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Therapeutic Uses Of Botulinum Toxin.

J. Jankovic, M. Brin
Published 1991 · Medicine

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BOTULISM had been recognized by the 18th century, but the observation that a toxin produced by an anaerobic organism might be responsible for food poisoning was not made until 1897.1 Although seven immunologically distinct toxins have since been identified, only types A, B, and E have been linked to cases of botulism in humans.2 , 3 Botulinum toxin type A (hereafter referred to as botulinum toxin), one of the most lethal biologic toxins, has been found to be of therapeutic value in the treatment of a variety of neurologic and ophthalmologic disorders.4 The Food and Drug Administration recently approved botulinum toxin (Oculinum) . . .
This paper references
10.1111/j.1471-4159.1988.tb02482.x
Characterization of the Inhibitory Action of Botulinum Neurotoxin Type A on the Release of Several Transmitters from Rat Cerebrocortical Synaptosomes
A. C. Ashton (1988)
10.1001/ARCHNEUR.1986.00520090006004
Blepharospasm with basal ganglia lesions.
J. Jankovic (1986)
10.1288/00005537-198301000-00001
Adductor spastic dysphonia: Three years after recurrent laryngeal nerve resection
A. Aronson (1983)
10.1016/B978-0-12-644445-2.50013-1
CHAPTER 7 – Peripheral Actions of the Botulinum Toxins
L. Simpson (1989)
10.1016/S0140-6736(88)90188-2
TREATMENT OF ANISMUS IN INTRACTABLE CONSTIPATION WITH BOTULINUM A TOXIN
R. I. Hallan (1988)
10.1038/eye.1989.58
The role of botulinum toxin in the management of sixth nerve palsy
R. Fitzsimons (1989)
10.1016/S0161-6420(88)33163-5
Botulinum toxin A-induced protective ptosis in corneal disease.
C. Kirkness (1988)
10.1136/jnnp.51.12.1512
Dystonia and tremor induced by peripheral trauma: predisposing factors.
J. Jankovic (1988)
10.1212/WNL.40.8.1213
Double‐blind, placebo‐controlled trial of botulinum toxin injections for the treatment of spasmodic torticollis
P. Greene (1990)
10.1016/0140-6736(90)90263-5
Dose standardisation of botulinum toxin
E. Schantz (1990)
10.1212/WNL.41.2_Part_1.234
Essential tremor
J. S. Lou (1991)
10.1523/JNEUROSCI.09-08-02902.1989
Neurotransmission regulates stability of acetylcholine receptors at the neuromuscular junction
O. Avila (1989)
10.1136/PGMJ.65.762.208
Effect of treatment with botulinum toxin on spasticity.
T. K. Das (1989)
10.1212/WNL.37.4.616
Botulinum A toxin for cranial‐cervical dystonia
J. Jankovic (1987)
Etiology and differential diagnosis of blepharospasm and oromandibular dystonia.
J. Jankovic (1988)
10.1177/019459989010200205
Spasmodic Dysphonia: Botulinum Toxin Injection after Recurrent Nerve Surgery
C. Ludlow (1990)
10.1212/WNL.40.9.1332
Assessment: The clinical usefulness of botulinum toxin‐A in treating neurologic disorders
Lippincott Williams Wilkins (1990)
10.1136/jnnp.51.7.920
Botulinum toxin in spasmodic torticollis.
R. Stell (1988)
10.1001/ARCHOTOL.1987.01860060029009
Botulinum toxin injection of the vocal fold for spasmodic dysphonia. A preliminary report.
R. Miller (1987)
10.1212/WNL.36.2.160
Torsion dystonia
R. Burke (1986)
10.1212/WNL.40.2.381
Workshop on autoimmune neuropathies
A. Asbury (1990)
10.1128/JCM.19.5.645-648.1984
Detection of Clostridium botulinum type A toxin by enzyme-linked immunosorbent assay with antibodies produced in immunologically tolerant animals.
M. Dezfulian (1984)
10.1002/MDS.870040401
Adductor laryngeal dystonia (spastic dysphonia): Treatment with local injections of botulinum toxin (Botox)
M. Brin (1989)
Botulinum toxin treatment of blepharospasm.
Elston Js (1988)
10.1016/S0140-6736(86)92070-2
DOUBLE-BLIND STUDY OF BOTULINUM TOXIN IN SPASMODIC TORTICOLLIS
J. C. Tsui (1986)
Biochemical evidence for brain neurotransmitter changes in idiopathic torsion dystonia (dystonia musculorum deformans).
