Online citations, reference lists, and bibliographies.
← Back to Search

An Insulin-response Element-binding Protein That Ameliorates Hyperglycemia In Diabetes*

B. C. Villafuerte, E. Kaytor
Published 2005 · Medicine, Biology

Cite This
Download PDF
Analyze on Scholarcy
Share
Insulin modulates glucose homeostasis, but the role of insulin-responsive transcription factors in such actions is not well understood. Recently, we have identified the insulin-response element-binding protein-1 (IRE-BP1) as a transcription factor that appears to mediate insulin action on multiple target genes. To examine the possibility that IRE-BP1 is an insulin-responsive glucoregulatory factor involved in the metabolic actions of insulin, we investigated the effect of adenoviral overexpression of hepatic IRE-BP1 on the glycemic control of insulin-resistant diabetic rats. Adenoviral IRE-BP1 lowered both fasting and postprandial glucose levels, and microarray of hepatic RNA revealed modulation of the expression of genes involved in gluconeogenesis, lipogenesis, and fatty acid oxidation. The insulin mimetic effects of IRE-BP1 were also confirmed in L6 myocytes; stable constitutive expressions of IRE-BP1 enhanced glucose transporter expression, glucose uptake, and glycogen accumulation in these cells. These findings showed physiologic sufficiency of IRE-BP1 as the transcriptional mediator of the metabolic action of insulin. Understanding IRE-BP1 action should constitute a useful probe into the mechanisms of metabolic regulation and an important target to develop therapeutic agents that mimic or enhance insulin action.
This paper references
10.1042/BST0301076
Gene regulation of mammalian desaturases.
M. Nakamura (2002)
10.1016/S0898-6568(98)00003-5
Combined effects of insulin and dexamethasone on cyclic AMP phosphodiesterase 3 and glycogen metabolism in cultured rat hepatocytes.
T. Hermsdorf (1998)
10.1016/S0092-8674(00)80709-6
Deconstructing Type 2 Diabetes
S. Taylor (1999)
10.1002/dmrr.340
The changing world demography of type 2 diabetes
A. Green (2003)
10.1007/s001099900050
Forkhead transcription factors: new insights into protein kinase B (c-akt) signaling
G. Kops (1999)
10.1006/MCPR.2002.0405
A method for the rapid construction of cRNA standard curves in quantitative real-time reverse transcription polymerase chain reaction.
S. Fronhoffs (2002)
10.1073/pnas.0730870100
Regulation of hepatic fasting response by PPARγ coactivator-1α (PGC-1): Requirement for hepatocyte nuclear factor 4α in gluconeogenesis
J. Rhee (2003)
10.2337/diab.40.7.837
Nutrition and Somatomedin: XXV. Regulation of Insulinlike Growth Factor Binding Protein 1 in Primary Cultures of Normal Rat Hepatocytes
B. C. Villafuerte (1991)
10.1016/S0006-291X(02)03027-9
Adiponutrin mRNA expression in white adipose tissue is rapidly induced by meal-feeding a high-sucrose diet.
D. Polson (2003)
10.1042/BST0290310
Regulation of liver carnitine palmitoyltransferase I gene expression by hormones and fatty acids.
J. F. Louet (2001)
10.1038/414799a
Insulin signalling and the regulation of glucose and lipid metabolism
A. Saltiel (2001)
10.1301/NR.2003.DEC.397-412
Evaluation of insulin sensitivity in clinical practice and in research settings.
Lais U Monzillo (2003)
10.1016/S1521-690X(03)00041-1
Metabolic and genetic influence on glucose metabolism in type 2 diabetic subjects--experiences from relatives and twin studies.
H. Beck-Nielsen (2003)
10.1042/BJ3430505
The malonyl-CoA-long-chain acyl-CoA axis in the maintenance of mammalian cell function.
V. Zammit (1999)
10.1007/s00109-002-0384-9
Lipoprotein lipase: structure, function, regulation, and role in disease
J. R. Mead (2002)
10.1016/S1043-2760(02)00662-8
Role of Akt/protein kinase B in metabolism
E. L. Whiteman (2002)
10.1074/JBC.M404349200
Insulin-response Element-binding Protein 1
B. C. Villafuerte (2004)
10.1002/dmrr.260
The role of increased liver triglyceride content: a culprit of diabetic hyperglycaemia?
S. Song (2002)
10.1016/S0891-5849(97)00069-5
Reactive oxygen species activate glucose transport in L6 myotubes.
N. Kozlovsky (1997)
10.1055/S-2001-15114
Triglycerides, fatty acids and insulin resistance--hyperinsulinemia.
E. Kraegen (2001)
10.1074/jbc.274.1.305
Dual Roles for Glucokinase in Glucose Homeostasis as Determined by Liver and Pancreatic β Cell-specific Gene Knock-outs Using Cre Recombinase*
C. Postic (1999)
10.1016/S0070-2137(96)80003-3
Type III cyclic nucleotide phosphodiesterases and insulin action.
V. Manganiello (1996)
10.1006/MCPR.1996.0059
Competitive reverse transcription/polymerase chain reaction for the quantification of p53 and mdm2 mRNA expression.
G. Totzke (1996)
10.1093/ILAR.32.3.16
Zucker Diabetic Fatty Rat as a Model for Non-insulin-dependent Diabetes Mellitus
R. Peterson (1990)
10.1152/AJPCELL.1982.243.5.C278
Hormonal stimulation of myoblast differentiation in the absence of DNA synthesis.
K. Turo (1982)
10.1074/JBC.M209643200
The Differentiation of Skeletal Muscle Cells Involves a Protein-tyrosine Phosphatase-α-mediated C-Src Signaling Pathway*
H. Lu (2002)
10.1038/286904A0
Insulin triggers cyclic AMP-dependent activation and phosphorylation of a plasma membrane cyclic AMP phosphodiesterase
R. J. Marchmont (1980)
10.1074/jbc.M211136200
Maturation of the Regulation of GLUT4 Activity by p38 MAPK during L6 Cell Myogenesis*
Wenyan Niu (2003)
10.1172/JCI116681
Mechanism by which hyperglycemia inhibits hepatic glucose production in conscious rats. Implications for the pathophysiology of fasting hyperglycemia in diabetes.
L. Rossetti (1993)
10.1097/00075197-200209000-00014
Interaction between free fatty acids and glucose metabolism
G. Boden (2002)
10.1038/nature01667
Insulin-regulated hepatic gluconeogenesis through FOXO1–PGC-1α interaction
P. Puigserver (2003)
10.1074/JBC.M105193200
Adiponutrin, a Transmembrane Protein Corresponding to a Novel Dietary- and Obesity-linked mRNA Specifically Expressed in the Adipose Lineage*
S. Baulande (2001)
Cellular and molecular mechanisms of non-insulin dependent diabetes mellitus.
Y. Kruszynska (1996)
10.1152/PHYSREV.1996.76.4.1109
Regulation of gene expression by insulin.
R. O'Brien (1991)
10.3109/10520299209110039
Calibration of quantitative histochemical methods: estimation of glycogen content of muscle fibers using the PAS reaction.
W. J. van der Laarse (1992)
10.1128/MCB.19.6.4008
Protein Kinase B/Akt Participates in GLUT4 Translocation by Insulin in L6 Myoblasts
Q. Wang (1999)
10.1016/S0167-0115(01)00228-2
Hormone-specific combinations of isoforms of adenylyl cyclase and phosphodiesterase in the rat liver
K. Yamatani (2001)
10.1007/S11892-003-0066-1
Fat-induced liver insulin resistance
P. Shah (2003)
10.1042/BJ20020430
New perspectives in the regulation of hepatic glycolytic and lipogenic genes by insulin and glucose: a role for the transcription factor sterol regulatory element binding protein-1c.
F. Foufelle (2002)



