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Capture And Release Of Cancer Cells Using Electrospun Etchable MnO2 Nanofibers Integrated In Microchannels
Hui-qin Liu, Xiaolei Yu, B. Cai, Sujian You, Zhaobo He, Qinqin Huang, L. Rao, S. Li, Chang Liu, Weiwei Sun, W. Liu, Shishang Guo, X. Zhao
Published 2015 · Materials Science
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This paper introduces a cancer cell capture/release microchip based on the self-sacrificed MnO2 nanofibers. Through electrospinning, lift-off and soft-lithography procedures, MnO2 nanofibers are tactfully fabricated in microchannels to implement enrichment and release of cancer cells in liquid samples. The MnO2 nanofiber net which mimics the extra cellular matrix can lead to high capture ability with the help of a cancer cell-specific antibody bio-conjugation. Subsequently, an effective and friendly release method is carried out by using low concentration of oxalic acid to dissolve the MnO2 nanofiber substrate while keeping high viability of those released cancer cells at the same time. It is conceivable that our microchip may have potentials in realizing biomedical analysis of circulating tumor cells for biological and clinical researches in oncology.
This paper references
Electrospun TiO2 nanofiber-based cell capture assay for detecting circulating tumor cells from colorectal and gastric cancer patients.
Nangang Zhang (2012)
High-purity prostate circulating tumor cell isolation by a polymer nanofiber-embedded microchip for whole exome sequencing.
L. Zhao (2013)
Microsystems for the capture of low-abundance cells.
U. Dharmasiri (2010)
A radial flow microfluidic device for ultra-high-throughput affinity-based isolation of circulating tumor cells.
Vasudha Murlidhar (2014)
Magneto-controllable capture and release of cancer cells by using a micropillar device decorated with graphite oxide-coated magnetic nanoparticles.
Xiaolei Yu (2013)
Electronic control of cell detachment using a self-doped conducting polymer.
Kristin M Persson (2011)
Three-dimensional nano-biointerface as a new platform for guiding cell fate.
Xueli Liu (2014)
Capture and release of cancer cells based on sacrificeable transparent MnO2 nanospheres thin film.
Qinqin Huang (2014)
Polymer nanofiber-embedded microchips for detection, isolation, and molecular analysis of single circulating melanoma cells.
Shuang Hou (2013)
A controlled-release microchip
J. T. Santini (1999)
Standing surface acoustic wave (SSAW)-based cell washing.
Sixing Li (2015)
Isolation of rare circulating tumour cells in cancer patients by microchip technology
S. Nagrath (2007)
Tumor metastasis: mechanistic insights and clinical challenges
P. Steeg (2006)
Standing surface acoustic wave (SSAW)-based microfluidic cytometer.
Y. Chen (2014)
Circulating tumor cells, disease progression, and survival in metastatic breast cancer.
M. Cristofanilli (2004)
Isolation by size of epithelial tumor cells in peripheral blood of patients with breast cancer: correlation with real-time reverse transcriptase-polymerase chain reaction results and feasibility of molecular analysis by laser microdissection.
P. Pinzani (2006)
Aptamer-functionalized barcode particles for the capture and detection of multiple types of circulating tumor cells.
Fuyin Zheng (2014)
Nanoparticles meet electrospinning: recent advances and future prospects.
Chuan-ling Zhang (2014)
Specific capture and release of circulating tumor cells using aptamer-modified nanosubstrates.
Q. Shen (2013)
The present and future role of microfluidics in biomedical research
E. Sackmann (2014)
The cancer biomarker problem
C. Sawyers (2008)
Flexible supercapacitor based on MnO2 nanoparticles via electrospinning
X. Li (2013)
Hydrophobic interaction-mediated capture and release of cancer cells on thermoresponsive nanostructured surfaces.
Hongliang Liu (2013)
Probing circulating tumor cells in microfluidics.
