Online citations, reference lists, and bibliographies.
Referencing for people who value simplicity, privacy, and speed.
Get Citationsy
← Back to Search

Regeneration And Functional Recovery In The Upper Extremity Of Rats After Various Types Of Nerve Injuries

E. Bontioti, M. Kanje, L. Dahlin
Published 2003 · Medicine

Save to my Library
Download PDF
Analyze on Scholarcy Visualize in Litmaps
Share
Reduce the time it takes to create your bibliography by a factor of 10 by using the world’s favourite reference manager
Time to take this seriously.
Get Citationsy
Abstract  The aim was to establish an accurate, reproducible, and simple method to evaluate functional recovery after different types of nerve injuries to the brachial plexus of rats. To that end, pawprints, measured as distance between the first and fourth and second and third digits, were used for evaluation of injuries including crush injury, transection/repair, or graft repair of the median, ulnar, and radial nerves. Immunocytochemistry of the C‐terminal flanking peptide of neuropeptide Y (CPON) and neurofilaments was used to investigate the cell body response and axonal outgrowth, respectively. Functional recovery was dependent on the severity as well as on the level of the lesion. Neither a single injury to the median nerve nor an injury to the ulnar nerve affected the pawprint, while an injury to both these nerves or a single injury to the radial nerve caused impairment of pawprints. There was a rapid recovery after crush injury to these nerves compared to previous reports of a similar injury to the sciatic nerve. The pattern of axonal outgrowth was related to the severity of the lesion. A conditioning lesion, i.e., an initial lesion of the same nerve preceding a test injury by a few days, of both motor/sensory fibers led to a quicker functional recovery. Surprisingly, conditioning of only sensory fibers had nearly the same effect. The cell body response was dependent on the level of the nerve lesion. The upper extremity of rats might be useful to evaluate the effects of new repair methods after nerve injuries using functional evaluation with pawprints as a simple and accurate method.
This paper references
10.1016/S0003-9993(97)90013-7
Exercise training improves functional recovery and motor nerve conduction velocity after sciatic nerve crush lesion in the rat.
N. V. van Meeteren (1997)
10.1016/S0165-0270(01)00378-8
Functional evaluation of peripheral nerve regeneration in the rat: walking track analysis
A. S. Varejão (2001)
10.1016/0031-9384(92)90301-H
Reaching behavior in the rat: Absence of forelimb peripheral input
M. Šaling (1992)
10.1016/0165-0270(94)00169-H
The grasping test: a simple behavioral method for objective quantitative assessment of peripheral nerve regeneration in the rat
J. Bertelli (1995)
10.1055/S-2007-1006472
Ankle stance angle: a functional index for the evaluation of sciatic nerve recovery after complete transection.
F. M. Lin (1996)
10.1016/S0165-0270(99)00174-0
Methods to evaluate functional nerve recovery in adult rats: walking track analysis, video analysis and the withdrawal reflex
J. Dijkstra (2000)
10.1016/S0306-4522(01)00148-8
Effect of peripheral nerve injury on dorsal root ganglion neurons in the C57 BL/6J mouse: marked changes both in cell numbers and neuropeptide expression
T. Shi (2001)
A comparison of assessments of functional recovery in the rat.
T. Hadlock (1999)
10.1016/0166-2236(94)90031-0
Messenger plasticity in primary sensory neurons following axotomy and its functional implications
T. Hökfelt (1994)
10.1053/JHSU.2000.4165
A 25-year perspective of peripheral nerve surgery: evolving neuroscientific concepts and clinical significance.
G. Lundborg (2000)
10.1016/0031-9384(95)00072-Q
Differential fore- and hindpaw force transmission in the walking rat
K. Clarke (1995)
10.1016/0006-8993(77)90193-7
Axonal regeneration in the rat sciatic nerve: Effect of a conditioning lesion and of dbcAMP
I. Mcquarrie (1977)
10.1097/00001756-200110290-00010
C-terminal flanking peptide of neuropeptide Y in DRG following nerve compression
A. Widerberg (2001)
10.1080/08990229970474
Estimation of the number and size of female adult rat C4, C5 and C6 dorsal root ganglia (DRG) neurons.
