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Phosphatidate-dependent Protein Phosphorylation.

S. Bocckino, P. Wilson, J. Exton
Published 1991 · Biology, Medicine

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Phosphatidate-dependent protein phosphorylation was observed in soluble extracts from rat liver, brain, lung, and testis. The phosphorylation was stimulated by free Ca2+ in the range of 360-800 nM. Incubation mixtures containing phosphatidate provided markedly different profiles of protein phosphorylation from those with phosphatidylserine plus 1,2-diolein. Phosphatidate-dependent phosphorylation of a 30-kDa protein in the soluble fraction from heart was also observed. This phosphorylation did not require Ca2+. Soluble fractions from liver, testis, brain, and lung phosphorylated the 30-kDa heart protein in a phosphatidate-dependent Ca(2+)-independent manner. We propose that part of the action of phosphatidate in cells may be mediated by a protein kinase(s).



This paper is referenced by
Activation of phospholipase D by G protein-coupled receptors
D. McCulloch (1999)
10.1046/j.1460-9568.2003.02871.x
Nuclear localization of diacylglycerol kinase ζ in neurons
Y. Hozumi (2003)
10.1007/BFB0116585
Phospholipase D-structure, regulation and function.
J. Exton (2002)
10.1007/BF01208639
Increased phospholipase D activity in human breast cancer
N. Uchida (2005)
10.1016/S0005-2760(97)00201-4
Modulation of cell signalling by ceramides.
A. Gomez-Muñoz (1998)
10.3109/02713689408995782
Activation of phospholipase D by guanosine 5′[γ-thio]triphosphate and AlF−4 in bovine corneal epithelial cells
R. Akhtar (1994)
10.1074/JBC.271.17.10334
Phosphatidic Acid Generation through Interleukin 2 (IL-2)-induced -Diacylglycerol Kinase Activation Is an Essential Step in IL-2-mediated Lymphocyte Proliferation (*)
I. Flores (1996)
10.1016/S0952-3278(97)90498-1
Subcellular alterations in cardiac phospholipase D activity in chronic diabetes.
S. Williams (1997)
10.1096/fasebj.6.9.1612297
Regulation of phosphatidic acid phosphohydrolase activity during stimulation of human polymorphonuclear leukocytes
A. P. Truett Iii (1992)
10.1074/JBC.M002463200
Cardiac Phospholipase D2 Localizes to Sarcolemmal Membranes and Is Inhibited by α-Actinin in an ADP-ribosylation Factor-reversible Manner*
J. Park (2000)
10.1159/000081828
Regulation of Acetylcholine-Induced Phosphorylation of PLD1 in Porcine Tracheal Smooth Muscle
Abulkhair M. Mamoon (2004)
10.1002/JCP.1041650208
Stimulation of protein and DNA synthesis in mouse C2C12 satellite cells: Evidence for phospholipase d‐dependent and ‐independent pathways
K. S. Morrison (1995)
10.1016/0009-3084(96)02543-1
Sphingoid bases and phospholipase D activation.
S. Spiegel (1996)
10.1074/JBC.272.14.9503
Gene Cloning and Characterization of CDP-diacylglycerol Synthase from Rat Brain*
S. Saito (1997)
10.1002/JCP.1041560214
Platelet‐activating factor stimulates phosphatidic acid formation in cultured rat mesangial cells: Roles of phospholipase D, diglyceride kinase, and de novo phospholipid synthesis
M. Kester (1993)
Oxidative Stress, Nutritional Antioxidants, and Testosterone Secretion in Men
Glade Mj (2015)
10.1016/0009-3084(96)02548-0
Regulation of phospholipase D by tyrosine kinases.
V. Natarajan (1996)
10.1007/978-1-4615-5981-8_5
Oxidant-Mediated Activation of Phospholipases C and D
V. Natarajan (1997)
10.1152/AJPLUNG.00029.2002
Pulmonary phosphatidic acid phosphatase and lipid phosphate phosphohydrolase.
M. Nanjundan (2003)
10.1007/s00018-005-4531-7
Protein kinase C and phospholipase D: intimate interactions in intracellular signaling
K. P. Becker (2005)
10.1016/0009-3084(96)02549-2
Messenger functions of phosphatidic acid.
D. English (1996)
10.1002/jlb.58.2.189
Phorbol ester‐induced priming of superoxide generation by phosphatidic acid‐stimulated neutrophils and granule‐free neutrophil cytoplasts
R. Siddiqui (1995)
10.1016/0014-5793(93)81440-B
Enhancement of phospholipase A2 activation by phosphatidic acid endogenously formed through phospholipase D action in rat peritoneal mast cell
T. Sato (1993)
10.1152/AJPCELL.1993.264.4.C1045
Phorbol ester-stimulated exocytosis in lacrimal gland: PKC might not be the sole effector.
D. Zoukhri (1993)
10.1007/BF02536294
Leukotriene B4 stimulation of an early elevation of phosphatidic acid mass in human neutrophils
J. Tou (2006)
10.1016/0300-483X(95)03138-6
Inhibition by phospholipids, lysophospholipids and gangliosides of melittin-induced phosphorylation in bovine mammary gland.
N. Katoh (1995)
10.1074/jbc.272.24.15569
Phosphatidic Acid-mediated Phosphorylation of the NADPH Oxidase Component p47-phox
K. Waite (1997)
Advances in Brief Activation of Phospholipase D Participates in Signal Transduction Pathways Responsive to ' y-Radiation
Matías A. Avila (2007)
10.1074/JBC.270.33.19422
Purification and Characterization of a Novel Plasma Membrane Phosphatidate Phosphohydrolase from Rat Liver (*)
D. W. Waggoner (1995)
10.1161/01.RES.71.4.970
Depression of cardiac sarcolemmal phospholipase D activity by oxidant-induced thiol modification.
J. Dai (1992)
10.1016/0014-5793(93)81209-I
GTPγS and phorbol ester act synergistically to stimulate both Ca2+‐independent secretion and phospholipase D activity in permeabilized human platelets
J. Coorssen (1993)
10.1016/S1054-3589(08)60932-1
Insulin mediators and the mechanism of insulin action.
G. Romero (1993)
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