Online citations, reference lists, and bibliographies.

Chitosan-Based Particles As Controlled Drug Delivery Systems

Mani Prabaharan, João F Mano
Published 2005 · Materials Science, Medicine
Cite This
Download PDF
Analyze on Scholarcy
Share
Chitosan, a natural-based polymer obtained by alkaline deacetylation of chitin, is nontoxic, biocompatible, and biodegradable. These properties make chitosan a good candidate for conventional and novel drug delivery systems. This article reviews the approaches aimed to associate bioactive molecules to chitosan in the form of colloidal structures and analyzes the evidence of their efficacy in improving the transport of the associated molecule through mucosae and epithelia. Chitosan forms colloidal particles and entraps bioactive molecules through a number of mechanisms, including chemical crosslinking, ionic crosslinking, and ionic complexation. A possible alternative of chitosan by the chemical modification also has been useful for the association of bioactive molecules to polymer and controlling the drug release profile. Because of the high affinity of chitosan for cell membranes, it has been used as a coating agent for liposome formulations. This review also examines the advances in the application of chitosan and its derivatives to nonviral gene delivery and gives an overview of transfection studies that use chitosan as a transfection agent. From the studies reviewed, we concluded that chitosan and its derivatives are promising materials for controlled drug and nonviral gene delivery.
This paper references
10.1002/app.1991.070420110
Protease immobilization onto porous chitosan beads
Toshio Hayashi (1991)
DNA-chitosan nanospheres, transfection efficiency and cellular uptake
K Roy (1997)
In vitro evaluation
M. D. 243828–3833. Hornof (2003)
Formulation and charecterization of pH sensitive drug carrier based on phosphorylated chitosan. Carbohydrate Polym
P P Win (2003)
10.1246/cl.1996.725
Formation of a DNA/polygalactosamine Complex and Its Interaction with Cells
Toshinori Sato (1996)
N-succinyl-chitosan 及びその糖鎖修飾体を薬物担体とした制癌薬プロドラッグの肝転移癌モデルマウスに対する延命効果-単回及び複数回投与による比較
加藤 良規 (2001)
10.1016/S0378-5173(98)00266-X
Investigation of a pMDI system containing chitosan microspheres and P134a
Robert O Williams (1998)
A novel water-soluble N-succinyl-chitosan-mitomycin C conjugate prepared by direct carbodiimide coupling: physicochemical properties, antitumor characteristics and systemic retention
Yoshinori Kato (2000)
Application of nanoparticles based on hydrophilic polymers as pharmaceutical forms
M J Alonso (1998)
Evaluation of the biological properties of different wound dressing materials
P C Bersch (1995)
10.1016/S0168-3659(00)00298-4
Galactosylated chitosan-graft-dextran as hepatocyte-targeting DNA carrier.
In-Kyu Park (2000)
10.1016/0142-9612(93)90136-P
Chitosan matrix for oral sustained delivery of ampicillin.
Thomas P Chandy (1993)
Oral gene deliv
H. Q. Mao (1999)
10.1016/S0144-8617(96)00154-3
Design of quaternary chitosan conjugate having antennary galactose residues as a gene delivery tool
Jun-ichi Murata (1997)
10.1016/S0378-5173(03)00271-0
Thiolated polymers--thiomers: synthesis and in vitro evaluation of chitosan-2-iminothiolane conjugates.
Andreas Bernkop-Schnürch (2003)
10.1007/PL00000584
Human enzymatic activities related to the therapeutic administration of chitin derivatives
Riccardo A. A. Muzzarelli (1997)
Macromolecular prodrugs of cytarabine and mitomycin C with chitosan, Nsuccinyl chitosan and 6-O-carboxymethyl-chitin as drug carriers
H Onishi (1994)
Protease immobilization onto porous chitosan
T. Hayashi (1991)
10.1016/0378-5173(96)04613-3
Mucoadhesive polymers in peroral peptide drug delivery. V. Effect of poly(acrylates) on the enzymatic degradation of peptide drugs by intestinal brush border membrane vesicles
Henrik L. Lueβen (1996)
10.1038/351302a0
Saccharide-sensitive phase transition of a lectin-loaded gel
Etsuo Kokufata (1991)
Preparation and drug
M. Sato (1996)
10.1016/S0927-7765(99)00157-5
The role of PEG on the stability in digestive fluids and in vivo fate of PEG-PLA nanoparticles following oral administration.
