Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

Elemental Analysis Mirrors Epidermal Differentiation.

B. Forslind, Y. Werner-Linde, M. Lindberg, J. Pallon
Published 1999 · Biology, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
Using a scanning nuclear microprobe, the distribution of elements and trace elements of skin cross sections of normal skin, non-lesional psoriatic skin and in dry atopic skin have been mapped. In non-lesional psoriatic skin and in dry atopic skin the epidermal Ca-gradient is higher than that of normal skin. In addition, abnormally high Fe and Zn levels were recorded in the stratum granulosum and corneum regions in the pathological skin. It is suggested that these findings correlate to an increased cell turnover in the basal cell layer of the psoriatic and atopic skins. The ratio of Ca/Zn in stratum corneum of paralesional psoriatic skin is approximately 8:1 compared to 12: 1 in normal skin and 15: 1 in atopic skin. This suggests that the differentiation process in paralesional psoriatic skin may actually be an example of disturbed programmed cell death.
This paper references
10.1111/j.1365-2133.1993.tb00138.x
Structural relationship between epidermal lipid lamellae, lamellar bodies and desmosomes in human epidermis: an ultrastructural study
M. Fartasch (1993)
10.1111/1523-1747.EP12462576
Electron probe analysis of human skin: element concentration profiles.
R. R. Warner (1988)
10.1093/CARCIN/11.5.847
Determination of the length of the histological stages of apoptosis in normal liver and in altered hepatic foci of rats.
W. Bursch (1990)
10.1002/AJA.1001990303
Apoptosis in human skin development: Morphogenesis, periderm, and stem cells
R. Polakowska (1994)
10.1111/1523-1747.EP12606037
Corneocytes undergo systematic changes in element concentrations across the human inner stratum corneum.
R. R. Warner (1995)
Calcium induced modulation of lipid synthesis in cultured human epidermal keratinocytes
M Ponec (1985)
10.1016/0168-583X(93)95557-L
Applications in medicine using the new Lund microprobe
Jan Pallon (1993)
10.1111/1523-1747.EP12478519
Programmed cell death in terminally differentiating keratinocytes: role of endogenous endonuclease.
C. McCall (1991)
10.1016/B978-012371020-8/50014-7
X-ray microanalysis of the integument
B. Forslind (1999)
10.1111/1523-1747.EP12394858
Expression of Fas antigen on keratinocytes in vivo and induction of apoptosis in cultured keratinocytes.
K. Sayama (1994)
10.1111/1523-1747.EP12472355
Apoptotic index: discriminant feature for the differentiation of cutaneous diffuse malignant follicular center cell lymphomas from lymphoid hyperplasia.
C. Miracco (1993)
10.1007/s004030050231
Stratum corneum swelling. Biophysical and computer assisted quantitative assessments
L. Norlén (1997)
Diagnostic features of atopic dermatitis
J. Hanifin (1980)
10.1038/nbt0594-487
Apoptosis and Its Role in Human Disease
P. J. Barr (1994)
Apoptosis: molecular mechanisms in programmed cell death.
L. Fesus (1991)
Elemental analysis on freeze-dried sections of human skin: studies by electron microprobe and particle induced X-ray emission analysis.
B. Forslind (1984)
10.1016/0014-5793(89)80210-8
Apoptotic hepatocytes become insoluble in detergents and chaotropic agents as a result of transglutaminase action
L. Fesus (1989)
10.1111/1523-1747.EP12363594
Cell death by apoptosis in epidermal biology.
A. Haake (1993)



