Online citations, reference lists, and bibliographies.
← Back to Search

Opioid Control Of The Hypothalamus-Pituitary-Adrenal Axis Cyclically Fails In Menstrual Migraine

F. Facchinetti, E. Martignoni, L. Fioroni, G. Sances, A. Genazzani
Published 1990 · Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
To assess the biological correlates of the precipitation of migraine attacks in the perimenstrual period, plasma b-endorphin (b-EP) and cortisol responses to naloxone (8 mg iv) and corticotropin releasing hormone (100 μg iv) were evaluated in both the follicular phase and the premenstrual period in 7 patients suffering from menstrual migraine and in 7 healthy, asymptomatic control volunteers. In the controls, naloxone evoked a significant release of both b-EP (F = 5.86, p < 0.002) and cortisol (F = 4.43, p < 0.008), independently of the menstrual cycle phase (F = 0.31 and 1.04, for b-EP and cortisol, respectively). Menstrual migraine patients, on the other hand, showed a significant hormone response only in the follicular phase, not in the premenstrual period. Corticotropin releasing hormone significantly increased b-EP and cortisol in both the controls and the menstrual migraine patients, independently of the menstrual cycle phase. In both the naloxone and corticotropin releasing hormone testings, the basal b-EP levels measured in the premenstrual period were lower than those observed in the follicular phase (p < 0.02). These data demonstrate a cyclical, premenstrual dysfunction of the hypothalamic control exerted by opioids on the hypothalamus-pituitary-adrenal axis. Impairment of this fundamental adaptive mechanism (involved in stress responses and in pain control) could establish a causal relationship between menstrual-related migraine attacks and premenstrual opioid hyposensitivity.
This paper references
10.1177/03331024860060S413
13: Migraine: A Biobehavioral Disorder
K. Welch (1986)
10.1016/S0015-0282(16)49034-5
Neuropeptide levels in premenstrual syndrome.
C. J. Chuong (1985)
Practical evaluation of hormonal status
RW Rebar (1986)
Progressive impairment of CSF beta-EP levels in migraine sufferers.
A. Genazzani (1984)
10.1016/S0015-0282(16)59104-3
Premenstrual fall of plasma β-endorphin in patients with premenstrual syndrome *
F. Facchinetti (1987)
10.3758/BF03198725
Alteration of shock aversion thresholds during the menstrual cycle
W. H. Tedford (1977)
10.1055/S-2007-1021868
Endogenous Opiate Peptides and Premenstrual Syndrome
R. Reid (1987)
10.1016/S0166-2236(84)80009-0
Endogenous opioid peptides and the menstrual cycle
M. Ferin (1984)
Opioids in mental illness: theories, clinical observations, and treatment possibilities.
K. Verebey (1982)
Sympathergic/neuroendocrine reactivity as a marker of cyclic susceptibility to menstrual migraine
E Martignoni (1988)
10.1136/jnnp.48.4.328
Serum dopamine beta-hydroxylase activity in menstrual migraine.
A. Magos (1985)
10.1111/j.1365-2265.1982.tb01591.x
OPIATES CONTROL ACTH THROUGH A NORADRENERGIC MECHANISM
A. Grossman (1982)
10.1016/0306-4530(80)90026-8
Short-term hormonal effects of naloxone in man
J. Volavka (1980)
Migraine. A biobehavioral disorder.
K. Welch (1987)
10.1146/ANNUREV.NE.07.030184.001521
Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry.
A. Basbaum (1984)
Studies of the pain threshold in man
PM Procacci (1974)
Transient failure of central opioid tonus and premenstrual symptoms.
F. Facchinetti (1988)
10.1016/S0140-6736(83)91172-8
OESTRADIOL/PROGESTERONE IMBALANCE AND THE PREMENSTRUAL SYNDROME
F. Facchinetti (1983)
10.1016/0304-3959(88)90178-9
Neuroendocrine evaluation of central opiate activity in primary headache disorders
F. Facchinetti (1988)
10.1016/S0140-6736(78)92100-1
HORMONAL AND METABOLIC RESPONSES TO AN ENKEPHALIN ANALOGUE IN NORMAL MAN
W. Stubbs (1978)
10.1159/000124463
Different opioid mechanisms are involved in the modulation of ACTH and gonadotrophin release in man.
A. Grossman (1986)
10.1016/0306-4530(75)90006-2
Circulating hormones, EEG, and performance in psychological tests of women with and without oral contraceptives
W. Wuttke (1975)
10.1210/JCEM-59-3-412
The role of endogenous opiates in the mechanism of inhibited luteinizing hormone (LH) secretion in women with anorexia nervosa: the effect of naloxone on LH, follicle-stimulating hormone, prolactin, and beta-endorphin secretion.
B. Baranowska (1984)
10.1016/0196-9781(82)90098-5
The opiomelanotropinergic neuronal and endocrine systems
T. O'donohue (1982)
10.1016/0024-3205(88)90293-7
On the site of action of naloxone-stimulated cortisol secretion in gilts.
M. Estienne (1988)
10.1016/0306-4530(76)90011-1
Menstrual cycle status and adrenocortical reactivity to pyschological stress
Kathleen T. Marinari (1976)



