Online citations, reference lists, and bibliographies.
← Back to Search

Capture And Release Of Cancer Cells Using Electrospun Etchable MnO2 Nanofibers Integrated In Microchannels

Hui-qin Liu, Xiaolei Yu, B. Cai, Sujian You, Zhaobo He, Qinqin Huang, L. Rao, S. Li, Chang Liu, Weiwei Sun, W. Liu, Shishang Guo, X. Zhao
Published 2015 · Materials Science

Cite This
Download PDF
Analyze on Scholarcy
Share
This paper introduces a cancer cell capture/release microchip based on the self-sacrificed MnO2 nanofibers. Through electrospinning, lift-off and soft-lithography procedures, MnO2 nanofibers are tactfully fabricated in microchannels to implement enrichment and release of cancer cells in liquid samples. The MnO2 nanofiber net which mimics the extra cellular matrix can lead to high capture ability with the help of a cancer cell-specific antibody bio-conjugation. Subsequently, an effective and friendly release method is carried out by using low concentration of oxalic acid to dissolve the MnO2 nanofiber substrate while keeping high viability of those released cancer cells at the same time. It is conceivable that our microchip may have potentials in realizing biomedical analysis of circulating tumor cells for biological and clinical researches in oncology.
This paper references
10.1002/adma.201200155
Electrospun TiO2 nanofiber-based cell capture assay for detecting circulating tumor cells from colorectal and gastric cancer patients.
Nangang Zhang (2012)
10.1002/adma.201205237
High-purity prostate circulating tumor cell isolation by a polymer nanofiber-embedded microchip for whole exome sequencing.
L. Zhao (2013)
10.1146/annurev.anchem.111808.073610
Microsystems for the capture of low-abundance cells.
U. Dharmasiri (2010)
10.1002/smll.201400719
A radial flow microfluidic device for ultra-high-throughput affinity-based isolation of circulating tumor cells.
Vasudha Murlidhar (2014)
10.1002/smll.201300169
Magneto-controllable capture and release of cancer cells by using a micropillar device decorated with graphite oxide-coated magnetic nanoparticles.
Xiaolei Yu (2013)
10.1002/adma.201101724
Electronic control of cell detachment using a self-doped conducting polymer.
Kristin M Persson (2011)
10.1039/c3cs60419e
Three-dimensional nano-biointerface as a new platform for guiding cell fate.
Xueli Liu (2014)
10.1002/adhm.201300670
Capture and release of cancer cells based on sacrificeable transparent MnO2 nanospheres thin film.
Qinqin Huang (2014)
10.1002/anie.201208452
Polymer nanofiber-embedded microchips for detection, isolation, and molecular analysis of single circulating melanoma cells.
Shuang Hou (2013)
10.1038/16898
A controlled-release microchip
J. T. Santini (1999)
10.1039/c4lc00903g
Standing surface acoustic wave (SSAW)-based cell washing.
Sixing Li (2015)
10.1038/nature06385
Isolation of rare circulating tumour cells in cancer patients by microchip technology
S. Nagrath (2007)
10.1038/nm1469
Tumor metastasis: mechanistic insights and clinical challenges
P. Steeg (2006)
10.1039/c3lc51139a
Standing surface acoustic wave (SSAW)-based microfluidic cytometer.
Y. Chen (2014)
10.1056/NEJMOA040766
Circulating tumor cells, disease progression, and survival in metastatic breast cancer.
M. Cristofanilli (2004)
10.1016/J.HUMPATH.2006.01.026
Isolation by size of epithelial tumor cells in peripheral blood of patients with breast cancer: correlation with real-time reverse transcriptase-polymerase chain reaction results and feasibility of molecular analysis by laser microdissection.
P. Pinzani (2006)
10.1002/adma.201403530
Aptamer-functionalized barcode particles for the capture and detection of multiple types of circulating tumor cells.
Fuyin Zheng (2014)
10.1039/c3cs60426h
Nanoparticles meet electrospinning: recent advances and future prospects.
Chuan-ling Zhang (2014)
10.1002/adma.201300082
Specific capture and release of circulating tumor cells using aptamer-modified nanosubstrates.
Q. Shen (2013)
10.1038/nature13118
The present and future role of microfluidics in biomedical research
E. Sackmann (2014)
10.1038/nature06913
The cancer biomarker problem
C. Sawyers (2008)
10.1039/C3TA11727H
Flexible supercapacitor based on MnO2 nanoparticles via electrospinning
X. Li (2013)
10.1002/adma.201203826
Hydrophobic interaction-mediated capture and release of cancer cells on thermoresponsive nanostructured surfaces.
Hongliang Liu (2013)
10.1039/c2lc90148j
Probing circulating tumor cells in microfluidics.
P. Li (2013)
10.1093/jnci/djn419
Anti-Epithelial Cell Adhesion Molecule Antibodies and the Detection of Circulating Normal-Like Breast Tumor Cells
A. Sieuwerts (2009)