This paper is referenced by
10.1016/j.apradiso.2013.02.019
Characterization of the depth distribution of Ca, Fe and Zn in skin samples, using synchrotron micro-x-ray fluorescence (SμXRF) to help quantify in-vivo measurements of elements in the skin.
E. Desouza (2013)
10.1080/09687680210132476
Desmosomal adhesion: structural basis, molecular mechanism and regulation (Review)
D. Garrod (2002)
10.1111/j.1600-0625.2007.00692.x
Skin surface electric potential as an indicator of skin condition: a new, non‐invasive method to evaluate epidermal condition
Eriko Kawai (2008)
10.1152/japplphysiol.00924.2007
Sweat electrolyte concentrations obtained from within occlusive coverings are falsely high because sweat itself leaches skin electrolytes.
L. Weschler (2008)
10.1556/AMICR.49.2002.1.13
Hyperproliferation of normally quiescent keratinocytes in non-lesional psoriatic skin due to high calcium concentration (an organotypic culture model).
Anna Kenderessy Szabó (2002)
Atopic dermatitis : Aspects of defence defects
Lena Hagströmer (2009)
10.1159/000458417
Total Calcium and Albumin Are Decreased in the Deeper Epidermis of Patients with Chronic Kidney Disease-Associated Pruritus
Akishi Momose (2017)
10.1016/j.jtbi.2016.02.032
Mathematical model for calcium-assisted epidermal homeostasis.
Yasuaki Kobayashi (2016)
10.1038/jid.2009.119
Functional expression of heme oxygenase-1 in human differentiated epidermis and its regulation by cytokines.
Ikuko Numata (2009)
10.4172/2155-9554.1000246
Irritant Contact Dermatitis: Mechanisms to Repair
Cheryl Lee D Eberting (2014)
10.1007/s00441-009-0848-0
Mechanical-stimulation-evoked calcium waves in proliferating and differentiated human keratinocytes
M. Tsutsumi (2009)
Foreign molecules in biomembranes
Quoc Dat Pham (2016)
10.1046/J.1523-1747.2001.01262.X
Attenuated total reflection-Fourier transform infrared spectroscopy as a possible method to investigate biophysical parameters of stratum corneum in vivo.
L. Brancaleon (2001)
10.1111/j.1600-0625.2011.01298.x
Skin surface electrical potential as an indicator of skin condition: observation of surfactant‐induced dry skin and middle‐aged skin
Eriko Kawai (2011)
10.1002/9781444345384.CH27
The Skin Barrier in Atopic Dermatitis
S. Danby (2011)
10.1038/SJ.JID.5700127
Stratum-specific expression of human transferrin receptor increases iron in mouse epidermis.
L. Milstone (2006)
Friction and discomfort in the design and use of hand tools : exposure to textures at different loads and velocities with reference to contamination
O. Bobjer (2004)
10.1111/j.1600-0846.2009.00420.x
Mathematical analysis of intercellular calcium propagation induced by adenosine triphosphate
M. Tsutsumi (2010)
10.1007/978-94-007-0265-3_44
Roles of transient receptor potential proteins (TRPs) in epidermal keratinocytes.
M. Denda (2011)
10.15230/SCSK.2011.37.3.283
Skin Brightening Effect of Gel Essence Containing High Concentrated-Marine Minerals in Silicon Copolyol Network Film in vivo
S. Kim (2011)
10.1016/S0749-0690(03)00037-5
The aged epidermal permeability barrier: basis for functional abnormalities.
P. Elias (2002)
10.1111/exd.12302
Frontiers in epidermal barrier homeostasis – an approach to mathematical modelling of epidermal calcium dynamics
M. Denda (2014)
10.1111/j.1365-2230.2005.02054.x
Biophysical assessment of atopic dermatitis skin and effects of a moisturizer
L. Hagströmer (2006)
10.1046/J.1523-1747.2003.12367.X
Influx of calcium and chloride ions into epidermal keratinocytes regulates exocytosis of epidermal lamellar bodies and skin permeability barrier homeostasis.
M. Denda (2003)
10.1111/j.1365-2133.2008.08860.x
Function of oleic acid on epidermal barrier and calcium influx into keratinocytes is associated with N‐methyl d‐aspartate‐type glutamate receptors
Y. Katsuta (2009)
Skin hydration-How water and osmolytes influence biophysical properties of stratum
corneum (2013)
10.1080/000155500750042862
The skin barrier: analysis of physiologically important elements and trace elements.
B. Forslind (2000)
10.1016/j.jdermsci.2012.04.003
Impact of epidermal desquamation on tissue stores of iron.
L. Milstone (2012)
10.1046/J.0022-202X.2001.01500.X
Negative electric potential induces alteration of ion gradient and lamellar body secretion in the epidermis, and accelerates skin barrier recovery after barrier disruption.
M. Denda (2002)
10.1007/3-540-32953-6_7
Permeability and Antioxidant Barriers in Aged Epidermis
J. Thiele (2006)
10.1016/J.CLINDERMATOL.2019.04.009
Aging of the skin barrier.
E. Choi (2019)
10.1016/S0738-081X(02)00373-5
The skin barrier and use of moisturizers in atopic dermatitis.
M. Lodén (2003)
See more
Semantic Scholar Logo Some data provided by SemanticScholar