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The Nation-wide Swedish Family-cancer Database--updated Structure And Familial Rates.

K. Hemminki, X. Li, K. Plná, C. Granström, P. Vaittinen
Published 2001 · Medicine

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The Swedish Family-Cancer Database was expanded to include all Swedes born in 1932 and later (offspring) with their parents, totaling 10.2 million individuals. Cancer cases were retrieved from the Swedish Cancer Registry from the years 1958 to 1998, including over 1 million primary cancers and in situ tumors. Some 10%, of offspring diagnosed with cancer lack any parental information. Incidence rates of cancers were similar in the database and in the Cancer Registry to age 70, but at higher ages the rates in the Database were lower, probably because of selection. The familial risk for all types of cancer in offspring was 1.73 when a parent had the same type of cancer. The familial rates were increased for all main cancer sites, except for the upper aerodigestive tract, stomach, liver, pancreas and bone marrow (leukemia). The rates were 7.47 for thyroid, 4.69 for testis, and over 2.00 for melanoma, ovary, prostate, skin, endocrine glands and endometrium.
This paper references
10.1056/NEJM199512143332403
[Cancer in the parents of children with cancer].
J. Olsen (1997)
10.1056/NEJM199805073381902
Risk of cancer among offspring of childhood-cancer survivors. Association of the Nordic Cancer Registries and the Nordic Society of Paediatric Haematology and Oncology.
R. Sankila (1998)
10.1002/1098-2272(200102)20:2<247::AID-GEPI7>3.0.CO;2-U
Cancer risks to spouses and offspring in the family‐cancer database
K. Hemminki (2001)
10.1093/JNCI/86.21.1600
Systematic population-based assessment of cancer risk in first-degree relatives of cancer probands.
D. Goldgar (1994)
10.1093/OXFORDJOURNALS.BMB.A072908
The inherited component of cancer.
D. Easton (1994)
10.1002/(SICI)1097-0215(19981005)78:2<172::AID-IJC9>3.0.CO;2-W
Age‐specific familial risks in common cancers of the offspring
K. Hemminki (1998)
10.1002/1098-2272(200101)20:1<107::AID-GEPI9>3.0.CO;2-4
Estimation of genetic and environmental components in colorectal and lung cancer and melanoma
K. Hemminki (2001)
10.1054/bjoc.2000.1585
Sibling risks in cancer: clues to recessive or X-linked genes?
K. Hemminki (2001)
10.1016/S0027-5107(00)00162-7
Genetic epidemiology of multistage carcinogenesis.
K. Hemminki (2001)
Hereditary cancer in adults.
H. Lynch (1995)
10.1056/NEJM200007133430201
Environmental and heritable factors in the causation of cancer--analyses of cohorts of twins from Sweden, Denmark, and Finland.
P. Lichtenstein (2000)
10.1002/(SICI)1097-0215(19961115)68:4<428::AID-IJC5>3.0.CO;2-2
Familial aggregation of colorectal cancer in the general population
B. Carstensen (1996)
10.1093/JNCI/89.4.287
Cancer in twins: genetic and nongenetic familial risk factors.
A. Ahlbom (1997)
10.1097/00001648-199911000-00016
Parental age and risk of sporadic and familial cancer in offspring: implications for germ cell mutagenesis.
K. Hemminki (1999)
Human Genetics: Problems and Approaches
F. Vogel (1979)
10.1016/S0092-8674(00)81683-9
The Hallmarks of Cancer
D. Hanahan (2000)
10.1093/JNCI/93.4.323
Re: High frequency of multiple melanomas and breast and pancreas carcinomas in CDKN2A mutation-positive melanoma families.
K. Plná (2001)
10.1002/(SICI)1097-0215(19960126)65:3<284::AID-IJC2>3.0.CO;2-W
Cancer mortality in relatives of women with ovarian cancer: The OPCS study
D. Easton (1996)
10.1080/028418601750288145
Genetic Epidemiology--science and ethics on familial cancers.
K. Hemminki (2001)
10.1054/bjoc.2001.1811
Birth order, family size, and the risk of cancer in young and middle-aged adults
K. Hemminki (2001)
10.1002/1097-0215(200102)9999:9999<::AID-IJC1147>3.0.CO;2-C
Modification of cancer risks in offspring by sibling and parental cancers from 2,112,616 nuclear families
C. Dong (2001)



