Online citations, reference lists, and bibliographies.
← Back to Search

Immunomodulatory And Cellular Anti-oxidant Activities Of Caffeic, Ferulic, And P-coumaric Phenolic Acids: A Structure–activity Relationship Study

Soumaya Kilani-Jaziri, Imèn Mokdad-Bzéouich, M. Krifa, Nouha Nasr, K. Ghédira, L. Chekir‐Ghedira
Published 2017 · Biology, Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
Abstract Many studies have been performed to assess the potential utility of natural products as immunomodulatory agents to enhance host responses and to reduce damage to the human body. To determine whether phenolic compounds (caffeic, ferulic, and p-coumaric acids) have immunomodulatory effects and clarify which types of immune effector cells are stimulated in vitro, we evaluated their effect on splenocyte proliferation and lysosomal enzyme activity. We also investigated the activity of natural killer (NK) cells and cytotoxic T lymphocytes (CTL). In addition, induction of the cellular antioxidant activity in splenocytes, macrophages, and red blood cells was determined by measuring the fluorescence of the DCF product. The study first results indicated that caffeic, ferulic, and p-coumaric acids significantly promote LPS-stimulated splenocyte proliferation, suggesting a potential activation of B cells, and enhanced humoral immune response in hosts treated by the tested natural products. Phenolic acids significantly enhanced the killing activity of isolated NK and CTL cells but had negligible effects on mitogen-induced proliferation of splenic T cells. We showed that caffeic acid enhances lysosomal enzyme activity in murine peritoneal macrophages, suggesting a potential role in activating such cells. Immunomodulatory activity was concomitant with the cellular antioxidant effect in macrophages and splenocytes of caffeic and ferulic acids. We conclude from this study that caffeic, ferulic, and p-coumaric acids exhibited an immunomodulatory effect which could be ascribed, in part, to their cytoprotective effect via their antioxidant capacity. Furthermore, these results suggest that these natural products could be potentially used to modulate immune cell functions in physiological and pathological conditions.
This paper references
10.1021/JF011348W
Antioxidant properties of ferulic acid and its related compounds.
H. Kikuzaki (2002)
10.1016/J.EJPHAR.2005.03.012
Gentisic acid, an aspirin metabolite, inhibits oxidation of low-density lipoprotein and the formation of cholesterol ester hydroperoxides in human plasma.
K. Ashidate (2005)
10.1016/j.jfda.2014.07.010
Antioxidant activities and contents of flavonoids and phenolic acids of Talinum triangulare extracts and their immunomodulatory effects.
Dung Y Liao (2015)
10.1038/nri2115
Life and death in peripheral T cells
P. Krammer (2007)
10.1039/B416101G
Antioxidant activity of olive phenols: mechanistic investigation and characterization of oxidation products by mass spectrometry.
M. Roche (2005)
10.1021/JF0715166
Cellular antioxidant activity (CAA) assay for assessing antioxidants, foods, and dietary supplements.
Kelly L. Wolfe (2007)
10.1038/ni795
Signaling via LTβR on the lamina propria stromal cells of the gut is required for IgA production
H. Kang (2002)
10.1016/J.INTIMP.2006.04.002
Anti-tumor and immunomodulating effects of Pleurotus ostreatus mycelia-derived proteoglycans.
Itisam Sarangi (2006)
10.1371/journal.pone.0140242
A 1H NMR Investigation of the Interaction between Phenolic Acids Found in Mango (Manguifera indica cv Ataulfo) and Papaya (Carica papaya cv Maradol) and 1,1-diphenyl-2-picrylhydrazyl (DPPH) Free Radicals
L. M. López-Martínez (2015)
10.1016/j.taap.2009.06.013
Signal-transducing mechanisms of ketamine-caused inhibition of interleukin-1 beta gene expression in lipopolysaccharide-stimulated murine macrophage-like Raw 264.7 cells.
Ta-liang Chen (2009)
10.1080/01480545.2016.1190740
Use of in vitro assays to assess the potential cytotoxic, genotoxic and antigenotoxic effects of vanillic and cinnamic acid
G. Taner (2017)
10.1038/nri1200
Macrophage migration inhibitory factor: a regulator of innate immunity
T. Calandra (2003)
10.1016/S0955-2863(01)00215-7
Ferulic acid antioxidant protection against hydroxyl and peroxyl radical oxidation in synaptosomal and neuronal cell culture systems in vitro: structure-activity studies.