O. Hornykiewicz (1988)
10.1001/ARCHOPHT.1985.01050090057031
Hemifacial spasm treated with botulinum A toxin injection.
P. Savino (1985)
10.1016/0006-8993(83)91300-8
Botulinum toxin blocks quantal but not non-quantal release of ACh at the neuromuscular junction
E. F. Stanley (1983)
10.1017/S0317167100027748
Botulinum toxin injections in the treatment of blepharospasm, hemifacial spasm, and eyelid fasciculations.
S. Kraft (1988)
10.1126/SCIENCE.785600
Botulinum toxin: mechanism of presynaptic blockade.
I. Kao (1976)
10.1016/0002-9394(88)90016-5
Negative antibody response to long-term treatment of facial spasm with botulinum toxin.
R. Gonnering (1988)
10.1002/ANA.410230740
HTLV‐I, Adult T‐Cell leukemia, and tropical spastic paraparesis
P. Sarin (1988)
10.1001/ARCHOPHT.1985.01050030043017
Botulinum A toxin injection as a treatment for blepharospasm.
A. Scott (1985)
10.1136/jnnp.53.8.640
Botulinum toxin treatment in spasmodic torticollis.
J. Blackie (1990)
10.1002/MDS.870030107
Analysis of open‐label trials in torsion dystonia using high dosages of anticholinergics and other drugs
P. Greene (1988)
10.1001/ARCHOPHT.1990.01070040101040
Familial hemifacial spasm.
J. Carter (1990)
10.1212/WNL.39.1.80
Controlled trial of botulinum toxin injections in the treatment of spasmodic torticollis
D. Gelb (1989)
10.1007/BF00500319
Effects of type a botulinum toxin on the cholinergic transmission at spinal renshaw cells and on the inhibitory action at ia inhibitory interneurones
R. Hagenah (2004)
10.1212/WNL.38.8.1220
Effects of botulinum toxin injections on speech in adductor spasmodic dysphonia
C. Ludlow (1988)
10.1093/INFDIS/150.3.407
Antitoxin levels in botulism patients treated with trivalent equine botulism antitoxin to toxin types A, B, and E.
C. H. Hatheway (1984)
10.1177/000348948909800202
Botulinum Toxin Injection for the Treatment of Oromandibular Dystonia
A. Blitzer (1989)
10.1097/00002341-199103000-00007
Innervation Zone of Orbicularis Oculi Muscle and Implications for Botulinum A Toxin Therapy
G. Borodic (1991)
10.1212/WNL.38.3.391
Tetrabenazine therapy of dystonia, chorea, tics, and other dyskinesias
J. Jankovic (1988)
10.1212/WNL.40.2.277
Botulinum toxin injections for cervical dystonia
J. Jankovic (1990)
Hemifacial spasm: differential diagnosis, mechanism, and treatment.
K. Digre (1988)
10.1016/S0161-6420(88)32977-5
Long-term results and complications of botulinum A toxin in the treatment of blepharospasm.
J. Dutton (1988)
10.1002/ANA.410280407
Treatment of spasticity with botulinum toxin: A double‐blind study
B. Snow (1990)
10.1212/WNL.41.2_Part_1.174
Dopa‐responsive dystonia
T. Nygaard (1991)
Progressive supranuclear palsy: motor, neurobehavioral, and neuro-ophthalmic findings.
J. Jankovic (1990)
10.1016/S0161-6420(89)32777-1
Chemodenervation of strabismic children. A 2- to 5-year follow-up study compared with shorter follow-up.
E. Magoon (1989)
10.1016/S0140-6736(89)92551-8
DOSE STANDARDISATION OF BOTULINUM TOXIN
N. Quinn (1989)
10.1136/BJO.72.5.361
Treatment of senile entropion with botulinum toxin.
J. Clarke (1988)
10.1016/0014-4800(67)90007-X
Experimental botulism in monkeys--a clinical pathological study.
B. A. Herrero (1967)
10.1212/WNL.38.4.522
Focal task‐specific tremor and dystonia
F. Rosenbaum (1988)
10.1136/jnnp.51.6.767
Blepharospasm: a review of 264 patients.
