Online citations, reference lists, and bibliographies.

Differentially Expressed Protein Pdcd4 Inhibits Tumor Promoter-induced Neoplastic Transformation.

J. Cmarik, H. Min, G. Hegamyer, S. Zhan, M. Kulesz-Martin, H. Yoshinaga, S. Matsuhashi, N. Colburn
Published 1999 · Biology, Medicine
Cite This
Download PDF
Analyze on Scholarcy
An mRNA differential display comparison of mouse JB6 promotion-sensitive (P+) and -resistant (P-) cells identified a novel gene product that inhibits neoplastic transformation. The JB6 P+ and P- cells are genetic variants that differ in their transformation response to tumor promoters; P+ cells form anchorage-independent colonies that are tumorigenic, and P- cells do not. A differentially displayed fragment, A7-1, was preferentially expressed in P- cells at levels >/=10-fold those in P+ cells, making its mRNA a candidate inhibitor of neoplastic transformation. An A7-1 cDNA was isolated that was identical to murine Pdcd4 gene cDNAs, also known as MA-3 or TIS, and analogous to human H731 and 197/15a. Until now, the function of the Pdcd4 protein has been unknown. Paralleling the mRNA levels, Pdcd4 protein levels were greater in P- than in P+ cells. Pdcd4 mRNA was also expressed at greater levels in the less progressed keratinocytes of another mouse skin neoplastic progression series. To test the hypothesis that Pdcd4 inhibits tumor promoter-induced transformation, stable cell lines expressing antisense Pdcd4 were generated from parental P- cells. The reduction of Pdcd4 proteins in antisense lines was accompanied by acquisition of a transformation-sensitive (P+) phenotype. The antisense-transfected cells were reverted to their initial P- phenotype by overexpression of a Pdcd4 sense fragment. These observations demonstrate that the Pdcd4 protein inhibits neoplastic transformation.
This paper references

This paper is referenced by
Regulation of actin dynamics by protein kinase R control of gelsolin enforces basal innate immune defense.
Aaron T Irving (2012)
Splicing factor SRSF3 represses the translation of programmed cell death 4 mRNA by associating with the 5′-UTR region
Jong-Wook Kim (2014)
Pdcd4 protein and mRNA level alterations do not correlate in human lung tumors.
S. Kalinichenko (2008)
mTOR and Regulation of Translation
Yoshinori Tsukumo (2014)
Programmed cell death 4 ( PDCD 4 ) repression is involved with tumor cell differentiation and lymph node metastasis in patients with colon cancer
Kaitao Yuan (2016)
PDCD4 controls the G1/S-phase transition in a telomerase-immortalized epithelial cell line and affects the expression level and translation of multiple mRNAs
Astrid R. N. Haas (2020)
The action of Pdcd4 may be cell type specific: evidence that reduction of dUTPase levels might contribute to its tumor suppressor activity in Bon-1 cells
B. Lankat-Buttgereit (2007)
The inhibitory action of PDCD4 in lipopolysaccharide/D-galactosamine-induced acute liver injury
X. Wang (2013)
MiR-21 overexpression is associated with acquired resistance of EGFR-TKI in non-small cell lung cancer.
Bing Li (2014)
MicroRNA 744-3p promotes MMP-9-mediated metastasis by simultaneously suppressing PDCD4 and PTEN in laryngeal squamous cell carcinoma
John Zeng-Hong Li (2016)
The role of Pdcd4 in tumour suppression and protein translation.
Qing Wang (2018)
The role of AP-1, NF-κB and ROS/NOS in skin carcinogenesis: The JB6 model is predictive
Arindam Dhar (2004)
Identification of embryonic pancreatic genes using Xenopus DNA microarrays.
Tadayoshi Hayata (2009)
Enhanced Arginine Methylation of Programmed Cell Death 4 Protein during Nutrient Deprivation Promotes Tumor Cell Viability*
Marta M Fay (2014)
Hexavalent chromium induces malignant transformation of human lung bronchial epithelial cells via ROS-dependent activation of miR-21-PDCD4 signaling
Poyil Pratheeshkumar (2016)
Programmed Cell Death-4 Tumor Suppressor Protein Contributes to Retinoic Acid–Induced Terminal Granulocytic Differentiation of Human Myeloid Leukemia Cells
B. Ozpolat (2007)
PDCD4 inhibits the malignant phenotype of ovarian cancer cells.
Zeng-Tao Wei (2009)
Isocorydine Targets the Drug-Resistant Cellular Side Population through PDCD4-Related Apoptosis in Hepatocellular Carcinoma
Ping Lu (2012)
Clinical applications of molecular profiling in colorectal cancer: Review of the literature
Elrasheid A. H. Kheirelseid (2013)
MicroRNA-4262 activates the NF-κB and enhances the proliferation of hepatocellular carcinoma cells.
Sen Lu (2016)
Tumor suppressor PDCD4 inhibits NF-κB-dependent transcription in human glioblastoma cells by direct interaction with p65.
Soon-Kyung Hwang (2014)
Programmed cell death factor 4 enhances the chemosensitivity of colorectal cancer cells to Taxol.
Daqing Wang (2019)
Aberrant overexpression of microRNAs activate AKT signaling via down-regulation of tumor suppressors in natural killer-cell lymphoma/leukemia.
Yasuo Yamanaka (2009)
MicroRNAs in development and disease.
Danish Sayed (2011)
Viability Nutrient Deprivation Promotes Tumor Cell Programmed Cell Death 4 Protein during Enhanced Arginine Methylation of Molecular Bases of Disease
Matthew Powers (2014)
Targeting the eIF4A RNA helicase as an anti-neoplastic approach.
Jennifer Chu (2015)
Effects of Oncogenic Gαq and Gα11 Inhibition by FR900359 in Uveal Melanoma
D. Lapadula (2018)
The mechanisms and clinical significance of PDCD4 in colorectal cancer.
Jiali Long (2019)
Challenges and Opportunities of MicroRNAs in Lymphomas
Giacoma De Tullio (2014)
Expression of programmed cell death protein 4 in nonmelanoma skin cancer compared with psoriasis and normal skin, a preliminary study
Mona R. E. Abdel-Halim (2016)
Current Status and Perspectives Regarding LNA-Anti-miR Oligonucleotides and microRNA miR-21 Inhibitors as a Potential Therapeutic Option in Treatment of Colorectal Cancer.
Reza Nedaeinia (2017)
Clinical significance of programmed cell death 4 expression in malignant progression of human nasal inverted papillomas
Yan Min Wang (2012)
See more
Semantic Scholar Logo Some data provided by SemanticScholar