Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

Transdermal Photopolymerization For Minimally Invasive Implantation.

J. Elisseeff, K. Anseth, D. Sims, W. McIntosh, M. Randolph, R. Langer
Published 1999 · Materials Science, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
Photopolymerizations are widely used in medicine to create polymer networks for use in applications such as bone restorations and coatings for artificial implants. These photopolymerizations occur by directly exposing materials to light in "open" environments such as the oral cavity or during invasive procedures such as surgery. We hypothesized that light, which penetrates tissue including skin, could cause a photopolymerization indirectly. Liquid materials then could be injected s.c. and solidified by exposing the exterior surface of the skin to light. To test this hypothesis, the penetration of UVA and visible light through skin was studied. Modeling predicted the feasibility of transdermal polymerization with only 2 min of light exposure required to photopolymerize an implant underneath human skin. To establish the validity of these modeling studies, transdermal photopolymerization first was applied to tissue engineering by using "injectable" cartilage as a model system. Polymer/chondrocyte constructs were injected s.c. and transdermally photopolymerized. Implants harvested at 2, 4, and 7 weeks demonstrated collagen and proteoglycan production and histology with tissue structure comparable to native neocartilage. To further examine this phenomenon and test the applicability of transdermal photopolymerization for drug release devices, albumin, a model protein, was released for 1 week from photopolymerized hydrogels. With further study, transdermal photpolymerization potentially could be used to create a variety of new, minimally invasive surgical procedures in applications ranging from plastic and orthopedic surgery to tissue engineering and drug delivery.
This paper references
10.1097/00006534-199610000-00015
Injectable Cartilage Using Polyethylene Oxide Polymer Substrates
D. Sims (1996)
10.1007/s001050050399
Bemerkungen zur Eignung der Schweinehaut als biologisches Modell für die Haut des Menschen
W. Meyer (1996)
10.1002/047147875x
Principles of polymerization
G. Odian (1981)
10.1016/0032-3861(94)90129-5
Reaction behaviour and kinetic constants for photopolymerizations of multi(meth)acrylate monomers
K. Anseth (1994)
10.1016/0304-4165(86)90306-5
Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue.
R. Farndale (1986)
10.1016/0009-2509(94)E0055-U
Kinetic Gelation model predictions of crosslinked polymer network microstructure
K. Anseth (1994)
10.2307/1292758
Essentials of human anatomy
R. T. Woodburne (1969)
10.1073/PNAS.91.13.5967
Inhibition of thrombosis and intimal thickening by in situ photopolymerization of thin hydrogel barriers.
J. L. Hill-West (1994)
10.1111/j.1751-1097.1984.tb04622.x
TRANSMISSION OF HUMAN EPIDERMIS AND STRATUM CORNEUM AS A FUNCTION OF THICKNESS IN THE ULTRAVIOLET AND VISIBLE WAVELENGTHS
W. A. Bruls (1984)
10.1201/b18423
The Biomedical Engineering Handbook
J. Bronzino (1995)
10.1201/9780429285097
Hydrogels in Medicine and Pharmacy
N. Peppas (1987)
10.1111/j.1751-1097.1989.tb02908.x
MINIATURE PIG AS AN ANIMAL MODEL TO STUDY PHOTOAGING *
A. Fourtanier (1989)
10.1021/JS970159I
In vitro model(s) for the percutaneous delivery of active tissue repair agents.
M. Walker (1997)
10.1006/JSRE.1995.1236
Local release of fibrinolytic agents for adhesion prevention.
J. L. Hill-West (1995)



