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One-Pot, Metal- And Azide-Free Synthesis Of 1,2,3-Triazoles From α-Ketoacetals And Amines

Luke R. Zehnder, Joel M. Hawkins, Scott C. Sutton

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An efficient one-pot two-step synthesis of 1,4-disubstituted 1,2,3-triazoles from α-ketoacetals and amines is presented. The method does not use metals, azides, or oxidants, and is compatible with a variety of functional groups, including heterocycles, esters, nitriles, and carbamates.