Online citations, reference lists, and bibliographies.
← Back to Search

Atriopeptin Inhibition Of Thrombin-mediated Changes In The Morphology And Permeability Of Endothelial Monolayers.

D. Baron, C. E. Lofton, W. Newman, M. Currie
Published 1989 · Chemistry, Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
To determine the role of endothelial atriopeptin (AP) receptors, we examined the effect of AP-III on the morphology and macromolecular permeability of monolayer cultures of bovine aortic endothelial cells. AP-III alone (10(-9)-10(-6) M) had no observable effect on the morphology of the monolayers or their permeability to 125I-labeled albumin. However, incubation of the endothelial monolayers with AP-III (10(-8)-10(-6) M) antagonized thrombin-induced (1 unit/ml) cell-shape change and the formation of intercellular gaps. AP-III also opposed the effect of thrombin on the distribution of actin filaments in the endothelial cytoskeleton. Further, thrombin caused a 2-fold increase in monolayer permeability to 125I-labeled albumin, which was abolished by 10(-8)-10(-6) M AP-III pretreatment. Taken together with the findings that AP-III exhibited specific and saturable binding in these cells, these data suggest that AP regulates endothelial permeability through a receptor-mediated process.
This paper references



This paper is referenced by
10.1097/00003246-200207000-00029
Atrial natriuretic peptide improves pulmonary gas exchange by reducing extravascular lung water in canine model with oleic acid-induced pulmonary edema
C. Mitaka (2002)
10.1161/CIRCRESAHA.107.154229
Differential Regulation of Endothelial Cell Permeability by cGMP via Phosphodiesterases 2 and 3
J. Surapisitchat (2007)
10.1016/j.peptides.2004.08.034
The role of atrial natriuretic peptide in the immune system
A. Vollmar (2005)
10.1161/01.ATV.17.6.1018
Endothelial Permeability for Macromolecules Mechanistic Aspects of Pathophysiological Modulation
V. Hinsbergh (1997)
10.1378/CHEST.114.1.223
Beneficial effect of atrial natriuretic peptide on pulmonary gas exchange in patients with acute lung injury.
C. Mitaka (1998)
10.1097/00003246-199505000-00024
Protamine does not affect the formation of cGMP or cAMP in pig vascular smooth muscle cells in response to vasodilators.
M. Castresana (1995)
10.1111/j.1749-6632.1994.tb56828.x
Role of Glucocorticoids and “Caloric Stress” in Modulating the Effects of Caloric Restriction in Rodents a
J. Leakey (1994)
10.1161/01.RES.76.2.199
cGMP and nitric oxide modulate thrombin-induced endothelial permeability. Regulation via different pathways in human aortic and umbilical vein endothelial cells.
R. Draijer (1995)
10.1046/j.1469-7580.2002.00060.x
Intracellular signalling involved in modulating human endothelial barrier function*
Victor W. M. Van Hinsbergh (2002)
10.1016/S0014-2999(97)01203-X
Inhibitory effect of 2-phenyl-4-quinolone on serotonin-mediated changes in the morphology and permeability of endothelial monolayers.
H. Lee (1997)
10.1002/JCP.1041510309
Endothelium‐derived relaxing factor contributes to the regulation of endothelial permeability
J. Oliver (1992)
Biosynthesis, physiology and main diagnostic and therapeutic potentials of cardiac natriuretic peptides
Melpomeni Ntalapascha (2009)
10.1097/00003246-199602000-00021
Response of human artery, vein, and cultured smooth muscle cells to atrial and C-type natriuretic peptides.
L. Zhang (1996)
10.1007/BF00227877
Signalling by cGMP-dependent protein kinases
A. Vaandrager (2004)
10.1007/978-1-4899-0721-9_13
Mechanisms of Neutrophil Migration across Endothelium
A. Huang (1992)
10.1007/BF00123522
A method for isolating and culturing vascular smooth muscle cells from porcine cerebral arteries
H. Tao (1996)
10.1016/0014-5793(90)81143-C
Atrial natriuretic factor recognizes two receptor subtypes in endothelial cells cultured from bovine pulmonary artery
E. Redmond (1990)
10.1016/0922-4106(93)90021-Z
Induction of nitric oxide synthase regulates atrial natriuretic peptide receptors in vascular smooth muscle cells.
J. Kato (1993)
10.1152/AJPLUNG.2001.280.1.L116
Nitric oxide attenuates H(2)O(2)-induced endothelial barrier dysfunction: mechanisms of protection.
M. Gupta (2001)
Einfluss natriuretischer Peptide auf die endotheliale Glykokalyx
T. Saller (2012)
10.3349/ymj.2010.51.3.354
Effectiveness of Human Atrial Natriuretic Peptide Supplementation in Pulmonary Edema Patients Using the Pulse Contour Cardiac Output System
Y. Sakamoto (2010)
10.1016/0922-4106(92)90090-I
Suppression of atrial natriuretic peptide (ANP) receptor recovery from homologous down-regulation by 8-bromo-cGMP in endothelial cells.
J. Kato (1992)
10.1016/j.peptides.2013.07.020
Endothelial permeability in vitro and in vivo: Protective actions of ANP and omapatrilat in experimental atherosclerosis
T. Ichiki (2013)
10.1210/ENDO-129-5-2311
Glucocorticoid regulation of atrial natriuretic peptide receptors on cultured endothelial cells.
K. L. Lanier-Smith (1991)
10.1152/ajpheart.1998.275.5.H1818
Atrial natriuretic peptide clearance receptor participates in modulating endothelial permeability.
A. Hempel (1998)
10.1046/J.1469-7580.2002.00060.X
Intracellular signalling involved in modulating human endothelial barrier function
V. Hinsbergh (2002)
10.1097/00005344-199509000-00011
Pharmacologic Atrial Natriuretic Peptide Reduces Human Leg Capillary Filtration
D. Watenpaugh (1995)
10.1152/ajpheart.1998.275.5.H1818
Atrial natriuretic peptide clearance receptor participates in modulating endothelial permeability.
Albrecht Hempel (1998)
10.1213/00000539-199406000-00004
Tolerance to nitroglycerin in vascular smooth muscle cells: recovery and cross-tolerance to sodium nitroprusside.
L. Zhang (1994)
10.1063/1.4977584
Characterization of vascular permeability using a biomimetic microfluidic blood vessel model.
A. Thomas (2017)
10.3389/fendo.2014.00201
Natriuretic Hormones in Brain Function
Anastasia Hodes (2014)
10.1016/j.peptides.2004.09.022
Regulation of guanylyl cyclase/natriuretic peptide receptor-A gene expression
R. Garg (2005)
See more
Semantic Scholar Logo Some data provided by SemanticScholar