This paper is referenced by
10.1016/j.biomaterials.2012.04.050
A review of trends and limitations in hydrogel-rapid prototyping for tissue engineering.
T. Billiet (2012)
10.1016/J.MOLMED.2005.09.002
Mesenchymal stem cell therapy to rebuild cartilage.
D. Magne (2005)
10.1016/j.biomaterials.2011.05.044
Network connectivity, mechanical properties and cell adhesion for hyaluronic acid/PEG hydrogels.
S. Ouasti (2011)
10.1016/j.biomaterials.2013.05.060
Transdermal regulation of vascular network bioengineering using a photopolymerizable methacrylated gelatin hydrogel.
R. Lin (2013)
10.1021/cr200157d
Hydrogels for protein delivery.
T. Vermonden (2012)
Engineered Micro-Environments and Vibrational Culture Systems for Vocal Fold Tissue Engineering
J. Kutty (2008)
10.5607/en.2011.20.2.110
Simple and Novel Three Dimensional Neuronal Cell Culture Using a Micro Mesh Scaffold
S. J. Yoo (2011)
10.1201/B13733-25
Advances in Biomaterials for Clinical Orthopaedic Applications
Michele S Marcolongo (2012)
10.1007/978-90-481-8790-4_17
Injectable Hydrogels: From Basics to Nanotechnological Features and Potential Advances
B. Baroli (2010)
10.14314/POLIMERY.2015.435
Układy polimerowe formowane in situ do zastosowań biomedycznych. Cz. II. Wstrzykiwalne układy hydrożelowe
A. Korytkowska-Wałach (2015)
10.1186/s40634-019-0215-3
Translational applications of photopolymerizable hydrogels for cartilage repair
Weikun Meng (2019)
10.1016/j.carbpol.2015.07.101
Development of crosslinked methylcellulose hydrogels for soft tissue augmentation using an ammonium persulfate-ascorbic acid redox system.
Gittel T Gold (2015)
10.1038/nmat4157
Light-triggered in vivo Activation of Adhesive Peptides Regulates Cell Adhesion, Inflammation and Vascularization of Biomaterials
Ted T. Lee (2015)
10.1021/ACS.BIOMAC.6B01368
Synthesis and Characterization of Injectable Sulfonate-Containing Hydrogels.
Jue Liang (2016)
10.1002/JBM.A.30660
Influence of gel properties on neocartilage formation by auricular chondrocytes photoencapsulated in hyaluronic acid networks.
C. Chung (2006)
10.1016/S0142-9612(02)00582-3
Photoinitiated crosslinked degradable copolymer networks for tissue engineering applications.
K. A. Davis (2003)
10.1007/978-1-4614-4328-5_9
Exploring the Future of Hydrogels in Rapid Prototyping: A Review on Current Trends and Limitations
T. Billiet (2013)
10.1016/J.RADPHYSCHEM.2018.12.034
The influence of monomer/solvent feed ratio on POEGDMA thermoresponsive hydrogels: Radiation-induced synthesis, swelling properties and VPTT
E. Suljovrujic (2019)
10.1533/9780857097163.1.35
Polymeric biomaterials for tissue engineering
G. Wei (2014)
10.1002/jbm.b.33936
In vitro evaluation of a basic fibroblast growth factor-containing hydrogel toward vocal fold lamina propria scar treatment.
Josh Erndt-Marino (2018)
10.1016/j.dental.2017.11.020
Photopolymerization of cell-laden gelatin methacryloyl hydrogels using a dental curing light for regenerative dentistry.
Nelson Monteiro (2018)
10.1016/J.IJPHARM.2007.09.043
Screening poly(ethyleneglycol) micro- and nanogels for drug delivery purposes.
T. Van Thienen (2008)
Signaling from matrix elasticity and TGF-beta1 to cells of the cardiac valve
H. Wang (2013)
10.1002/jor.21114
Injectable gellan gum hydrogels with autologous cells for the treatment of rabbit articular cartilage defects
J. T. Oliveira (2010)
10.1089/TEN.2005.11.1852
Effects of dynamic fluid pressure on chondrocytes cultured in biodegradable poly(glycolic acid) fibrous scaffolds.
L. Lu (2005)
10.1023/B:ABME.0000007799.60142.78
Engineering Structurally Organized Cartilage and Bone Tissues
B. Sharma (2004)
10.1002/jbm.b.31053
Efficacy of titanium dioxide photocatalyst for inhibition of bacterial colonization on percutaneous implants.
Y. Oka (2008)
10.1016/J.IJADHADH.2013.02.016
Effect of viscoelasticity on the spherical and flat adhesion characteristics of photopolymerizable acrylate polymer networks
N. Lakhera (2013)
10.1007/s40005-019-00449-9
Long acting injectable formulations: the state of the arts and challenges of poly(lactic-co-glycolic acid) microsphere, hydrogel, organogel and liquid crystal
W. Lee (2019)
10.1039/C4TB01832J
Liposomal delivery of horseradish peroxidase for thermally triggered injectable hyaluronic acid-tyramine hydrogel scaffolds.
Cindy D. Ren (2015)
10.1089/TEN.2005.11.201
Bioresponsive phosphoester hydrogels for bone tissue engineering.
D. Wang (2005)
10.1002/AIC.690460702
Biomaterials: Status, challenges, and perspectives
R. Langer (2000)
See more
Semantic Scholar Logo Some data provided by SemanticScholar