P. Li (2013)
Anti-Epithelial Cell Adhesion Molecule Antibodies and the Detection of Circulating Normal-Like Breast Tumor Cells
A. Sieuwerts (2009)
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Magnetic Responsive MnO 2 Nanomaterials
Wen-xian Li (2020)
Nanostructured Substrates for Detection and Characterization of Circulating Rare Cells: From Materials Research to Clinical Applications.
Jiantong Dong (2019)
Nanotopographic Biomaterials for Isolation of Circulating Tumor Cells
Weiyi Qian (2014)
Stably electro-switchable poly-allyloxy hydroxypropyl sulfonate branched brush towards reversible capture and release of proteins and cells
H. Zeng (2017)
Beyond Capture: Circulating Tumor Cell Release and Single‐Cell Analysis
L. Wu (2019)
Synthesis and characterization of hyaluronic acid coated manganese dioxide microparticles that act as ROS scavengers.
J. Bizeau (2017)
Electrospun fibers and their application in drug controlled release, biological dressings, tissue repair, and enzyme immobilization
Sun Yue (2019)
Responsive Nanomaterials for Sustainable Applications
Ziqi Sun (2020)
Effective capture and release of circulating tumor cells using core-shell Fe 3 O 4 @MnO 2 nanoparticles
L. Xiao (2017)
Electrospun Biomaterials for Cancer Research
Akshay A Narkhede (2017)
Design of functional electrospun nanofibers for cancer cell capture applications.
Yunchao Xiao (2018)
Multifunctional Gelatin Nanoparticle Integrated Microchip for Enhanced Capture, Release, and Analysis of Circulating Tumor Cells
X. Wei (2019)
Microfluidic on-chip biomimicry for 3D cell culture: a fit-for-purpose investigation from the end user standpoint
Y. Liu (2017)
Anti-Escherichia coli Functionalized Silver-Doped Carbon Nanofibers for Capture of E. coli in Microfluidic Systems
S. Smith (2020)
Highly Efficient Isolation of Circulating Tumor Cells Using a Simple Wedge-Shaped Microfluidic Device
Luman Qin (2019)
Aptamer-based nanostructured interfaces for the detection and release of circulating tumor cells.
Pi Ding (2020)
Smart Thin Hydrogel Coatings Harnessing Hydrophobicity and Topography to Capture and Release Cancer Cells.
L. Wang (2016)
Capturing hepatocellular carcinoma cells using lactobionic acid-functionalized electrospun polyvinyl alcohol/polyethyleneimine nanofibers
Yili Zhao (2015)
Nanostructured manganese dioxide for anticancer applications: preparation, diagnosis, and therapy.
Z. Zhang (2020)
Pivotal role of electrospun nanofibers in microfluidic diagnostic systems - a review.
Zahra Rezaei (2019)
Recent advances in electrospun metal-oxide nanofiber based interfaces for electrochemical biosensing
K. Mondal (2016)
Rapid and efficient isolation and detection of circulating tumor cells based on ZnS:Mn2+ quantum dots and magnetic nanocomposites.
Heng Cui (2019)
Electrospun degradable Zn-Mn oxide hierarchical nanofibers for specific capture and efficient release of circulating tumor cells.
Longguang Xu (2020)
Size-amplified acoustofluidic separation of circulating tumor cells with removable microbeads
Huiqin Liu (2018)
Highly sensitive microfluidic flow sensor based on aligned piezoelectric poly(vinylidene fluoride-trifluoroethylene) nanofibers
L. Zhang (2015)
Ultraviolet-assisted microfluidic generation of ferroelectric composite particles.
C. Zhang (2016)
Nanotechnology-Assisted Isolation and Analysis of Circulating Tumor Cells on Microfluidic Devices
J. Cheng (2020)
Capture and Release of Cancer Cells by Combining On-Chip Purification and Off-Chip Enzymatic Treatment.
Xiaolei Yu (2015)
MnO2-based nanostructures for high-performance supercapacitors
M. Huang (2015)