This paper is referenced by
10.1007/978-3-030-39994-8_4
Magnetic Responsive MnO 2 Nanomaterials
Wen-xian Li (2020)
10.1002/adma.201903663
Nanostructured Substrates for Detection and Characterization of Circulating Rare Cells: From Materials Research to Clinical Applications.
Jiantong Dong (2019)
10.1115/1.4030420
Nanotopographic Biomaterials for Isolation of Circulating Tumor Cells
Weiyi Qian (2014)
10.1016/J.SNB.2017.05.032
Stably electro-switchable poly-allyloxy hydroxypropyl sulfonate branched brush towards reversible capture and release of proteins and cells
H. Zeng (2017)
10.1002/SMTD.201800544
Beyond Capture: Circulating Tumor Cell Release and Single‐Cell Analysis
L. Wu (2019)
10.1016/j.colsurfb.2017.07.081
Synthesis and characterization of hyaluronic acid coated manganese dioxide microparticles that act as ROS scavengers.
J. Bizeau (2017)
10.1039/C9RA05012D
Electrospun fibers and their application in drug controlled release, biological dressings, tissue repair, and enzyme immobilization
Sun Yue (2019)
10.1007/978-3-030-39994-8
Responsive Nanomaterials for Sustainable Applications
Ziqi Sun (2020)
10.1016/J.CPLETT.2016.12.014
Effective capture and release of circulating tumor cells using core-shell Fe 3 O 4 @MnO 2 nanoparticles
L. Xiao (2017)
10.1007/978-3-319-70049-6_6
Electrospun Biomaterials for Cancer Research
Akshay A Narkhede (2017)
10.1039/C7TB03347H
Design of functional electrospun nanofibers for cancer cell capture applications.
Yunchao Xiao (2018)
10.1002/PPSC.201900076
Multifunctional Gelatin Nanoparticle Integrated Microchip for Enhanced Capture, Release, and Analysis of Circulating Tumor Cells
X. Wei (2019)
10.4155/fsoa-2016-0084
Microfluidic on-chip biomimicry for 3D cell culture: a fit-for-purpose investigation from the end user standpoint
Y. Liu (2017)
10.3390/polym12051117
Anti-Escherichia coli Functionalized Silver-Doped Carbon Nanofibers for Capture of E. coli in Microfluidic Systems
S. Smith (2020)
10.1109/TBME.2018.2875361
Highly Efficient Isolation of Circulating Tumor Cells Using a Simple Wedge-Shaped Microfluidic Device
Luman Qin (2019)
10.1039/c9tb02457c
Aptamer-based nanostructured interfaces for the detection and release of circulating tumor cells.
Pi Ding (2020)
10.1002/smll.201601275
Smart Thin Hydrogel Coatings Harnessing Hydrophobicity and Topography to Capture and Release Cancer Cells.
L. Wang (2016)
10.1039/C5RA11662G
Capturing hepatocellular carcinoma cells using lactobionic acid-functionalized electrospun polyvinyl alcohol/polyethyleneimine nanofibers
Yili Zhao (2015)
10.1039/d0nr04067c
Nanostructured manganese dioxide for anticancer applications: preparation, diagnosis, and therapy.
Z. Zhang (2020)
10.1039/C9TB00682F
Pivotal role of electrospun nanofibers in microfluidic diagnostic systems - a review.
Zahra Rezaei (2019)
10.1039/C6RA21477K
Recent advances in electrospun metal-oxide nanofiber based interfaces for electrochemical biosensing
K. Mondal (2016)
10.1016/J.TALANTA.2019.05.001
Rapid and efficient isolation and detection of circulating tumor cells based on ZnS:Mn2+ quantum dots and magnetic nanocomposites.
Heng Cui (2019)
10.1088/1361-6528/abb48b
Electrospun degradable Zn-Mn oxide hierarchical nanofibers for specific capture and efficient release of circulating tumor cells.
Longguang Xu (2020)
10.1088/2399-1984/AABF50
Size-amplified acoustofluidic separation of circulating tumor cells with removable microbeads
Huiqin Liu (2018)
10.1063/1.4937733
Highly sensitive microfluidic flow sensor based on aligned piezoelectric poly(vinylidene fluoride-trifluoroethylene) nanofibers
L. Zhang (2015)
10.1063/1.4943897
Ultraviolet-assisted microfluidic generation of ferroelectric composite particles.
C. Zhang (2016)
10.3390/mi11080774
Nanotechnology-Assisted Isolation and Analysis of Circulating Tumor Cells on Microfluidic Devices
J. Cheng (2020)
10.1021/acsami.5b06791
Capture and Release of Cancer Cells by Combining On-Chip Purification and Off-Chip Enzymatic Treatment.
Xiaolei Yu (2015)
10.1039/C5TA05523G
MnO2-based nanostructures for high-performance supercapacitors
M. Huang (2015)
Semantic Scholar Logo Some data provided by SemanticScholar