This paper is referenced by
10.1097/01.CMR.0000198453.11580.7B
Familial risks for eye melanoma and retinoblastoma: results from the Swedish Family-Cancer Database
K. Hemminki (2006)
10.1111/j.1365-2141.2009.07874.x
Associated cancers in parents and offspring of polycythaemia vera and myelofibrosis patients
K. Hemminki (2009)
10.1007/s00125-009-1427-3
Familial association between type 1 diabetes and other autoimmune and related diseases
K. Hemminki (2009)
10.1038/sj.bjc.6600113
A case–control study of childhood leukaemia and paternal occupational contact level in rural Sweden
L. Kinlen (2002)
10.1002/ijc.24147
Long‐term risk of cardiovascular disease in Hodgkin lymphoma survivors—Retrospective cohort analyses and a concept for prospective intervention
A. Andersson (2009)
10.1371/journal.pone.0027130
An Epidemiological Reappraisal of the Familial Aggregation of Prostate Cancer: A Meta-Analysis
Michał Kiciński (2011)
10.1200/JCO.2007.14.6571
Survival patterns among lymphoma patients with a family history of lymphoma.
L. Anderson (2008)
10.1093/ANNONC/MDM413
Influence of education level on cancer survival in Sweden.
S. Hussain (2008)
Risk of NextMelanoma in PatientsWith Familial and SporadicMelanoma by Number of PreviousMelanomas
T. Chen (2015)
10.1093/IJE/DYL177
Parental age and risk of childhood cancers: a population-based cohort study from Sweden.
B. Yip (2006)
10.1093/JNCI/DJJ361
Autoimmunity and susceptibility to Hodgkin lymphoma: a population-based case-control study in Scandinavia.
O. Landgren (2006)
10.1093/jnci/djn146
Timing of familial breast cancer in sisters.
P. Rebora (2008)
10.1002/ijc.21387
Parental lung cancer as predictor of cancer risks in offspring: Clues about multiple routes of harmful influence?
K. Hemminki (2006)
10.1007/s10549-007-9692-7
Survival in breast cancer is familial
K. Hemminki (2007)
10.1111/J.1523-1755.2004.00650.X
Age-specific familial risks for renal cell carcinoma with evidence on recessive heritable effects.
K. Hemminki (2004)
10.1038/NG1002-233
Risk for familial breast cancer increases with age
K. Hemminki (2002)
Level of education and the risk of cancer in Sweden.
K. Hemminki (2003)
10.1002/cncr.10322
Familial and second gastric carcinomas
K. Hemminki (2002)
10.1002/ijc.22226
Heritable and environmental components in cervical tumors
E. Couto (2006)
10.1186/s40557-018-0259-3
Thyroid cancer among female workers in Korea, 2007–2015
Seonghoon Kang (2018)
10.3389/fneur.2015.00040
Concurrence of Multiple Sclerosis and Brain Tumors
D. Plantone (2015)
10.1016/j.eururo.2011.05.031
Familial renal cell carcinoma from the Swedish Family-Cancer Database.
H. Liu (2011)
10.1016/S1368-8375(02)00091-X
Familial upper aerodigestive tract cancers: incidence trends, familial clustering and subsequent cancers.
X. Li (2003)
Attributable risks of familial cancer from the Family-Cancer Database.
K. Hemminki (2002)
10.1016/j.canep.2012.05.009
Educational inequalities in cancer incidence and mortality in Lithuania: a record linkage study.
G. Smailytė (2012)
10.1677/ERC-09-0284
Histology-specific risks in testicular cancer in immigrants to Sweden.
K. Hemminki (2010)
10.1097/01.jom.0000199511.14305.dc
Socioeconomic and Occupational Risk Factors for Pancreatic Cancer:: A Cohort Study In Sweden
J. Ji (2006)
Lifestyle and Cancer
K. Hemminki (2003)
10.1038/sj.bjc.6604244
Family history of cancer as a risk factor for second malignancies after Hodgkin's lymphoma
A. Andersson (2008)
10.1002/ijc.20436
Inherited predisposition to early onset lung cancer according to histological type
X. Li (2004)
10.1097/01.CEJ.0000220633.93104.64
Lifestyle and cancer: effect of parental divorce
K. Hemminki (2006)
10.1067/j.cpsurg.2007.12.010
Recent advances in thyroid cancer.
Elizabeth G. Grubbs (2008)
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