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A Humic Acid-polyquaternium-10 Stoichiometric Self-assembled Fibrilla Polyelectrolyte Complex: Effect Of PH On Synthesis, Characterization, And Drug Release

M. Siyawamwaya, Y. Choonara, P. Kumar, P. P. D. Kondiah, L. D. du Toit, V. Pillay
Published 2016 · Materials Science

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ABSTRACT A polyelectrolyte complex (PEC) was produced and validated from humic acid and polyquaternium-10 using a solution-blend method. Humic acid was used based on its properties of encapsulating hydrophilic and hydrophobic drugs while polyquaternium-10 provided high swellability in aqueous media. PECs at varying pH values were prepared and characterized for their physicochemical properties. Efavirenz (model drug) was used to assess the performance of the PEC. Results revealed that drug-loading ranged between 11.9–23.91% and PEC formation was due to ionic reactions between the amino (polyquaternium-10) and carboxylic (humic acid) groups. This formed a fibrilla PEC complex that provided controlled release of efavirenz. GRAPHICAL ABSTRACT
This paper references
10.1016/j.ejpb.2013.03.010
Mechanistic basis for unexpected bioavailability enhancement of polyelectrolyte complexes incorporating BCS class III drugs and carrageenans.
C. Heinen (2013)
10.1208/s12249-013-9945-1
Design of an Interpolyelectrolyte Gastroretentive Matrix for the Site-Specific Zero-Order Delivery of Levodopa in Parkinson’s Disease
N. Ngwuluka (2013)
10.3390/ijms14059906
Cationic Antimicrobial Polymers and Their Assemblies
A. M. Carmona-Ribeiro (2013)
10.1016/J.EJPS.2005.01.016
Chitosan-reinforced alginate microspheres obtained through the emulsification/internal gelation technique.
A. Ribeiro (2005)
10.1021/SC500634P
Recent Advances in Graft Copolymerization and Applications of Chitosan: A Review
V. Thakur (2014)
10.1002/JPS.10522
Increased physical stability and improved dissolution properties of itraconazole, a class II drug, by solid dispersions that combine fast- and slow-dissolving polymers.
K. Six (2004)
10.3103/S014768741004006X
The elemental composition and amphiphilic properties of humic acids in southern taiga soils
A. V. Bahvalov (2010)
10.2495/DNE-V4-N1-32-46
ANALYTICAL STUDY OF HUMIC ACID FROM VARIOUS SOURCES COMMONLY USED AS FERTILIZER: EMPHASIS ON HEAVY METAL CONTENT
N. N. Rupiasih (2009)
10.1016/j.carbpol.2014.08.077
Chitosan-hyaluronic acid polyelectrolyte complex scaffold crosslinked with genipin for immobilization and controlled release of BMP-2.
S. D. Nath (2015)
10.1208/s12249-010-9576-8
A Composite Polyelectrolytic Matrix for Controlled Oral Drug Delivery
P. Bawa (2010)
10.1016/J.COLSURFA.2004.10.019
Solubility and dissociation of lignitic humic acids in water suspension
M. Klučáková (2005)
10.1128/AAC.48.9.3483-3490.2004
Efavirenz Therapy in Rhesus Macaques Infected with a Chimera of Simian Immunodeficiency Virus Containing Reverse Transcriptase from Human Immunodeficiency Virus Type 1
M. J. Hofman (2004)
10.1021/ACSSUSCHEMENG.5B01327
Synthesis and Applications of Biodegradable Soy Based Graft Copolymers: A Review
M. Thakur (2016)
10.1016/J.AJPS.2014.08.002
Evaluation of chitosan–anionic polymers based tablets for extended-release of highly water-soluble drugs
Y. Shao (2015)
Pekař, M. Colloids Surf
M. Klučáková (2005)
10.1016/J.COLSURFB.2005.06.010
pH-sensitive polyelectrolyte complex gel microspheres composed of chitosan/sodium tripolyphosphate/dextran sulfate: swelling kinetics and drug delivery properties.
Wen-Ching Lin (2005)
10.1016/S0168-3659(02)00410-8
Cationic cellulose hydrogels: kinetics of the cross-linking process and characterization as pH-/ion-sensitive drug delivery systems.
R. Rodríguez (2003)
10.1016/J.POLYMER.2015.04.086
Self-healing polymer nanocomposite materials: A review
V. Thakur (2015)
10.1016/S0045-6535(97)00026-X
