Online citations, reference lists, and bibliographies.
← Back to Search

Cardiovascular And Growth Outcomes Of C57Bl/6J Mice Offspring Exposed To Maternal Stress And Ionizing Radiation During Pregnancy

S. Sreetharan, L. Stoa, M. Cybulski, D. E. Jones, Abigail H Lee, Adomas V Kulesza, S. Tharmalingam, D. Boreham, T. Tai, J. Wilson
Published 2019 · Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
Abstract Purpose: Developmental programming involves an adverse intrauterine environment which can result in offspring phenotype changes following birth. The developmental programming of hypertension has been reported to possibly involve oxidative stress at the cellular level. Ionizing radiation produces oxidative stress, even at low doses, and irradiation of animals is often coupled with potential sources of maternal stress such as transportation of animals or repeated handling. Materials and methods: Pregnant C57Bl/6J mice were irradiated on gestational day 15 with 5–1000 mGy 137Cs gamma radiation. Post-natal weight, blood pressure (BP) and heart rate (HR) were measured. Radiation had minimal effects at doses ≤300 mGy, but 1000 mGy caused a significant reduction in HR in male pups and growth reduction at 16 weeks of age in both genders. The sham-irradiation protocol included repeated transportation in order to acclimate animals to transport. However, it may have resulted in programming, as sham-irradiation alone resulted in elevated BP measures compared to the offspring of animals that were never transported. Results and conclusions: Overall, there were minimal effects on cardiovascular measures or offspring weight due to irradiation except at 1000 mGy. The presence of maternal stress, a known trigger of developmental programming, may have confounded any potential irradiation effects.
This paper references
Impact of oxidative stress in fetal
LP 1651025–1030. Thompson (2012)
10.1016/S0378-3782(02)00075-0
Prenatal maternal stress: effects on pregnancy and the (unborn) child.
E. Mulder (2002)
10.1016/j.bbr.2004.05.018
Correlations between behaviours in the elevated plus-maze and sensitivity to unpredictable subchronic mild stress: evidence from inbred strains of mice
C. Ducottet (2005)
Oxidative stress, radiation-adaptive
Y. 27119–127. Miura (2004)
Testosterone contributes to marked elevations
BT Alexander (2006)
Prenatal maternal stress: effects
JK Buitelaar (2002)
10.1667/RR14657.1
Ionizing Radiation Exposure During Pregnancy: Effects on Postnatal Development and Life
S. Sreetharan (2017)
10.1016/j.brainresrev.2007.11.004
Epigenetic programming of the stress response in male and female rats by prenatal restraint stress
M. Darnaudéry (2008)
10.1038/ajh.2008.301
Validation of volume-pressure recording tail-cuff blood pressure measurements.
Minjie Feng (2008)
Low birth weight and high birth weight infants are both at an increased risk to have type 2 diabetes among school children in Taiwan
J N Wei (2003)
10.1111/j.1651-2227.1999.tb00024.x
Prenatal exposure to ionizing radiation: sources, effects and regulatory aspects
P. Fattibene (1999)
10.1016/j.neuroscience.2009.11.023
Stress hormone synthesis in mouse hypothalamus and adrenal gland triggered by restraint is dependent on pituitary adenylate cyclase-activating polypeptide signaling
N. Stroth (2010)
10.1371/journal.pone.0156952
In-Utero Low-Dose Irradiation Leads to Persistent Alterations in the Mouse Heart Proteome
Mayur V. Bakshi (2016)
10.1016/J.MEHY.2005.08.020
Tracing the origins of "fetal origins" of adult diseases: programming by oxidative stress?
Z. Luo (2006)
10.1053/PLAC.2002.0819
Recent Insights into the pathogenesis of pre-eclampsia.
J. Roberts (2002)
10.1258/la.2009.009032
Environmental disturbance confounds prenatal glucocorticoid programming experiments in Wistar rats
