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Sustained Release Properties Of Alginate Microspheres And Tabletted Microspheres Of Diclofenac Sodium
Published 2000 · Materials Science, Medicine
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This study focused on the properties of diclofenac sodium (DNa) alginate (alg) microspheres and tabletted DNa alg microspheres using different polymers as additives. DNa alginate microspheres were prepared by the emulsification method and different polymers such as Eudragit (Eud) NE 30 D, Eudragit (Eud) RS 30 D and Aquacoat, which were incorporated into alg gel to control the release rate of drug. The release properties of DNa alg microspheres (1:1) were affected by the size, drug load of microspheres and also by the incorporated polymers, pH and ionic strength of dissolution medium. Tabletting of alg microspheres using carrageenan (carr), alg, pectin, NaCMC, tragacanth (trgh) and HPMC as additives in a (50:50) ratio produced tablets with good physical properties and also better controlled release of DNa. Dissolution studies were carried out in pH7.2 phosphate buffer and phosphate buffers whose pH values were gradually changed from pH 3 to 7.4. The rank order of DNa release from tablets was carr
This paper references
Calcium alginate matrices for oral multiple unit administration. I: Pilot investigations of production method
T. Østberg (1992)
Preparation and tabletting of dipyridamole alginate-Eudragit microspheres.
A. Gürsoy (1998)
Effect of aqueous polymer dispersions on properties of diclofenac/alginate beads and in vivo evaluation in rats
M. Türkoğlu (1997)
Evaluation of tabletted microspheres of dipyridamole
A Gu È Rsoy (1995)
Chitosan/calcium alginate microcapsules for intestinal delivery of nitrofurantoin.
P. Hari (1996)
In‐vitro and In‐vivo Studies of the Diclofenac Sodium Controlled‐release Matrix Tablets
C. Liu (1995)
Calcium alginate matrices for oral multiple unit administration: IV. Release characteristics in different media
Tone Østberg (1994)
Examination of natural gums as matrices for sustained release of theophylline.
M. Nakano (1984)
Effect of interpolymer complex formation of chitosan with pectin or acacia on the release behaviour of chlorpromazine HCl
M. Meshali (1993)
Release characteristics of diclofenac sodium from encapsulated natural gum mini-matrix formulations
J. Sujja-areevath (1996)
Structure and behaviour in hydrophilic matrix sustained release dosage forms: 3. The influence of pH on the sustained-release performance and internal gel structure of sodium alginate matrices
A. C. Hodsdon (1995)
On the employment of λ-carrageenan in a matrix system. I. Sensitivity to dissolution medium and comparison with Na carboxymethylcellulose and xanthan gum
M. C. Bonferoni (1993)
Microencapsulation of drugs with aqueous colloidal polymer dispersions.
R. Bodmeier (1993)
Solvent and plasticizer influences on ethylcellulose-microcapsules.
M. E. Palomo (1996)
Polymers for sustained release formulations of dipyridamole-alginate microspheres and tabletted microspheres.
A. Gürsoy (1999)
Calcium alginate matrices for oral multiple unit administration. III: Influence of calcium concentration, amount of drug added and alginate characteristics on drug release
Tone Østberg (1994)
Evaluation of Tableted Microspheres of Dipyridamole
A. Gürsoy (1995)
Calcium alginate matrices for oral
T. é STBERG (1994)
Chitosan microspheres of diclofenac sodium, II: In vitro and in vivo evaluation.
M. Açikgöz (1995)
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Carrageenans in Solid Dosage Form Design
K. Picker-Freyer (2008)
Statistically Designed Spheronization and Scale-Up of Ibuprofen Microparticulates Using the Rotor Disk Fluid-Bed Technology: Coating for Prolonged Release and Hard Gelatin Encapsulation of Microparticulates
B. Chukwumezie (2003)
Polymer relationships during preparation of chitosan-alginate and poly-l-lysine-alginate nanospheres.
S. De (2003)
Polyelectrolyte biomaterial interactions provide nanoparticulate carrier for oral insulin delivery.
C. Reis (2008)
Stomach-site specific drug delivery system of clarithromycin for eradication of Helicobacter pylori.
P. Rajinikanth (2009)
Alginate/hydrophobic HPMC (60M) particulate systems: new matrix for site-specific and controlled drug delivery
K. Ghosal (2011)
Polysaccharides derived from tragacanth as biocompatible polymers and Gels
A. Fattahi (2013)
PREPARATION AND IN-VITRO EVALUATION OF SODIUM ALGINATE MICROSPHERES CONTAINING DIPHTHERIA TOXOID AS NEW VACCINE DELIVERY
A. Mokaram (2008)
Controlled Delivery of Drugs from Alginate Matrix
Anu Shilpa (2003)
Design and Optimization of PLGA-Based Diclofenac Loaded Nanoparticles
D. L. Cooper (2014)
Microcapsule-embedded hydrogel patches for ultrasound responsive and enhanced transdermal delivery of diclofenac sodium.
Da Huang (2019)
Poly (D,L-lactide-co-glycolide) microspheres for long-term intravitreal delivery of aciclovir: influence of fatty and non-fatty additives.
C. Martínez-Sancho (2003)
Evaluation of sodium diclofenac release using natural rubber latex as carrier
Patricia Businaro Aielo (2014)
Preparation and characterization of alginate–carrageenan complex films
Y. H. Roh (2006)
FORMULATION AND EVALUATION OF GLIPIZIDE MICROCAPSULES PREPARED BY NATURAL GUMS AND SYNTHETIC POLYMERS
J VaidyaMehul (2014)
Multivariate analysis for the optimization of polysaccharide-based nanoparticles prepared by self-assembly.
Sara Pistone (2016)
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I. El-Mahdi (2016)
FORMULATION AND EVALUATION OF MUCOADHESIVE MICROCAPSULES OF METFORMIN HCL WITH GUM KARAYA
Rajiv Jash (2011)
Formulation and bioavailability of controlled release salbutamol sulphate tablets using natural additives.
A. Nouh (2010)
Microencapsulation: an acclaimed novel drug-delivery system for NSAIDs in arthritis.
K. M. Manjanna (2010)
Preparation of Microbeads by different Techniques and Study of their influence on Evaluation Parameters
U. D. Shivhare (2013)
Insulin encapsulation in reinforced alginate microspheres prepared by internal gelation.
Catarina M. Silva (2006)
- Marine Materials in Drug Delivery and Tissue Engineering: From Natural Role Models to Bone Regeneration and Repair and Slow Delivery of Therapeutic Drugs, Proteins, and Genes
Besim Ben-Nissan (2013)
In vitro and in vivo studies of ibuprofen-loaded biodegradable alginate beads
B. Arıca (2005)
An Investigation into Formulation and Therapeutic Effectiveness of Nanoparticle Drug Delivery for Select Pharmaceutical Agents
D. L. Cooper (2016)
Preparation and release characteristics of polymer-coated and blended alginate microspheres.
D. Lee (2003)
Sodium Alginate-Based Microspheres of Salbutamol Sulphate for Nasal Administration: Formulation and Evaluation
R. M. Farid (2012)
Polysaccharides from Seaweeds: Modification and Potential Application in Drug Delivery
H. Prado (2013)
Preparation and characterization of ibuprofen-loaded alginate microspheres using ethylenediamine as a crosslinker
Sabyasachi Maiti (2008)
Development of pH-sensitive tamarind seed polysaccharide-alginate composite beads for controlled diclofenac sodium delivery using response surface methodology.
A. Nayak (2011)
Alginate-konjac glucomannan-chitosan beads as controlled release matrix.
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