Binding of organic pollutants to humic and fulvic acids: Influence of pH and the structure of humic material
F. D. Paolis (1997)
10.1016/j.carbpol.2013.10.008
Chitosan/pectin/gum Arabic polyelectrolyte complex: process-dependent appearance, microstructure analysis and its application.
Ruei-Yi Tsai (2014)
10.1002/MACP.1984.020061984120
A new class of complex water‐soluble polyelectrolytes
V. Kabanov (1984)
10.1021/jf8035353
Complementary multianalytical approach to study the distinctive structural features of the main humic fractions in solution: gray humic acid, brown humic acid, and fulvic acid.
R. Baigorri (2009)
10.1016/j.colsurfb.2010.11.022
Interaction of cellulose-based cationic polyelectrolytes with mucin.
E. Mažonienė (2011)
10.1016/j.ejps.2008.09.004
Chitosan/pectin polyelectrolyte complexes: selection of suitable preparative conditions for colon-specific delivery of vancomycin.
F. Bigucci (2008)
10.1016/j.rinphs.2011.06.001
Comparative evaluation of humic substances in oral drug delivery.
Mohd. Aamir Mirza (2011)
10.1016/j.ijbiomac.2013.08.035
Carboxymethyl gum kondagogu-chitosan polyelectrolyte complex nanoparticles: preparation and characterization.
A. Kumar (2013)
10.1016/j.jcis.2010.07.027
Using jet mixing to prepare polyelectrolyte complexes: complex properties and their interaction with silicon oxide surfaces.
Caroline Ankerfors (2010)
10.1016/J.COLSURFA.2005.07.022
Evaluation of amphiphilic properties of fulvic acid and humic acid by alkylpyridinium binding study
Min Min Yee (2006)
10.1016/S0939-6411(03)00034-1
Influence of cationic cellulose structure on its interactions with sodium dodecylsulfate: implications on the properties of the aqueous dispersions and hydrogels.
R. Rodríguez (2003)
10.1016/J.EURPOLYMJ.2013.10.018
Cationic cellulose and its interaction with chondroitin sulfate. Rheological properties of the polyelectrolyte complex
K. Bierbrauer (2014)
10.1080/00914037.2015.1038816
A Review: Overview of Novel Polyelectrolyte Complexes as Prospective Drug Bioavailability Enhancers
M. Siyawamwaya (2015)
10.3103/S014768740803006X
Separation and characterization of amphiphilic humic acid fractions
A. A. Stepanov (2008)
10.1016/S0016-7037(02)01044-X
Proton-binding study of standard and reference fulvic acids, humic acids, and natural organic matter
J. Ritchie (2003)
10.1016/j.jyp.2013.11.002
Chitosan-pectin polyelectrolyte complex as a carrier for colon targeted drug delivery.
Sonia Pandey (2013)
10.1051/AGRO:2003054
Elemental analysis, FTIR and 13C-NMR of humic acids from sewage sludge composting
S. Amir (2004)
10.1080/10934520701781160
Ecotoxicities of polyquaterniums and their associated polyelectrolyte-surfactant aggregates (PSA) to Gambusia holbrooki
J. Cumming (2008)
10.14227/DT190412P21
Effect of Formulation Variables on Dissolution of Water-Soluble Drug from Polyelectrolyte Complex Beads
M. Saleem (2012)
10.1016/J.JCLEPRO.2014.11.031
Review of sewage sludge management: standards, regulations and analytical methods.
B. Cieślik (2015)
10.1016/S1773-2247(13)50024-4
Development and characterization of taste masked Efavirenz pellets utilizing hot melt extrusion
Abhilasha Singh (2013)
10.1208/pt0804097
Preparation and evaluation of chitosan/carrageenan beads for controlled release of sodium diclofenac
Pimwipha Piyakulawat (2008)
10.1016/J.IJBIOMAC.2014.09.044
Recent advances in green hydrogels from lignin: a review.
V. Thakur (2015)
10.1016/j.apsb.2013.11.001
Fundamental aspects of solid dispersion technology for poorly soluble drugs
Y. Huang (2014)
10.1016/S0939-6411(03)00153-X
Comparative studies on polyelectrolyte complexes and mixtures of chitosan-alginate and chitosan-carrageenan as prolonged diltiazem clorhydrate release systems.
Cristián Tapia (2004)
10.1016/J.POLYMDEGRADSTAB.2008.10.017
Characterization and biodegradation of chitosan-alginate polyelectrolyte complexes
X. Li (2009)



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