Online citations, reference lists, and bibliographies.
← Back to Search

Computed Tomography-based Lung Nodule Volumetry--do Optimized Reconstructions Of Routine Protocols Achieve Similar Accuracy, Reproducibility And Interobserver Variability To That Of Special Volumetry Protocols?

H. Bolte, C. Riedel, N. Knoess, S. Freitag, B. Hoffmann, M. Heller, J. Biederer
Published 2007 · Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
PURPOSE The aim of this in vitro and ex vivo CT study was to investigate whether the use of a routine thorax protocol (RTP) with optimized reconstruction parameters can provide comparable accuracy, reproducibility and interobserver variability of volumetric analyses to that of a special volumetry protocol (SVP). MATERIALS AND METHODS To assess accuracy, 3 polyurethane (PU) spheres (35 HU; diameters: 4, 6 and 10 mm) were examined with a recommended SVP using a multislice CT (collimation 16 x 0.75 mm, pitch 1.25, 20 mAs, slice thickness 1 mm, increment 0.7 mm, medium kernel) and an optimized RTP (collimation 16 x 1.5 mm, pitch 1.25, 100 mAs, reconstructed slice thickness 2 mm, increment 0.4 mm, sharp kernel). For the assessment of intrascan and interscan reproducibility and interobserver variability, 20 artificial small pulmonary nodules were placed in a dedicated ex vivo chest phantom and examined with identical scan protocols. The artificial lesions consisted of a fat-wax-Lipiodol mixture. Phantoms and ex vivo lesions were examined afterwards using commercial volumetry software. To describe accuracy the relative deviations from the true volumes of the PU phantoms were calculated. For intrascan and interscan reproducibility and interobserver variability, the 95 % normal range (95 % NR) of relative deviations between two measurements was calculated. RESULTS For the SVP the achieved relative deviations for the 4, 6 and 10 mm PU phantoms were - 14.3 %, - 12.7 % and - 6.8 % and were 4.5 %, - 0.6 % and - 2.6 %, respectively, for the optimized RTP. SVP showed a 95 % NR of 0 - 1.5 % for intrascan and a 95 % NR of - 10.8 - 2.9 % for interscan reproducibility. The 95 % NR for interobserver variability was - 4.3 - 3.3 %. The optimized RTP achieved a 95 % NR of - 3.1 - 4.3 % for intrascan reproducibility and a 95 % NR of - 7.0 - 3.5 % for interscan reproducibility. The 95 % NR for interobserver variability was - 0.4 - 6.8 %. CONCLUSION For datasets achieved with an SVP and an optimized RTP, this experimental approach showed comparable accuracy, reproducibility, and interobserver variability to allow for sufficient volumetric analysis of pulmonary lesions.



This paper is referenced by
10.1016/J.IJROBP.2007.08.031
Respiratory-gated helical computed tomography of lung: reproducibility of small volumes in an ex vivo model.
J. Biederer (2007)
10.1007/s00330-010-1966-5
Semi-automated volumetric analysis of lymph node metastases during follow-up—initial results
M. Fabel (2010)
10.1007/s10278-008-9157-5
Variability of Semiautomated Lung Nodule Volumetry on Ultralow-Dose CT: Comparison with Nodule Volumetry on Standard-Dose CT
P. Hein (2008)
10.1007/s00117-008-1738-2
Automatisierte Verfahren zur Volumetrie von Metastasen
M. Fabel (2008)
10.1186/2047-783X-15-8-345
Liver volume measurement: reason of the difference between in vivo CT-volumetry and intraoperative ex vivo determination and how to cope it
S. Niehues (2010)
10.1055/s-2008-1027285
[Computer-aided detection of small pulmonary nodules in multidetector spiral computed tomography (MSCT) in children].
Dagmar Honnef (2008)
10.1016/j.lungcan.2013.07.006
Inter-observer reproducibility of semi-automatic tumor diameter measurement and volumetric analysis in patients with lung cancer.
J. Dinkel (2013)
10.1016/j.ejrad.2010.11.001
Dual energy computed tomography of lung nodules: differentiation of iodine and calcium in artificial pulmonary nodules in vitro.
N. Knoess (2011)
10.1007/s00330-008-1243-z
Accuracy of MRI volume measurements of breast lesions: comparison between automated, semiautomated and manual assessment
M. Rominger (2008)
10.1183/09031936.00146110
Volumetry: an alternative to assess therapy response for malignant pleural mesothelioma?
T. Frauenfelder (2011)
Semantic Scholar Logo Some data provided by SemanticScholar