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A Comparison Of Balloon-expandable-stent Implantation With Balloon Angioplasty In Patients With Coronary Artery Disease. Benestent Study Group.

P. W. Serruys, Peter J de Jaegere, Ferdinand Kiemeneij, Carlos Marcelino Díaz Macaya, Wolfgang Rutsch, Gr. Heyndrickx, Håkan Emanuelsson, Jean Marco, Victor Legrand, Phillipe Materne
Published 1994 · Medicine
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BACKGROUND Balloon-expandable coronary-artery stents were developed to prevent coronary restenosis after coronary angioplasty. These devices hold coronary vessels open at sites that have been dilated. However, it is unknown whether stenting improves long-term angiographic and clinical outcomes as compared with standard balloon angioplasty. METHODS A total of 520 patients with stable angina and a single coronary-artery lesion were randomly assigned to either stent implantation (262 patients) or standard balloon angioplasty (258 patients). The primary clinical end points were death, the occurrence of a cerebrovascular accident, myocardial infarction, the need for coronary-artery bypass surgery, or a second percutaneous intervention involving the previously treated lesion, either at the time of the initial procedure or during the subsequent seven months. The primary angiographic end point was the minimal luminal diameter at follow-up, as determined by quantitative coronary angiography. RESULTS After exclusions, 52 patients in the stent group (20 percent) and 76 patients in the angioplasty group (30 percent) reached a primary clinical end point (relative risk, 0.68; 95 percent confidence interval, 0.50 to 0.92; P = 0.02). The difference in clinical-event rates was explained mainly by a reduced need for a second coronary angioplasty in the stent group (relative risk, 0.58; 95 percent confidence interval, 0.40 to 0.85; P = 0.005). The mean (+/- SD) minimal luminal diameters immediately after the procedure were 2.48 +/- 0.39 mm in the stent group and 2.05 +/- 0.33 mm in the angioplasty group; at follow-up, the diameters were 1.82 +/- 0.64 mm in the stent group and 1.73 +/- 0.55 mm in the angioplasty group (P = 0.09), which correspond to rates of restenosis (diameter of stenosis, > or = 50 percent) of 22 and 32 percent, respectively (P = 0.02). Peripheral vascular complications necessitating surgery, blood transfusion, or both were more frequent after stenting than after balloon angioplasty (13.5 vs. 3.1 percent, P < 0.001). The mean hospital stay was significantly longer in the stent group than in the angioplasty group (8.5 vs. 3.1 days, P < 0.001). CONCLUSIONS Over seven months of follow-up, the clinical and angiographic outcomes were better in patients who received a stent than in those who received standard coronary angioplasty. However, this benefit was achieved at the cost of a significantly higher risk of vascular complications at the access site and a longer hospital stay.

This paper is referenced by
Prior cytomegalovirus infection and the risk of restenosis after percutaneous transluminal coronary balloon angioplasty.
Christoph Manegold (1999)
Intracoronary beta-radiation to reduce restenosis after balloon angioplasty and stenting; the Beta Radiation In Europe (BRIE) study.
P. W. Serruys (2002)
Beneficial effects of fluvastatin following percutaneous coronary intervention in patients with unstable and stable angina: results from the Lescol intervention prevention study (LIPS)
Chi Hang Lee (2004)
The battle of vladimir.
Jaap N. Hamburger (2000)
Angiographic patterns of in-stent restenosis and implications on subsequent revascularization.
A Kini (2000)
Short-term outcome of percutaneous coronary intervention with directional coronary atherectomy followed by drug-coated balloon: a preliminary report
A. Sato (2018)
Drug Delivery Coatings for Coronary Stents
Shrirang V. Ranade (2016)
Clinical Outcomes in Low Risk Coronary Artery Disease Patients Treated with Different Limus-Based Drug-Eluting Stents - A Nationwide Retrospective Cohort Study Using Insurance Claims Database
Chao-Lun Lai (2015)
Overview of the 2007 Food and Drug Administration Circulatory System Devices Panel Meeting on the Endeavor Zotarolimus-Eluting Coronary Stent
Tina L Pinto Slottow (2008)
Drug-Eluting Stent and Coronary Thrombosis: Biological Mechanisms and Clinical Implications
Thomas F Lüscher (2007)
Non–Polymer-Based Paclitaxel-Coated Coronary Stents for the Treatment of Patients With De Novo Coronary Lesions: Angiographic Follow-Up of the DELIVER Clinical Trial
Alexandra J Lansky (2004)
Analysis of 1-Year Clinical Outcomes in the SIRIUS Trial: A Randomized Trial of a Sirolimus-Eluting Stent Versus a Standard Stent in Patients at High Risk for Coronary Restenosis
David R Holmes (2004)
Development of Hydrophobized Alginate Hydrogels for the Vessel-Simulating Flow-Through Cell and Their Usage for Biorelevant Drug-Eluting Stent Testing
Beatrice Semmling (2013)
Fracture‐Resistant and Bioresorbable Drug‐Eluting Poly(glycerol Sebacate) Coils
Kamyar Mollazadeh-Moghaddam (2019)
Coronary hemodynamics of stent implantation after suboptimal and optimal balloon angioplasty.
Michiel D Voskuil (2002)
Koronare Stents / Von der Idee zum High–Tech–Implantat
Heinrich Wieneke (2005)
Estrogen-Eluting Stents
Sung Kee Ryu (2009)
Limitations and Long Term Outcome of Intracoronary Radiation Therapy With Catheter Based Systems and Radioactive Stents
Georgios Sianos (2003)
Drug-eluting stent coatings Review
Xiaodong Ma (2012)
FX minirail balloon angioplasty for the treatment of patients with in-stent restenosis: a matched comparison of 6 months’ outcome with conventional balloon angioplasty
Oben Döven (2004)
Dual Antiplatelet Therapy (DAPT) in Coronary Artery Disease: A Daunting Dilemma
Suryateja Chaturvedula (2018)
Understanding and minimizing late thrombosis of drug-eluting stents.
Mark Rabbat (2007)
Medizinische Fakultät
Najib Al-Abdulrazzak (2002)
Restenose-Prädiktoren nach Stent-Implantation aortokoronarvenöser Bypassgefäße
Ulrich E. Heidland (2000)
Uso de stent liberador de droga para el tratamiento de la reestenosis intrastent en la práctica diaria. Resultados de un centro de alto volumen de la Argentina
Mariano Albertal (2007)
Segurança e eficácia dos stents farmacológicos: uma pausa para reflexão
Luiz Antonio Ferreira Carvalho (2006)
Reestenosis, trombosis de stent y complicaciones hemorrágicas. Navegar entre Escila y Caribdis
Juan José Torrado (2018)
Durchflußzytometrisch nachgewiesene Aktivierung von Thrombozyten im Verlauf der Rotablation
Juliane Bau (2000)
Intravascular ultrasound-guided percutaneous transluminal coronary angioplasty with provisional spot stenting for treatment of long coronary lesions.
Antonio Colombo (2001)
Mechanical suitability of an endovascular braincomputer interface
Nicholas L. Opie (2020)
Intravascular stent implantation of the celiac artery in the treatment of chronic mesenteric ischemia.
Israel Gotsman (2001)
Novel, vessel anatomy adjusting drug-coated balloon-Preclinical evaluation in peripheral porcine arteries.
Stephanie Bienek (2019)
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