Jaroslaw Kanski (2002)
Ferulic acid anti-oxidant protection against hydroxyl and peroxyl radical oxidation in synaptosomal and neuronal cell culture systems in vitro: structure-activity studies
J Kanski (2002)
10.3390/MOLECULES19010078
Screening of the LTBP2 gene in a north Indian population with primary congenital glaucoma
K. Mohanty (2013)
10.3109/01480545.2014.908297
Limoniastrum guyonianum methanol extract induces immunomodulatory and anti-inflammatory effects by activating cellular anti-oxidant activity
M. Krifa (2015)
10.1016/J.TIV.2003.12.012
Prooxidant property of green tea polyphenols epicatechin and epigallocatechin-3-gallate: implications for anticancer properties.
S. Azam (2004)
10.1021/jf304076z
Antioxidant activity of phenolic acids and their metabolites: synthesis and antioxidant properties of the sulfate derivatives of ferulic and caffeic acids and of the acyl glucuronide of ferulic acid.
A. Piazzon (2012)
10.1016/S0378-8741(03)00278-2
Immunomodulatory activities of Clausena excavata Burm. f. wood extracts.
A. Manosroi (2003)
10.4172/2155-9899.S13-006
Natural Killer cells in Innate Defense against Infective Pathogens
Dongfang Wang (2013)
10.1016/0022-1759(83)90303-4
Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays.
T. Mosmann (1983)
10.1016/J.FOODCHEM.2010.09.065
The cellular antioxidant activity in red blood cells (CAA-RBC): A new approach to bioavailability and synergy of phytochemicals and botanical extracts
Manuela Blasa (2011)
10.1016/S0162-3109(98)00026-5
Characteristic immunostimulation by angelan isolated from Angelica gigas Nakai.
S. Han (1998)
10.4172/2161-0444.1000365
Anti-Inflammatory Effects of p-coumaric Acid in LPS-StimulatedRAW264.7 Cells: Involvement of NF-úB and MAPKs Pathways
Y. Zhao (2016)
10.3109/08923973.2010.504926
Leaf extracts from Phlomis crinita Cav. subs. mauritanica Munby affect immune cell functions in vitro
Ilef Limem (2011)
10.1055/S-2006-957992
Inhibitory effects of Oriental herbal medicines on IL-8 induction in lipopolysaccharide-activated rat macrophages.
G. Lee (1995)
10.1016/0891-5849(92)90184-I
Antioxidant potential of ferulic acid.
E. Graf (1992)
10.1371/journal.pone.0036025
The Effect of Enzymatically Polymerised Polyphenols on CD4 Binding and Cytokine Production in Murine Splenocytes
Daisuke Yamanaka (2012)
10.1021/JF026182T
Phenolic acids in foods: an overview of analytical methodology.
R. Robbins (2003)
10.18632/oncotarget.6812
Chicoric acid binds to two sites and decreases the activity of the YopH bacterial virulence factor
Alicja Kuban-Jankowska (2016)
10.1039/C5RA01911G
Gallic acid: a versatile antioxidant with promising therapeutic and industrial applications
Bharti Badhani (2015)
Litomosoides carinii in rodents: immunomodulation in potentiating action of diethylcarbamazine.
R. Chatterjee (1988)
10.1021/jf901072t
Antioxidant activity of phenolic acids in lipid oxidation catalyzed by different prooxidants.
Věra Kristinová (2009)
10.1016/J.FOODCHEM.2007.07.005
Immunomodulatory activities of common vegetables and spices of Umbelliferae and its related coumarins and flavonoids
Jaw-Ming Cherng (2008)
10.1016/J.JEP.2005.03.031
In vitro immunomodulatory effect of Pouteria cambodiana (Pierre ex Dubard) Baehni extract.
A. Manosroi (2005)
10.1016/J.TOXLET.2013.05.241
P10-16Use of in vitro assays to assess the potential cytotoxic, genotoxic and antigenotoxic effects of vanillic acid
G. Taner (2013)
10.3390/molecules19010078
Structure and Antioxidant Activity of Polyphenols Derived from Propolis
A. Kurek-Górecka (2013)
10.1016/j.fct.2013.04.025
Antimicrobial and demelanizing activity of Ganoderma lucidum extract, p-hydroxybenzoic and cinnamic acids and their synthetic acetylated glucuronide methyl esters.
