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Silica Sulfuric Acid (SSA) As A Highly Efficient Heterogeneous Catalyst For Persilylation Of Purine And Pyrimidine Nucleobases And Other N-Heterocycles Using Hmds

M. Rad, A. Khalafi-nezhad, Masoumeh Divar, S. Behrouz
Published 2010 · Chemistry

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Purine and pyrimidine nucleobases and other N-heterocycles have been silylated with HMDS in excellent yields in the presence of a catalytic amount of silica sulfuric acid (SSA) as a heterogeneous catalyst. SSA utilizes a shorter reaction time and higher yields of silylated nucleobases. SSA is reusable for several times without a decrease in reactivity or yield of silylated adducts.
This paper references
Purification by column chromatography on silica gel using EtOAc/n-hexane (1:2) afforded white crystals (2.8 g, 87%)
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Entry 13) Purification by column chromatography on silica gel using EtOAc/n-hexane (1:2) afforded white crystals (2.1 g, 90%)
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