Online citations, reference lists, and bibliographies.
← Back to Search

Self-association Of The Death Domains Of The P55 Tumor Necrosis Factor (TNF) Receptor And Fas/APO1 Prompts Signaling For TNF And Fas/APO1 Effects (*)

M. Boldin, I. Mett, E. Varfolomeev, I. Chumakov, Y. Shemer-Avni, J. Camonis, D. Wallach
Published 1995 · Biology, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Signaling by the p55 tumor necrosis factor (TNF) receptor and by the structurally related receptor Fas/APO1 is initiated by receptor clustering. Data presented here and in other recent studies (Wallach, D., Boldin, M., Varfolomeev, E. E., Bigda, Y., Camonis, H. J. and Mett, I.(1994) Cytokine 6, 556; Song, H. Y., Dunbar, J. D., and Bonner, D. B.(1994) J. Biol. Chem. 269, 22492-22495) indicate that part of that region within the intracellular domains of the two receptors that is involved in signaling for cell death, as well as for some other effects (the “death domain”, specifically self-associates. We demonstrate also the expected functional consequence of this association; a mere increase in p55 TNF receptor expression, or the expression just of its intracellular domain, is shown to trigger signaling for cytotoxicity as well as for interleukin 8 gene induction, while expression of the intracellular domain of Fas/APO1 potentiates the cytotoxicity of co-expressed p55 TNF receptor. These findings indicate that the p55 TNF and Fas/APO1 receptors play active roles in their own clustering and suggest the existence of cellular mechanisms that restrict the self-association of these receptors, thus preventing constitutive signaling.
This paper references
A receptor for tumor necrosis factor defines an unusual family of cellular and viral proteins.
C. Smith (1990)
The cDNA structure, expression, and chromosomal assignment of the mouse Fas antigen.
R. Watanabe-Fukunaga (1992)
Induction of apoptosis by monoclonal antibody anti-APO-1 class switch variants is dependent on cross-linking of APO-1 cell surface antigens.
J. Dhein (1992)
A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor
S. Yonehara (1989)
Preparations of lymphotoxin induce resistance to their own cytotoxic effect.
D. Wallach (1984)
The structure of tumor necrosis factor-alpha at 2.6 A resolution. Implications for receptor binding.
M. Eck (1989)
Yeast promoters and lacZ fusions designed to study expression of cloned genes in yeast.
L. Guarente (1983)
Molecular cloning of a human monocyte-derived neutrophil chemotactic factor (MDNCF) and the induction of MDNCF mRNA by interleukin 1 and tumor necrosis factor
K. Matsushima (1988)
The p70 tumor necrosis factor receptor mediates cytotoxicity
Renu A. Holler (1992)
A novel protein domain required for apoptosis. Mutational analysis of human Fas antigen.
N. Itoh (1993)
Increased serum levels of soluble receptors for tumor necrosis factor in cancer patients.
D. Aderka (1991)
Dual role of the p75 tumor necrosis factor (TNF) receptor in TNF cytotoxicity
J. Bigda (1994)
Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.
M. Gossen (1992)
Elimination of false positives that arise in using the two-hybrid system.
P. Bartel (1993)
Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences
J. Downward (1984)
Cytoplasmic truncation of the p55 tumour necrosis factor (TNF) receptor abolishes signalling, but not induced shedding of the receptor.
C. Brakebusch (1992)
Molecular cloning and expression of the type 1 and type 2 murine receptors for tumor necrosis factor.
R. Goodwin (1991)
A novel domain within the 55 kd TNF receptor signals cell death
L. A. Tartaglia (1993)
A B‐lymphocyte activation molecule related to the nerve growth factor receptor and induced by cytokines in carcinomas.
I. Stamenković (1989)
The two-hybrid system: an assay for protein-protein interactions.
S. Fields (1994)
Monoclonal antibody-mediated tumor regression by induction of apoptosis.
B. Trauth (1989)
Molecular cloning and expression of the human 55 kd tumor necrosis factor receptor
H. Loetscher (1990)
Structure of tumour necrosis factor
E. Jones (1989)
Down regulation of the receptors for tumor necrosis factor by interleukin 1 and 4 beta-phorbol-12-myristate-13-acetate.
H. Holtmann (1987)
Screening for proteins that bind to the intracellular domains of the two tumor necrosis factor receptors (TNF-R) revealed effective self-association of the p55 TNF-R “death domain”, which can trigger signaling
D. Wallach (1994)
Solubilization and purification of enzymatically active glutathione S-transferase (pGEX) fusion proteins.
J. V. Frangioni (1993)
Molecular cloning and expression of the fas ligand, a novel member of the tumor necrosis factor family
T. Suda (1993)
Aggregation of the intracellular domain of the type 1 tumor necrosis factor receptor defined by the two-hybrid system.
H. Y. Song (1994)
Analysis of mammalian fibroblast transformation by normal and mutated human EGF receptors.
J. D. Haley (1989)
A novel genetic system to detect protein–protein interactions
S. Fields (1989)
Antibodies to a soluble form of a tumor necrosis factor (TNF) receptor have TNF-like activity.
H. Engelmann (1990)