This paper is referenced by
Changes of serum trace elements in patients with type 2 diabetes mellitus
Guilan Zhang (2019)
10.1101/2020.07.27.223107
Computational and experimental characterization of the novel ECM glycoprotein SNED1 and prediction of its interactome
Sylvain D. Vallet (2020)
10.1089/thy.2014.0169
A thyroid hormone challenge in hypothyroid rats identifies T3 regulated genes in the hypothalamus and in models with altered energy balance and glucose homeostasis.
A. Herwig (2014)
10.1007/s12072-007-9025-2
Genome-wide transcriptome expression in the liver of a mouse model of high carbohydrate diet-induced liver steatosis and its significance for the disease
I. Deaciuc (2008)
10.1089/zeb.2014.0995
The involvement of cholesterol in sepsis and tolerance to lipopolysaccharide highlighted by the transcriptome analysis of zebrafish (Danio rerio).
S. Dios (2014)
10.1074/jbc.M511223200
Insulin Dynamically Regulates Calmodulin Gene Expression by Sequential O-Glycosylation and Phosphorylation of Sp1 and Its Subcellular Compartmentalization in Liver Cells*
G. Majumdar (2006)
10.1210/en.2008-1294
Transgenic expression of insulin-response element binding protein-1 in beta-cells reproduces type 2 diabetes.
B. C. Villafuerte (2009)
Sex-different control of hepatic metabolism in relation to insulin sensitivity
Carolina Gustavsson (2010)
10.1210/en.2007-1693
Regulation of insulin-response element binding protein-1 in obesity and diabetes: potential role in impaired insulin-induced gene transcription.
Jaspreet K. Chahal (2008)
10.1038/s41598-017-13099-4
DNA-Methylation and Body Composition in Preschool Children: Epigenome-Wide-Analysis in the European Childhood Obesity Project (CHOP)-Study
P. Rzehak (2017)
Semantic Scholar Logo Some data provided by SemanticScholar