L. Mille-Hamard (1999)
10.1016/0165-0270(93)90068-3
Behavioral evaluating methods in the objective clinical assessment of motor function after experimental brachial plexus reconstruction in the rat
J. Bertelli (1993)
10.1055/S-2007-1000085
Rat walking tracks do not reflect maximal muscle force capacity.
M. S. Urbanchek (1999)
10.1006/exnr.1999.7210
Spatiotemporal Progress of Nerve Regeneration in a Tendon Autograft Used for Bridging a Peripheral Nerve Defect
J. Brandt (1999)
10.1007/BF00211769
Methodological aspects on immunohistochemistry in dermatology with special reference to neuronal markers
A. Ljungberg (2004)
10.3109/17453679308993673
Acute nerve compression at low pressures has a conditioning lesion effect on rat sciatic nerves.
L. Dahlin (1993)
10.1016/0165-0270(91)90048-5
The “staircase test”: a measure of independent forelimb reaching and grasping abilities in rats
C. P. Montoya (1991)
10.1016/0166-4328(86)90082-3
Quantitative measurement of interresponse times to assess forelimb motor function in rats
M. Gonzalez (1986)
10.1016/0006-8993(89)91497-2
Neuronal loss in lumbar dorsal root ganglia after proximal compared to distal sciatic nerve resection: a quantitative study in the rat
J. Ygge (1989)
10.1001/ARCHNEUR.1973.00490250071008
Axon outgrowth enhanced by a previous nerve injury.
I. Mcquarrie (1973)
10.1016/S0165-0270(00)00281-8
Video analysis of standing — an alternative footprint analysis to assess functional loss following injury to the rat sciatic nerve
M. Bervar (2000)
10.1016/0006-8993(90)90676-3
Effects of repetitive conditioning crush lesions on regeneration of the rat sciatic nerve
Jacob Sjo¨berg (1990)
10.1002/MICR.1920160207
The rat brachial plexus and its terminal branches: An experimental model for the study of peripheral nerve regeneration
J. Bertelli (1995)
Hindlimb muscle function in relation to speed and gait: in vivo patterns of strain and activation in a hip and knee extensor of the rat (Rattus norvegicus).
G. Gillis (2001)
10.1016/S0006-8993(01)03052-9
H reflex restitution and facilitation after different types of peripheral nerve injury and repair
A. Valero-Cabré (2001)
10.1002/(SICI)1097-4598(199701)20:1<29::AID-MUS4>3.0.CO;2-J
Inaccurate projection of rat soleus motoneurons: A comparison of nerve repair techniques
S. Bodine-Fowler (1997)
10.1016/0014-4886(82)90234-5
An index of the functional condition of rat sciatic nerve based on measurements made from walking tracks
L. D. Medinaceli (1982)
10.1097/00001756-200112040-00036
Experimental nerve compression and upregulation of CPON in DRG
M. Bergmark (2001)
10.1016/0006-8993(90)90812-P
The initial period of peripheral nerve regeneration and the importance of the local environment for the conditioning lesion effect
J. Sjöberg (1990)
10.1007/BF01944724
A new method of measuring functional recovery after crushing the peripheral nerves in unanesthetized and unrestrained rats
Kiyonao Hasegawa (2005)



This paper is referenced by
10.1177/1753193411426969
Neurophysiological and morphological responses to treatment with acetyl-L-carnitine in a sciatic nerve injury model: preliminary data
S. Karşidağ (2012)
WHAT TO EXPECT AND HOW TO DISCUSS ABOUT OUTCOMES AFTER NERVE SURGERY
Artur Soczka (2017)
10.1002/ana.25664
Restoration of Somatosensory Function by Pairing Vagus Nerve Stimulation with Tactile Rehabilitation
Michael J Darrow (2019)
10.1007/s00221-007-1174-y
Manual stimulation of forearm muscles does not improve recovery of motor function after injury to a mixed peripheral nerve
N. Sinis (2007)
10.1016/S0074-7742(09)87004-9
Chapter 4: Methods and protocols in peripheral nerve regeneration experimental research: part I-experimental models.