F. Grandas (1988)
10.1001/ARCHOPHT.1989.01070010842025
Vertical rectus muscle transposition and botulinum toxin (Oculinum) to medial rectus for abducens palsy.
A. Rosenbaum (1989)
10.1016/S0161-6420(89)32776-X
Management of strabismus with botulinum A toxin.
A. W. Biglan (1989)
10.1016/0022-510X(89)90135-4
Early terminal and nodal sprouting of motor axons after botulinum toxin
R. Pamphlett (1989)
10.1288/00005537-198802000-00015
Localized injections of botulinum toxin for the treatment of focal laryngeal dystonia (spastic dysphonia)
A. Blitzer (1988)
10.1001/ARCHNEUR.1990.00530050070014
Natural history of adult-onset idiopathic torticollis.
M. Jahanshahi (1990)
10.1002/MDS.870020402
Localized injections of botulinum toxin for the treatment of focal dystonia and hemifacial spasm
M. Brin (1987)
Treatment of detrusor-sphincter dyssynergia with botulinum A toxin: a double-blind study.
D. Dykstra (1990)
Botulinum toxin injection therapy for hemifacial spasm.
E. Tolosa (1988)
10.1016/0166-2236(90)90007-W
Writer's cramp
C. Marsden (1990)
10.1016/B978-0-12-644445-2.50008-8
CHAPTER 3 – The Structure of Botulinum Neurotoxin
B. Dasgupta (1989)
10.1093/CLINIDS/1.4.701
A New Anaerobic Bacillus and Its Relation to Botulism
E. V. Ermengem (1979)
10.1002/MDS.870030409
Systemic toxicity of botulinum toxin by intramuscular injection in the monkey
A. B. Scott (1988)
10.1002/ANA.410280509
Eyelid movements before and after botulinum therapy in patients with lid spasm
K. Manning (1990)
Selective peripheral denervation in 111 cases of spasmodic torticollis: rationale and results.
C. Bertrand (1988)
10.1136/jnnp.53.8.633
Botulinum toxin treatment of cranial-cervical dystonia, spasmodic dysphonia, other focal dystonias and hemifacial spasm.
J. Jankovic (1990)
10.3171/JNS.1977.47.3.0321
Etiology and definitive microsurgical treatment of hemifacial spasm. Operative techniques and results in 47 patients.
P. Jannetta (1977)
10.1177/000348947608500405
Recurrent Laryngeal Nerve Section for Spastic Dysphonia
H. Dedo (1976)
10.1016/0896-6273(89)90188-8
Human gene for torsion dystonia located on chromosome 9q32-q34
L. Ozelius (1989)
10.1016/S0161-6420(80)35127-0
Botulinum toxin injection into extraocular muscles as an alternative to strabismus surgery.
A. B. Scott (1980)
10.1016/S0002-9394(14)74342-9
Botulinum therapy for apraxia of eyelid opening.
B. Katz (1987)
10.1136/jnnp.52.3.355
Treatment of focal dystonias of the hand with botulinum toxin injections.
L. Cohen (1989)
10.1038/264787A0
Effect of botulinum toxin on trophic regulation of acetycholine receptors
A. Pestronk (1976)
10.1002/MUS.880120904
Botulinum toxin therapy in hemifacial spasm: Clinical and electrophysiologic studies
B. D. Geller (1989)
10.1038/eye.1988.5
Clostridium botulinum toxins: nature and preparation for clinical use
J. Melling (1988)
10.1016/S0161-6420(86)33713-8
Botolinum Toxin for the Treatment of Dysthyrolod Ocular Myopathy
W. J. Dunn (1986)
10.1136/jnnp.49.7.827
Botulinum toxin treatment of hemifacial spasm.
J. Elston (1986)
10.1016/0002-9394(88)90590-9
Treatment of acquired nystagmus with botulinum A toxin.
E. Helveston (1988)
10.1016/S0161-6420(87)33337-8
Use of botulinum toxin in the treatment of one hundred patients with facial dyskinesias.
J. Mauriello (1987)
10.1002/MDS.870060110
Writer's cramp: Treatment with botulinum toxin injections
J. Rivest (1991)
10.1212/WNL.40.2.382
Limbic encephalitis associated with thymoma
Gary G. Zngenito (1990)



This paper is referenced by
10.1016/S0213-9251(02)72595-1
Uso de la toxina botulínica en dermatología, ¿todo son éxitos?