S. Heleno (2013)
FREE RADICALS AND CARES FOR AGING PETS
I. Ivanov (2008)
10.1186/s12986-016-0080-3
Hydroxycinnamic acid derivatives: a potential class of natural compounds for the management of lipid metabolism and obesity
M. Alam (2016)



This paper is referenced by
10.1111/jfbc.13116
Chemical characterization and immunostimulatory activity of phenolic acid bound arabinoxylans derived from foxtail and barnyard millets.
Aswini Srinivasan (2019)
10.1016/J.BCAB.2018.07.004
Biorefining of wheat bran for the purification of ferulic acid
N. Gopalan (2018)
10.1007/978-981-13-1745-3_24-1
Coumaric and Cinnamic Acids in Food
N. P. Ulrih (2020)
10.1016/j.foodchem.2020.126716
Comparative study on the bioactive components and in vitro biological activities of three green seedlings.
X. Li (2020)
10.1016/j.jddst.2018.04.019
Layer-by-layer Polyelectrolytes Coating of Alginate Microgels for Sustained Release of Sodium Benzoate and Zosteric Acid.
Q. Wang (2018)
10.1002/jssc.201601445
High-throughput ultra high performance liquid chromatography combined with mass spectrometry approach for the rapid analysis and characterization of multiple constituents of the fruit of Acanthopanax senticosus (Rupr. et Maxim.) Harms.
Y. Han (2017)
10.3390/biom10081096
The Interaction of Bovine β-Lactoglobulin with Caffeic Acid: From Binding Mechanisms to Functional Complexes
N. Stănciuc (2020)
10.3390/scipharm86020011
Acetylcholinesterase Inhibition and Antioxidant Activity of N-trans-Caffeoyldopamine and N-trans-Feruloyldopamine
Muamer Dizdar (2018)
10.1016/j.phrs.2019.104538
Caffeic acid reduces A53T α-synuclein by activating JNK/Bcl-2-mediated autophagy in vitro and improves behaviour and protects dopaminergic neurons in a mouse model of Parkinson's disease.
Y. Zhang (2019)
10.1080/10286020.2019.1680643
The first synthesis and immunomodulatory properties of p-hydroxyphenyl caffeate derived from Wedelia trilobata
Ji-Su Yang (2020)
10.1159/000492253
Synergistic Anticancer Activity of Combined Use of Caffeic Acid with Paclitaxel Enhances Apoptosis of Non-Small-Cell Lung Cancer H1299 Cells in Vivo and in Vitro
J. Min (2018)
10.3389/fonc.2019.00541
Chemical and Pharmacological Aspects of Caffeic Acid and Its Activity in Hepatocarcinoma
Kaio Murilo Monteiro Espíndola (2019)
10.1111/ANU.13087
Effects of ferulic acid on growth performance, immunity and antioxidant status in genetically improved farmed tilapia (Oreochromis niloticus) fed oxidized fish oil
Lijuan Yu (2020)
Immunomodulatory and anti-inflammatory activities of the defatted alcoholic extract and mucilage of Hibiscus sabdariffa L. leaves, and their chemical characterization
M. Hussein (2019)
10.1007/s11033-019-04658-1
Antiproliferative and apoptotic effects of caffeic acid on SK-Mel-28 human melanoma cancer cells
L. P. Pelinson (2019)
10.1093/jas/sky278
Tea polyphenols protect bovine mammary epithelial cells from hydrogen peroxide-induced oxidative damage in vitro.
Y. Ma (2018)
10.5372/1905-7415.1103.552
The effect of p-coumaric acid and ellagic acid on the liver and lungs in a rat model of sepsis
Aykut Urfalıoğlu (2017)
10.1024/0300-9831/a000526
Powders with small microparticle size from Hedera helix and Scrophularia nodosa exhibited high preventive antioxidant activity against H2O2-induced oxidative stress in mouse primary spleen cells.
N. Soualeh (2018)
10.1186/s12906-018-2156-2
Inhibition of lipopolysaccharide (LPS)-induced neuroinflammatory response by polysaccharide fractions of Khaya grandifoliola (C.D.C.) stem bark, Cryptolepis sanguinolenta (Lindl.) Schltr and Cymbopogon citratus Stapf leaves in raw 264.7 macrophages and U87 glioblastoma cells
Francine Kengne Mediesse (2018)
10.1111/1750-3841.15163
Pectin and inulin stimulated the mucus formation at a similar level: An omics-based comparative analysis.
Jinli Xie (2020)
Semantic Scholar Logo Some data provided by SemanticScholar