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Cerebrospinal Fluid Neuropeptides And Monoaminergic Transmitters In Patients With Trigeminal Neuralgia

Matthias Strittmatter, Markus Grauer, E. Isenberg, G. Hamann, C. Fischer, K. Hoffmann, Franz Biaes, K. Schimrigk
Published 1997 · Medicine

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The pathogenesis of trigeminal neuralgia remains largely unknown. "Peripheral" as well as "central" causes have been suggested. To investigate the role of serotonergic, noradrenergic, dopaminergic, and peptidergic systems, we determined the concentrations of epinephrine, norepinephrine, and their breakdown product, vanillylmandelic acid, in the cerebrospinal fluid of 16 patients (55.3 ±± 8.3 years) with trigeminal neuralgia. As a marker for the dopaminergic system, we determined cerebrospinal fluid concentrations of dopamine and its metabolite, homovanillic acid. As a marker for the serotonergic system, we measured cerebrospinal fluid levels of the serotonin metabolite, 5‐hydroxyindoleacetic acid. In addition, levels of the neuropeptides, substance P and somatostatin, were determined.
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