A Patient-specific Finite Element Methodology To Predict Damage Accumulation In Vertebral Bodies Under Axial Compression, Sagittal Flexion And Combined Loads
Y. Chevalier, M. Charlebois, D. Pahr, P. Varga, P. Heini, E. Schneider, P. Zysset
Published 2008 · Engineering, Medicine
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Due to the inherent limitations of DXA, assessment of the biomechanical properties of vertebral bodies relies increasingly on CT-based finite element (FE) models, but these often use simplistic material behaviour and/or single loading cases. In this study, we applied a novel constitutive law for bone elasticity, plasticity and damage to FE models created from coarsened pQCT images of human vertebrae, and compared vertebral stiffness, strength and damage accumulation for axial compression, anterior flexion and a combination of these two cases. FE axial stiffness and strength correlated with experiments and were linearly related to flexion properties. In all loading modes, damage localised preferentially in the trabecular compartment. Damage for the combined loading was higher than cumulated damage produced by individual compression and flexion. In conclusion, this FE method predicts stiffness and strength of vertebral bodies from CT images with clinical resolution and provides insight into damage accumulation in various loading modes.
This paper references
Cortical and Trabecular Load Sharing in the Human Vertebral Body
S. Eswaran (2006)
Effect of bone distribution on vertebral strength: assessment with patient-specific nonlinear finite element analysis.
K. Faulkner (1991)
Locations of bone tissue at high risk of initial failure during compressive loading of the human vertebral body.
S. Eswaran (2007)
Sensitivity of vertebral compressive strength to endplate loading distribution.
J. Buckley (2006)
Nonlinear Finite Element Model Predicts Vertebral Bone Strength and Fracture Site
K. Imai (2006)
Age-related changes in bone mass, structure, and strength – effects of loading
L. Mosekilde (2000)
Quantitative Computed Tomography-Based Predictions of Vertebral Strength in Anterior Bending
J. Buckley (2007)
Noninvasive assessment of stiffness and failure load of humane vertebrae from CT data
H. Martin (2006)
Elastic plastic damage constitutive laws for cortical bone
D. Garcia (2006)
A biomechanical perspective on bone quality.
C. Hernandez (2006)
Finite Element Modeling of the Human Thoracolumbar Spine
M. Liebschner (2003)
Regional variation in vertebral bone morphology and its contribution to vertebral fracture strength.
P. A. Hulme (2007)
Direct and computed tomography thickness measurements of the human, lumbar vertebral shell and endplate.
M. Silva (1994)
An Alternative Fabric-based Yield and Failure Criterion for Trabecular Bone
P. Zysset (2006)
Identification of a multiaxial failure criterion for human trabecular bone
Liliana Rincón Kohli (2003)
Finite element models predict in vitro vertebral body compressive strength better than quantitative computed tomography.
R. Crawford (2003)
An alternative model for anisotropic elasticity based on fabric tensors
P. Zysset (1995)
Effects of Teriparatide and Alendronate on Vertebral Strength as Assessed by Finite Element Modeling of QCT Scans in Women With Osteoporosis
T. M. Keaveny (2007)
Noninvasive Imaging Predicts Failure Load of the Spine with Simulated Osteolytic Defects*†
K. M. Whealan (2000)
Relationship Between Axial and Bending Behaviors of the Human Thoracolumbar Vertebra
R. Crawford (2004)
Biomechanical consequences of an isolated overload on the human vertebral body
D. Kopperdahl (2000)
Accuracy of cancellous bone volume fraction measured by micro-CT scanning.
M. Ding (1999)
Properties of acrylic bone cement: state of the art review.
G. Lewis (1997)
Classification of vertebral fractures
R. Eastell (1991)
Computed tomography‐based finite element analysis predicts failure loads and fracture patterns for vertebral sections
M. Silva (1998)
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A calibration methodology of QCT BMD for human vertebral body with registered micro-CT images.
