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PAF1 Complex Component Leo1 Helps Recruit Drosophila Myc To Promoters

Jennifer M. Gerlach, M. Furrer, Maria Gallant, Dirk Birkel, Apoorva Baluapuri, E. Wolf, P. Gallant
Published 2017 · Biology, Medicine

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Significance We identify the PAF1 complex component Leo1 as a factor that helps recruit Myc to its target genes. In particular when Myc is overexpressed, Leo1 becomes limiting for transcriptional regulation by Myc. The Myc oncogene is a transcription factor with a powerful grip on cellular growth and proliferation. The physical interaction of Myc with the E-box DNA motif has been extensively characterized, but it is less clear whether this sequence-specific interaction is sufficient for Myc’s binding to its transcriptional targets. Here we identify the PAF1 complex, and specifically its component Leo1, as a factor that helps recruit Myc to target genes. Since the PAF1 complex is typically associated with active genes, this interaction with Leo1 contributes to Myc targeting to open promoters.
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