Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

Effect Of A Conjugate Of Daunomycin And Antibodies To Rat Alpha-fetoprotein On The Growth Of Alpha-fetoprotein-producing Tumor Cells.

Y. Tsukada, W. Bischof, N. Hibi, H. Hirai, E. Hurwitz, M. Sela
Published 1982 · Chemistry, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
Daunomycin was covalently attached via a dextran bridge to specific antibodies against rat alpha-fetoprotein produced in a horse. The effect of this conjugate on an alpha-fetoprotein-producing tumor was investigated in terms of cytotoxicity and inhibition or retardation of tumor development. Under the experimental conditions used, the covalent conjugate was by both criteria more efficient than either daunomycin alone or a mixture of daunomycin and specific antibodies or a conjugate of daunomycin with horse immunoglobulin. These results show that the conjugate may be useful as a specific cytotoxic agent against alpha-fetoprotein-producing tumors.



This paper is referenced by
10.1163/156856202320813846
Synthesis and biological properties of antitumor-active conjugates of ADR with dextran
Jan-An Guu (2002)
Immunoconjugates containing novel maytansinoids: promising anticancer drugs.
R. Chari (1992)
The use of daunomycin-antibody immunoconjugates in managing soft tissue sarcomas: nude mouse xenograft model.
J. J. Stastny (1993)
10.1007/BF02857213
Biodegradable polymeric drug delivery systems
S. Jeong (1986)
10.1038/bjc.1993.52
Chemotherapeutic efficacy of the protein-doxorubicin conjugates on multidrug resistant rat hepatoma cell line in vitro.
K. Ohkawa (1993)
10.1007/978-1-4613-1501-8_8
Pathophysiologic Basis for Brain Tumor Chemotherapy
J. A. Stephenson (1990)
10.1111/j.1349-7006.1991.tb01769.x
Comparative Pharmacokinetic Properties of Murine Monoclonal Antibody A7 Modified with Neocarzinostatin, Dextran and Polyethylene Glycol
K. Takashina (1991)
10.1016/0022-1759(87)90492-3
Preparation of 67Ga-labeled antibodies using deferoxamine as a bifunctional chelate. An improved method.
M. Koizumi (1987)
10.1002/IJC.2910410224
Conjugates of elliptinium acetate with mouse monoclonal anti‐α‐fetoprotein antibodies or fab fragments: In vitro cytotoxic effects upon human hepatoma cell lines
G. Alberici (1988)
10.1007/978-1-4613-1747-0_6
Daunomycin and doxorubicin Lym-1-drug conjugates for the treatment of malignant lymphomas.
F. Chen (1989)
10.1111/j.1348-0421.1992.tb02089.x
Monoclonal Antibodies against Human α‐Fetoprotein More Reactive to Cell‐Surface α‐Fetoprotein than to Free α‐Fetoprotein
K. Masuda (1992)
10.1111/j.1365-2710.1985.tb00715.x
DRUG TARGETING—CURRENT ASPECTS AND FUTURE PROSPECTS
C. Pouton (1985)
10.1080/14712598.2020.1757067
Sacituzumab govitecan, a novel, third-generation, antibody-drug conjugate (ADC) for cancer therapy
D. Goldenberg (2020)
10.1021/ac300551e
Microchip device with 64-site electrode array for multiplexed immunoassay of cell surface antigens based on electrochemiluminescence resonance energy transfer.
Meisheng Wu (2012)
10.1021/BC00014A016
Activation of mouse macrophages by muramyl dipeptide coupled with an anti-macrophage monoclonal antibody.
P. Midoux (1992)
10.1016/S0065-7743(08)60769-1
Chapter 14. Antineoplastic Agents
V. Marquez (1983)
10.1007/BF00199119
Evaluation of a conjugate of purified antibodies against human AFP-dextran-daunorubicin to human AFP-producing yolk sac tumor cell lines
K. Ohkawa (2004)
10.1016/S0169-409X(01)00227-7
Targeted drug conjugates: principles and progress.
M. Garnett (2001)
Bovine serum albumin-doxorubicin conjugate overcomes multidrug resistance in a rat hepatoma.
K. Ohkawa (1993)
10.1007/BF01952086
Selective killing of smooth muscle cells in culture by the ricin A-chain conjugated with monoclonal antibodies to a cell surface antigen via a dextran bridge
O. Y. Printseva (2005)
10.3109/10611869608996827
HPMA copolymer-anticancer drug-OV-TL16 antibody conjugates. 1. influence of the method of synthesis on the binding affinity to OVCAR-3 ovarian carcinoma cells in vitro.
V. Omelyanenko (1996)
10.1016/0163-7258(83)90029-3
Targeting potential of antibody conjugates.
D. C. Edwards (1983)
10.1007/BF01744941
Monoclonal antibody L6-daunomycin conjugates constructed to release free drug at the lower pH of tumor tissue
E. Lavie (2005)
10.1164/AJRCCM/139.6.1464
In vivo administration of glucose oxidase conjugated with monoclonal antibodies to angiotensin-converting enzyme. The tissue distribution, blood clearance, and targeting into rat lungs.
V. Muzykantov (1989)
10.1007/978-3-642-75862-1_5
Soluble Polymers as Targetable Drug Carriers
N. L. Krinick (1991)
10.1007/978-94-011-1428-8_5
Human Hepatoma Associated Antigens: Opportunities for Immunotherapy
D. Shouval (1994)
10.1016/S0079-6468(08)70410-7
Recent studies on doxorubicin and its analogues.
J. R. Brown (1984)
10.1002/JMR.639
Drug targeting by macromolecules without recognition unit?
F. Hudecz (2003)
10.1007/978-1-4613-2745-5_6
Synthesis, Characterization and Antitumor Activity of Macromolecular Prodrugs of Adriamycin
W. Heeswijk (1984)
10.1016/0192-0561(94)90085-X
Selective killing of tumor cells in vitro by immunotoxin composed of antitumor antibiotic streptonigrin and polyclonal specific antibodies.
S. Komissarenko (1994)
10.1016/S0065-230X(08)60483-2
Chemistry and biology of α-fetoprotein
H. Deutsch (1991)
10.1038/bjc.1991.124
Application of boronated anti-CEA immunoliposome to tumour cell growth inhibition in in vitro boron neutron capture therapy model.
H. Yanagië (1991)
See more
Semantic Scholar Logo Some data provided by SemanticScholar