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Continuous Synthesis And Anti-myocardial Injury Of Tanshinone IIA Derivatives

Yin-lin Qin, Lei Chen, Wei He, M. Su, Q. Jin, Z. Fang, P. Ouyang, Kai Guo
Published 2018 · Chemistry, Medicine

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Abstract A series of tanshinone IIA derivatives were synthesized through sulfonation, slat-forming, chlorination, and amidation reactions. Meanwhile, anti-myocardial injury activity was evaluated in vitro. D8 and D9 exhibited a slightly higher anti-myocardial injury (5.78, 7.46 μM) activity compared with esmolol (8.12 μM). In addition, they also displayed a concentration-dependent inhibition on the anti-myocardial injury.
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