P. Tos (2009)
10.1080/02844310600574056
End-to-side nerve repair: Attachment of a distal, compared with a proximal and distal, nerve segment
E. Bontioti (2006)
10.1515/BC.2008.100
Bone marrow-derived mesenchymal stem cell transplantation does not improve quality of muscle reinnervation or recovery of motor function after facial nerve transection in rats
M. Grosheva (2008)
10.1007/s10103-011-0972-4
Functional and morphometric differences between the early and delayed use of phototherapy in crushed median nerves of rats
A. P. Santos (2011)
Brain plasticity and hand function
A. Björkman (2005)
10.1111/ejn.13089
Clinical and neurobiological advances in promoting regeneration of the ventral root avulsion lesion
R. Eggers (2016)
10.1155/2013/514610
Electroacupuncture and Acupuncture Promote the Rat's Transected Median Nerve Regeneration
C. Ho (2013)
10.1016/j.aanat.2011.02.014
Intrinsic and therapeutic factors determining the recovery of motor function after peripheral nerve transection.
E. Skouras (2011)
10.1111/j.1529-8027.2008.00162.x
Measurement of forelimb function by digital video motion analysis in rat nerve transection models
H. Wang (2008)
10.1016/j.hcl.2008.04.007
Nerve fiber transfer by end-to-side coaptation.
H. Millesi (2008)
10.1016/j.jneumeth.2008.10.001
Skilled forelimb reaching in Wistar rats: Evaluation by means of Montoya staircase test
A. Pagnussat (2009)
10.1007/s00221-019-05593-0
Quantitative assessment of cortical somatosensory digit representations after median and ulnar nerve injury in rats
D. Hulsey (2019)
10.1097/WNR.0b013e328302f4ec
Nerve compression induces activating transcription factor 3 in neurons and Schwann cells in diabetic rats
L. Dahlin (2008)
10.1177/145749690809700407
Techniques of Peripheral Nerve Repair
L. Dahlin (2008)
adhesion‐associated DNA methylation patterns of Schwann cells and identified candidate genes that may potentially regu‐ late Schwann cell adhesion in Wistar rats before and after PNI
Shanhuai Zuo (2020)
10.1016/S0074-7742(09)87007-4
Chapter 7: Methods and protocols in peripheral nerve regeneration experimental research: part IV-kinematic gait analysis to quantify peripheral nerve regeneration in the rat.
L. M. Costa (2009)
10.1007/s11064-019-02863-9
Functional Recovery Occurs Even After Partial Remyelination of Axon-Meshed Median and Ulnar Nerves in Mice
A. E. Speck (2019)
10.1016/S0074-7742(09)87012-8
Chapter 12: Mechanisms underlying the end-to-side nerve regeneration.
E. Bontioti (2009)
10.1016/B978-072160361-2.50021-1
Chapter 18 – Peripheral Nerve Injuries
Ginny Gibson (2007)
10.4172/2157-7013.1000156
Gene Therapy in Rodents Models of Traumatic Peripheral Nerve Injury
J. T. Oliveira (2014)
10.1002/mus.20971
Electrophysiologic findings and grip strength after nerve injuries in the rat forelimb
H. Wang (2008)
10.1007/978-3-642-18120-7_2
Attempts to Improve Axonal Pathfinding and Quality of Target Reinnervation
D. Angelov (2011)
10.1007/s00401-005-0005-0
Functional recovery improvement is related to aberrant reinnervation trimming. A comparative study using fresh or predegenerated nerve grafts
J. Bertelli (2005)
10.1002/ar.23058
The Rabbit Brachial Plexus as a Model for Nerve Repair Surgery—Histomorphometric Analysis
P. Reichert (2015)
10.1111/j.1085-9489.2003.03027.x
Nerve injury and repair – a challenge to the plastic brain
G. Lundborg (2003)
10.1007/s10571-018-0633-2
An In Vitro Model for Conditioning Lesion Effect
Elif Kaval Oğuz (2018)
10.1111/j.1085-9489.2005.10109.x
End‐to‐side nerve repair in the upper extremity of rat
E. Bontioti (2005)
10.1080/01616412.2015.1114742
Swimming does not alter nociception threshold in obese rats submitted to median nerve compression
Josinéia Gresele Coradini (2015)
See more
Semantic Scholar Logo Some data provided by SemanticScholar