D. O'regan (2010)
10.1136/bmj.302.6768.113-a
Fetal and infant origins of adult disease.
P. Bradley (1991)
10.3892/IJMM.2.5.607
Intrauterine events and the programming of adulthood disease: the role of fetal glucocorticoid exposure (Review).
M. Nyirenda (1998)
10.1097/00005344-200210000-00002
Enhanced Oxidative Stress As a Potential Mechanism Underlying the Programming of Hypertension In Utero
M. Franco (2002)
Prenatal glucocorticoid exposure programs adrenal
T. Tai (2015)
10.1155/2012/582748
Impact of Oxidative Stress in Fetal Programming
L. Thompson (2012)
10.1016/j.nlm.2008.07.001
Habituation to repeated stress: Get used to it
N. Grissom (2009)
10.1016/S0303-7207(01)00633-5
Glucocorticoid programming of the fetus; adult phenotypes and molecular mechanisms
J. Seckl (2001)
10.1038/bjc.1979.88
Radiobiology for the Radiologist
J. Hendry (1979)
Radiat Res. 45:357–372
J aging (2014)
10.1161/01.HYP.0000036455.62159.7E
Programming Effects of Short Prenatal Exposure to Dexamethasone in Sheep
M. Dodic (2002)
10.1016/0300-9629(96)00018-7
Intrauterine programming of hypertension in the rat: nutrient interactions.
S. Langley-Evans (1996)
10.1016/j.pneurobio.2012.05.010
Fetal stress and programming of hypoxic/ischemic-sensitive phenotype in the neonatal brain: Mechanisms and possible interventions
Y. Li (2012)
10.1073/pnas.2235592100
Cancer risks attributable to low doses of ionizing radiation: Assessing what we really know
D. Brenner (2003)
10.2307/3570971
The effects of prenatal radiation on postnatal development in rats.
R. L. Murphree (1960)
10.1016/j.genm.2008.03.012
Sex differences in the fetal programming of hypertension.
D. Grigore (2008)
Stress measurements in mice
JA Smith (1995)
10.1093/IJE/31.6.1235
Fetal origins of adult disease: strength of effects and biological basis.
D. Barker (2002)
10.1007/978-1-60761-247-6_3
Non-invasive blood pressure measurement in mice.
Minjie Feng (2009)
10.1136/bmj.301.6761.1111
The fetal and infant origins of adult disease.
D. Barker (1990)
10.1152/AJPREGU.00311.2006
Testosterone contributes to marked elevations in mean arterial pressure in adult male intrauterine growth restricted offspring.
N. Ojeda (2007)
10.1258/002367795780740249
Stress measurements in mice after transportation
J. S. Tuli (1995)
10.1093/ajh/hpw088
Adverse Effect of High-Fat Diet on Metabolic Programming in Offspring Born to a Murine Model of Maternal Hypertension.
M. Longo (2016)
10.1016/S0149-7634(03)00014-9
Prenatal stress and long-term consequences: implications of glucocorticoid hormones
S. Maccari (2003)
10.1530/REP-10-0077
Impact of maternal obesity on offspring obesity and cardiometabolic disease risk.
A. Drake (2010)
10.2337/DIACARE.26.2.343
Low birth weight and high birth weight infants are both at an increased risk to have type 2 diabetes among schoolchildren in taiwan.
J. Wei (2003)
10.1269/JRR.45.357
Oxidative stress, radiation-adaptive responses, and aging.
Y. Miura (2004)
10.1530/JOE-15-0244
Prenatal glucocorticoid exposure programs adrenal PNMT expression and adult hypertension.
P. Nguyen (2015)
10.1136/fn.81.1.F71
Low birthweight and adult insulin resistance: the “catch-up growth” hypothesis
S. Cianfarani (1999)
Prenatal stress and long-term consequences
O. Van Reeth (2003)
10.1038/nrendo.2014.73
Glucocorticoids and fetal programming part 1: outcomes
Vasilis G. Moisiadis (2014)
Low birth weight and high birth weight infants
LM Chuang (2003)
Intrauterine events and the programming
MJ 117–127.Nyirenda (1998)
10.1007/BF00400248
Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis
C. N. Hales (2004)
10.1259/BJR/63353075
Evidence for beneficial low level radiation effects and radiation hormesis.
L. Feinendegen (2005)



This paper is referenced by
Semantic Scholar Logo Some data provided by SemanticScholar