This paper is referenced by
10.1046/j.1468-2982.1997.1705561.x
A Clinical Review of the Adaptive Role of Vasopressin in Migraine
V. Gupta (1997)
10.1159/000071706
Neuroendocrine Response to the Serotonin Agonist M-Chlorophenylpiperazine in Women with Menstrual Status migrainosus
R. Nappi (2003)
10.1111/j.1526-4610.2007.00817.x
Neuroactive Properties of Reproductive Steroids
A. Herzog (2007)
10.1046/j.1468-2982.1991.1102087.x
Exteroceptive Silent Period of Temporalis Muscle in Menstrual Headaches
J. Schoenen (1991)
10.1007/S11916-000-0006-6
Sex, gender, and pain: Women and men really are different
R. Fillingim (2000)
10.1046/j.1468-2982.1993.1306422.x
The Association of Menstrual Migraine with the Premenstrual Syndrome
F. Facchinetti (1993)
10.1007/s10194-012-0424-y
Migraine in women: the role of hormones and their impact on vascular diseases
S. Sacco (2012)
10.1016/0306-4530(90)90077-M
Neuroendocrine correlates of premenstrual syndrome: changes in the pulsatile pattern of plasma LH
F. Facchinetti (1990)
10.1155/1996/654071
Pathophysiology of Headaches with a Prominent Vascular Component
J. Pareja (1996)
10.1016/j.genm.2009.03.006
Ovarian hormones and pain response: a review of clinical and basic science studies.
V. Martin (2009)
10.1007/s10072-018-3333-2
Estrogen, migraine, and vascular risk
G. Allais (2018)
10.1097/00006842-199709000-00008
Ischemic but Not Thermal Pain Sensitivity Varies Across the Menstrual Cycle
R. Fillingim (1997)
10.1046/j.1468-2982.1996.1601011.x
“Menstrual” Migraine: Towards a Definition
E. MacGregor (1996)
10.1783/147118907779399684
Menstrual migraine: a clinical review
E. MacGregor (2007)
10.1016/j.psyneuen.2014.10.013
Sex differences in acute hormonal and subjective response to naltrexone: The impact of menstrual cycle phase
D. Roche (2015)
Neurovascular Pharmacology of Migraine: Epigenetics and Sex Hormones
S. Labruijere (2014)
10.1016/S1474-4422(02)00191-6
The hypothalamus in episodic brain disorders
S. Overeem (2002)
The Influence of Estrogen on Migraine
Jan Lewis Brandes (2016)
Menstrual migraine: the role of oestrogen.
A. Macgregor (2008)
10.1016/S0733-8619(05)70299-1
Menstruation, sex hormones, and migraine.
E. MacGregor (1997)
10.1046/J.1468-2982.1994.1406411.X
Menstrual Migraine is Not Pathogenetically Related to Premenstrual Syndrome
V. Gupta (1994)
10.1111/j.1526-4610.2006.00370.x
Ovarian Hormones and Migraine Headache: Understanding Mechanisms and Pathogenesis—Part 2
V. Martin (2006)
10.14260/JEMDS/188
A STUDY OF PAIN PERCEPTION DURING THE DIFFERENT PHASES OF MENSTRUAL CYCLE
Rolinda Rajkumari (2012)
10.1046/j.1468-2982.1994.1406413.x
The Premenstrual Syndrome Belongs in the Diagnostic Criteria for Menstrual Migraine
F. Facchinetti (1994)
10.1016/S0149-7634(00)00017-8
Sex-related hormonal influences on pain and analgesic responses
R. Fillingim (2000)
10.1016/j.neubiorev.2010.05.001
Ovarian hormones and propensity to drug relapse: A review
Amanda Hudson (2011)
10.1097/00006842-199409000-00006
Changes of opioid modulation of the hypothalamo‐pituitary‐adrenal axis in patients with severe premenstrual syndrome.
F. Facchinetti (1994)
10.1046/j.1468-2982.1995.1504297.x
Changes of Neuroendocrine Axes in Patients with Menstrual Migraine
L. Fioroni (1995)
10.1111/j.1526-4610.1990.hed3011751_a.x
Abstracts and Citations
S. Solomon (1990)
10.1097/01.PSY.0000021945.35402.0D
Changes in Nociceptive Flexion Reflex Threshold Across the Menstrual Cycle in Healthy Women
C. Tassorelli (2002)
10.1001/JAMA.295.15.1824
The influence of estrogen on migraine: a systematic review.
J. Brandes (2006)
10.1016/j.ejpn.2020.02.006
Manifestation of migraine in adolescents: Does it change in puberty?
Bettina Böttcher (2020)
See more
Semantic Scholar Logo Some data provided by SemanticScholar