This paper is referenced by
An MMP-2/MMP-9 inhibitor, 5a, enhances apoptosis induced by ligands of the TNF receptor superfamily in cancer cells
O. Nyormoi (2003)
The p75 Neurotrophin Receptor Activates Akt (Protein Kinase B) through a Phosphatidylinositol 3-Kinase-dependent Pathway*
Philippe P Roux (2001)
Radioiodine refractory differentiated thyroid cancer.
Yuchen Jin (2018)
VB-111 for cancer
P. Triozzi (2011)
Serum elevations of soluble Fas (CD95/Apo-I) concur in deregulating T cell apoptosis during active lupus disease
F. Silvestris (2002)
Enhanced Fas-associated death domain recruitment by histone deacetylase inhibitors is critical for the sensitization of chronic lymphocytic leukemia cells to TRAIL-induced apoptosis
S. Inoue (2009)
FADD, a novel death domain-containing protein, interacts with the death domain of fas and initiates apoptosis
A. Chinnaiyan (1995)
Apoptosis in oncology
Xiao Qiang Fan (2001)
Involvement of Two NF-κB Binding Elements in Tumor Necrosis Factor α-, CD40-, and Epstein-Barr Virus Latent Membrane Protein 1-mediated Induction of the Cellular Inhibitor of Apoptosis Protein 2 Gene*
S. Hong (2000)
the Type 1 TNF Receptor Induction of Jak/STAT Signaling by Activation of
D. Donner (2013)
Structures of the extracellular domain of the type I tumor necrosis factor receptor.
J. Naismith (1996)
Mutational analysis and NMR studies of the death domain of the tumor necrosis factor receptor-1.
J. Telliez (2000)
Herpes Simplex Virus Blocks Fas-Mediated Apoptosis Independent of Viral Activation of NF-κB in Human Epithelial HEp-2 Cells
E. R. Morton (2007)
Self‐Assembled RANK Induces Osteoclastogenesis Ligand‐Independently
K. Kanazawa (2005)
Acid sphingomyelinase-derived ceramide signaling in apoptosis.
E. Gulbins (2002)
The p75 neurotrophin receptor and neuronal apoptosis
G. Barrett (2000)
The intracellular 52-kd Ro/SSA autoantigen in keratinocytes is up-regulated by tumor necrosis factor alpha via tumor necrosis factor receptor I.
V. Gerl (2005)
Serine/Threonine Kinase Activity Associated with the Cytoplasmic Domain of the Lymphotoxin-β Receptor in HepG2 Cells*
M. Wu (1997)
Targeting of the Myc pathway as a novel approach for cancer therapy
H. Mo (2006)
The multilevel regulation of CD95 signaling outcome.
M. Yurchenko (2012)
FasL Binds Preassembled Fas
P. Golstein (2000)
Mature T lymphocyte apoptosis--immune regulation in a dynamic and unpredictable antigenic environment.
M. Lenardo (1999)
Leptin and apoptosis inhibitor soluble fas antigen in the serum of patients with osteosarcoma and neuroectodermal bone tumors
N. Kushlinskii (2006)
Two tumour necrosis factor receptors: structure and function.
P. Vandenabeele (1995)
Evidence for a function of death-receptor-related, death-domain-containing proteins in anoikis
S. Frisch (1999)
CHAPTER 2 FasL-Independent Activation of Fas
F. Mollinedo (2007)
The Met-196 → Arg Variation of Human Tumor Necrosis Factor Receptor 2 (TNFR2) Affects TNF-α-induced Apoptosis by Impaired NF-κB Signaling and Target Gene Expression*
A. Till (2005)
A mathematical model of caspase function in apoptosis
M. Fussenegger (2000)
Apoptosis in AIDS.
A. Badley (1997)
Molecular Mechanisms Controlling Susceptibitliy to Tumor Necrosis Factor Induced Cell Death
J. Klefström (1996)
Expression of apoptosis‐associated genes by human dermal scar fibroblasts
D. Messadi (1999)
LARD: a new lymphoid-specific death domain containing receptor regulated by alternative pre-mRNA splicing.
G. Screaton (1997)
See more
Semantic Scholar Logo Some data provided by SemanticScholar