E. Dallara (2011)
Simulation of the Fatigue Performance of Spinal Vertebrae
Ruth Helen Coe (2018)
Development, validation and clinical evaluation of a subject-specific finite element model of the vertebra with adjacent intervertebral disc to estimate vertebral strength
Chuhee Lee (2014)
Bioinspired Layered Composite Principles of Biomineralized Fish Scale
Matthew Nelms (2018)
Calibration of the mechanical properties in a finite element model of a lumbar vertebra under dynamic compression up to failure
Anaïs Garo (2011)
Osteoporosis imaging: effects of bone preservation on MDCT-based trabecular bone microstructure parameters and finite element models
T. Baum (2015)
A predictive mechanical model for evaluating vertebral fracture probability in lumbar spine under different osteoporotic drug therapies
Enrique López (2016)
Elastic Anisotropy of Trabecular Bone in the Elderly Human Vertebra.
G. Unnikrishnan (2015)
An experimental and computational investigation of the post-yield behaviour of trabecular bone during vertebral device subsidence
N. Kelly (2013)
Modélisation du corps vertébral en chargement dynamique : Intégration de l'effet de l'âge
Anaïs Garo (2010)
Variogram-based evaluations of DXA correlate with vertebral strength, but do not enhance the prediction compared to aBMD alone.
X. Dong (2018)
Vertebral strength prediction from Bi-Planar dual energy x-ray absorptiometry under anterior compressive force using a finite element model: An in vitro study.
Julie Choisne (2018)
Embedding of human vertebral bodies leads to higher ultimate load and altered damage localisation under axial compression
G. Maquer (2014)
A NEW METHOD TO DETERMINE VOLUMETRIC BONE MINERAL DENSITY FROM BI-PLANAR DUAL ENERGY RADIOGRAPHS USING A FINITE ELEMENT MODEL: AN EX-VIVO STUDY
Julie Choisne (2017)
A comparison of enhanced continuum FE with micro FE models of human vertebral bodies.
D. Pahr (2009)
Validation of an HR-pQCT-based homogenized finite element approach using mechanical testing of ultra-distal radius sections
P. Varga (2011)
3.10 Finite Element Analysis in Bone Research: A Computational Method Relating Structure to Mechanical Function☆
D. Ruffoni (2017)
Biomechanics of spinal metastases
Ondřej Holub (2014)
Improvements in Vertebral Body Strength Under Teriparatide Treatment Assessed In Vivo by Finite Element Analysis: Results From the EUROFORS Study
C. Graeff (2009)
Effect of variations in tissue-level ductility on human vertebral strength.
Saghi Sadoughi (2020)
The Initial Slope of the Variogram, Foundation of the Trabecular Bone Score, Is Not or Is Poorly Associated With Vertebral Strength
G. Maquer (2016)
Prediction of lumbar vertebral body compressive strength of overweight and obese older adults using morphed subject-specific finite-element models to evaluate the effects of weight loss
Samantha L. Schoell (2018)
Effect of screw position on load transfer in lumbar pedicle screws: a non-idealized finite element analysis
A. Newcomb (2017)
Finite element analysis predicts experimental failure patterns in vertebral bodies loaded via intervertebral discs up to large deformation.
Allison L. Clouthier (2015)
Finite element analysis for prediction of bone strength.
P. Zysset (2013)
Generation of mineral density distribution maps from subject-specific models of mandibles - a preliminary study.
Francisco Alister (2012)
Quantifying the response of vertebral bodies to compressive loading using digital image correlation
Hannah M Gustafson (2016)
Effect of fabric on the accuracy of computed tomography-based finite element analyses of the vertebra
Y. Wu (2019)
Fast estimation of Colles' fracture load of the distal section of the radius by homogenized finite element analysis based on HR-pQCT.
H. S. Hosseini (2017)
Prediction of failure in cancellous bone using extended finite element method
Mohammad Salem (2020)
Effect of the intervertebral disc on vertebral bone strength prediction: a Finite-Element Study.
D. Anitha (2019)
Compressive strength of elderly vertebrae is reduced by disc degeneration and additional flexion.
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