic nervous system
L. A. Gillilan (1955)
10.1113/jphysiol.1975.sp010794
Effects of dopamine on carotid chemo‐ and baroreceptors in vitro.
P. Zapata (1975)
The regulation of heart rate during sleep.
W. Baust (1969)
10.1007/BF01098781
The innervation of glomus cells, ganglion cells and blood vessels in the rat carotid body: A quantitative ultrastructural analysis
D. McDonald (1975)
Chemoreceptor synapses in the carotid body.
C. Eyzaguirre (1972)
10.1111/j.1526-4610.1969.hed0804159.x
CLUSTER HEADACHE: A RARE CAUSE OF BRADYCARDIA
L. B. Jacobson (1969)
10.1016/B978-0-08-023768-8.50595-8
588 – POSSIBILITY OF A FUNCTIONAL RELATIONSHIP BETWEEN ADRENERGIC AND CHOLINERGIC INNERVATION IN CEREBRAL ARTERIES OF THE GOAT
G. Martin (1978)
10.1111/j.1526-4610.1979.hed1906309.x
The Nature of Cluster Headache
J. Medina (1979)
Functional neuro-anatomy, 3rd ed
A R.Buchanan (1957)
10.1113/jphysiol.1954.sp005143
Observations on the volume of blood flow and oxygen utilization of the carotid body in the cat
M. Daly (1954)
10.1113/jphysiol.1970.sp009172
The role of the cervical sympathetic nerve in the regulation of oxygen consumption of the carotid body of the cat
M. Purves (1970)
10.7326/0003-4819-73-6-1055_1
Mechanism and management of headache
J. Lance (1973)



This paper is referenced by
10.1007/S11916-009-0027-8
Cluster headache and obstructive sleep apnea: Are they related disorders?
S. Graff-Radford (2009)
10.1007/978-3-319-01875-1_11
Headaches, Migraine, and Cluster Headache
Ghabi A. Kaspo (2014)
10.3233/BMR-1996-6204
Orofacial pain - an overview.
S. Graff-Radford (1996)
10.1111/j.1526-4610.2007.00839.x
Trigeminal Autonomic Cephalalgias: Current and Future Treatments
A. Cohen (2007)
10.1111/j.1468-2982.1998.1810675.x
Thermal Sensitivity in Unilateral Headaches
N. Becser (1998)
10.1111/j.1468-2982.2004.00897.x
Investigation Into Sleep Disturbance of Patients Suffering from Cluster Headache
M. Nobre (2005)
10.1177/03331024850050S3115
The Occurrence of Headache in Patients with Atherosclerotic Lesions of the Carotid Body
M. de Marinis (1985)
10.1016/S0025-7125(16)30434-5
Diagnosis and treatment of cluster headache.
L. Kudrow (1991)
10.1177/03331024850050S3144
Onset of Nocturnal Attacks of Chronic Cluster Headache in Relation to Sleep Stages
W. Poellmann (1985)
10.1016/S1567-4231(09)70053-X
Chapter 28 Headaches and sleep disorders
M. Silber (2005)
10.1111/j.1600-0404.1986.tb03296.x
Onset of nocturnal attacks of chronic cluster headache in relation to sleep stages
V. Pfaffenrath (1986)
10.1111/j.1526-4610.1995.hed3502079.x
Rapid and Sustained Relief of Migraine Attacks With Intranasal Lidocaine: Preliminary Findings
L. Kudrow (1995)
10.1111/j.1526-4610.1993.hed3309483.x
The Role of Chemoreceptor Activity and Oxyhemoglobin Desaturation in Cluster Headache
L. Kudrow (1993)
10.1007/S11916-003-0026-0
Cluster headaches and sleep disorders
J. Weintraub (2003)
10.1007/PL00014998
The role of cavernous sinus in cluster and other headaches
G. Relja (1999)
10.1111/j.1526-4610.1991.hed3103146.x
The Effect of Hyperventilation in Cluster Headache Patients
F. Antonaci (1991)
10.1111/j.1526-4610.1995.hed3506344.x
Respiratory Studies in SUNCT Syndrome
P. Kruszewski (1995)
10.1111/j.1526-4610.1994.hed3402083.x
Cluster Headache: The Peripheral Chemosensitivity as Indicated by the Single‐Breath CO2 Test
J. Shen (1994)
10.1111/J.1743-5013.2005.20415.X
Primary Headache Disorders and Circadian Biology: A Clinical, Imaging, and Therapy Perspective
Anna S. Cohen (2005)
10.1046/j.1468-2982.2003.00561.x
Cluster Headache Associated with Sleep Apnoea
M. Nobre (2003)
10.1111/j.1526-4610.2004.446010.x
Obstructive Sleep Apnea and Cluster Headache
S. Graff-Radford (2004)
10.1007/s101940200014
Cold room air inhalation to abort cluster headaches: an exploratory study
Martha Sue McLeod (2002)
10.1111/j.1526-4610.1990.hed3010656.x
Cluster Headache: The Effect of Low Oxygen Saturation
J. M. Zhao (1990)
10.1016/B978-0-7216-0334-6.50048-0
chapter 44 – Cluster Headache
S. Diamond (2007)
Topical review: cluster headache and sleep-related breathing disorders.
Steven D. Bender (2011)
10.1155/1996/654071
Pathophysiology of Headaches with a Prominent Vascular Component
J. Pareja (1996)
10.1111/J.1526-4610.1991.HED3102123A.X
Cluster Headache and the Carotid Body
L. Kudrow (1991)
10.1111/j.1526-4610.1993.hed3309476.x
Cluster Headache: The Ventilatory Response to Transient Hypoxia with Pure Nitrogen
J. Shen (1993)
10.1007/978-3-642-60819-3_24
Neurologische Indikationen von Lithium
A. Berghöfer (1997)
10.1111/j.1526-4610.1990.hed3008474.x
Association of Sustained Oxyhemoglobin Desaturation and Onset of Cluster Headache Attacks
L. Kudrow (1990)
10.1111/head.12730
A Review of Cardiovascular Autonomic Control in Cluster Headache
M. Barloese (2016)
Semantic Scholar Logo Some data provided by SemanticScholar