P. Olasolo (2002)
10.1016/S1040-0486(03)70003-9
Introduction to cosmetic dermatology
Michelle L. Bennett (2003)
Tratamiento del Síndrome de Dolor Miofascial con Toxina Botulínica tipo A
M. Castro (2006)
10.1177/000348940010900215
Effects of Botulinum Toxin on Pathophysiology in Spasmodic Dysphonia
S. Bielamowicz (2000)
10.2147/TCRM.S94193
Evidence-based treatments for cluster headache
R. Gooriah (2015)
10.1016/j.joms.2006.11.028
Oromandibular dystonia revisited: a review and a unique case.
R. Balasubramaniam (2008)
10.1212/WNL.50.2.485
Skeletal muscle‐specific immunotoxin for the treatment of focal muscle spasm
J. Hott (1998)
4. Motor and Sensory Impairment Remediation Post Acquired Brain Injury
Shawn Marshall (2014)
Factors affecting the health-related quality of life of patients with cervical dystonia and the impact of botulinum toxin type A injections.
J. Slawek (2007)
10.1177/019459989811800404
Botulinum Toxin Decreases Salivation from Canine Submandibular Glands
C. M. Shaari (1998)
10.1016/S0887-8994(03)00269-8
The use of botulinum toxin type A treatment in children with spasticity.
B. Sarioğlu (2003)
10.1185/030079904125003962
Safety of botulinum toxin type A: a systematic review and meta-analysis
M. Naumann (2004)
Botulinum toxins in dentistry--the new paradigm for masticatory muscle hypertonicity.
H. Katz (2005)
10.1152/AJPGI.00296.2002
Inhibitory effects of botulinum toxin on pyloric and antral smooth muscle.
A. N. James (2003)
10.1016/J.JPEDSURG.2006.12.045
Botulinum toxin, a new treatment modality for chronic idiopathic constipation in children: long-term follow-up of a double-blind randomized trial.
A. Keshtgar (2007)
10.1212/WNL.48.1.253
Autosomal Dominant Hyaline Body Myopathy Presenting As Scapuloperoneal Syndrome
S. Masuzugawa (1997)
10.1007/978-3-0348-9057-1_6
Translocation of bacterial protein toxins across membranes
C. Montecucco (1995)
10.1002/mds.20859
Coronoidotomy as treatment for trismus due to jaw‐closing oromandibular dystonia
K. Yoshida (2006)
10.1056/NEJM199801223380410
Pharmacologic therapy for anal fissure.
R. Madoff (1998)
10.1007/978-1-4757-9542-4_71
The Usefulness of Electromyography (EMG) in Botulinum Toxin Treatment of Cervical Dystonia
C. Comella (1993)
10.1002/MDS.870130613
Effect of dystonia and botulinum toxin treatment on health‐related quality of life
C. Gudex (1998)
10.1016/S0892-1997(96)80026-9
Abnormal soft palate posturing in patients with laryngeal movement disorders.
D. Lundy (1996)
10.1592/phco.20.13.1079.35040
Pharmacotherapy with Botulinum Toxin: Harnessing Nature's Most Potent Neurotoxin
M. Bell (2000)
10.1097/00002826-200007000-00003
Mexiletine in the Treatment of Torticollis and Generalized Dystonia
C. Lucetti (2000)
10.1097/00005176-200005000-00009
Evaluation of the use of botulinum toxin in children with achalasia.
M. Hurwitz (2000)
10.1093/BRAIN/121.5.977
The corticomotor representation of upper limb muscles in writer's cramp and changes following botulinum toxin injection.
M. Byrnes (1998)
The effect of doxorubicin on skeletal muscle: an experimental study
E. Çullu (2000)
10.2174/1874076600903010014
Therapeutic Application of Botulinum Toxin in Clinical Practice
S. Dash (2009)
10.1002/MDS.870130330
Extensor truncal dystonia: Successful treatment with botulinum toxin injections
C. Comella (1998)
10.1002/1531-8257(200001)15:1<150::AID-MDS1024>3.0.CO;2-X
Patients' perception of stopping or continuing treatment of cervical dystonia with botulinum toxin type A
A. Brashear (2000)
10.1016/S1388-2457(01)00478-3
Remote F-wave changes after local botulinum toxin application
K. Wohlfarth (2001)
10.2165/00002018-199411030-00001
New Concepts in Botulinum Toxin Therapy
G. Borodic (1994)
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