Tobío (2000)
10.1016/0032-9592(95)00076-3
Calcium-alginate beads coated with polycationic polymers: Comparison of chitosan and DEAE-dextran
Marie Laure Huguet (1996)
10.1081/MA-100101566
STRUCTURAL CHANGES AND RELEASE CHARACTERISTICS OF CROSSLINKED CHITOSAN BEADS IN RESPONSE TO SOLUTION pH
Kailash Chandra Gupta (1999)
Evaluation of the biological
B. Nies (1995)
Influence of cross-linking
A. Berthold (1996)
10.2745/dds.11.119
Chitosan capsules for colon-specific drug delivery: improvement of insulin absorption from the rat colon.
Hideyuki Tozaki (1996)
PREPARATION AND CHARACTERIZATION OF
Cecilia Paglier (1996)
Chitin and chitosan: source, chemistry, biochemistry, physical properties and applications
J Knapczyk (1989)
Application of Chitin, Chitosan, and their Derivatives to Drug Carriers for Microparticulated or Conjugated Drug Delivery System
H Onishi (1997)
10.1016/j.ijpharm.2003.12.026
Chitosan microspheres as a potential carrier for drugs.
V R Sinha (2004)
10.1248/cpb.40.2822
Synthesis and drug-release characteristics of the conjugates of mitomycin C with N-succinyl-chitosan and carboxymethyl-chitin.
Yingwen Song (1992)
10.1016/S0168-3659(02)00146-3
Thermosensitive chitosan-based hydrogel containing liposomes for the delivery of hydrophilic molecules.
Ève Ruel-Gariépy (2002)
Natural chelating polymers
R. Muzzarelli (1973)
10.1023/A:1011922819926
Stealth PLA-PEG Nanoparticles as Protein Carriers for Nasal Administration
María Tobío (2004)
10.1016/S0939-6411(02)00162-5
In vitro evaluation of the viscoelastic properties of chitosan-thioglycolic acid conjugates.
Margit D Hornof (2003)
10.1081/DDC-100107322
Preparation and In Vitro Properties of N-Succinylchitosan– or Carboxymethylchitin–Mitomycin C Conjugate Microparticles with Specified Size
H. Russell Onishi (2001)
10.1021/jo01110a017
The Use of Water-Soluble and Basic Carbodiimides in Peptide Synthesis
John C. Sheehan (1956)
A biocompatible
H. Hirano (1990)
Formulation and charecterization of pH sensitive drug carrier based on phosphorylated chitosan
P. P. Win (2003)
A novel water-soluble N-succinyl
Y. Kato (2000)
The complex carbohydrates of mammalian cell surfaces and their biological roles.
Hughes Rc (1975)
10.1016/S0168-3659(03)00196-2
Release phenomena of insulin from an implantable device composed of a polyion complex of chitosan and sodium hyaluronate.
Silvia Surini (2003)
10.1016/0168-3659(96)01372-7
Drug release and antitumor characteristics of N-succinyl-chitosanmitomycin C as an implant
Youhua Song (1996)
Stabilization of colloidal systems by the formation of ionic lipid-polysaccharide complexes
M J Alonso (1997)
Oral delivery of plasmid DNA encoding the factor IX gene
G Okoli (2000)
10.1002/(SICI)1097-4628(19970124)63:4<425::AID-APP3>3.0.CO;2-T
Polyelectrolyte Complexes of Sodium Alginate with Chitosan or Its Derivatives for Microcapsules
Kuen Yong Lee (1997)
Influence of crosslinking on the acid stability and physicochemical properties of chitosan microspheres
Achim Berthold (1996)
Synthesis and charecterization of a novel chitosan.based network prepared using naturally occuring crosslinker
F. L. Mi (2000)
10.1016/S0168-3659(97)00173-9
Preparation of chitosan self-aggregates as a gene delivery system.
K. Lee (1998)
10.1007/978-94-011-5942-5_76
An Overview of the Regulatory Status and of the Safety of Chitin and Chitosan as Food and Pharmaceutical Ingredients
Myra L. Weiner (1992)
10.1016/S0169-409X(00)00123-X
Polysaccharide colloidal particles as delivery systems for macromolecules.
Kenneth A. Janes (2001)
10.1248/bpb.19.241
Preparation and drug release characteristics of the conjugates of mitomycin C with glycol-chitosan and N-succinyl-chitosan.
Miho Sato (1996)
10.1016/0001-8686(94)80021-9
Novel silica-biopolymer nanocomposites: the silica sol-gel process in biopolymer organogels
Heribert J. Watzke (1994)
10.2165/00128415-200711590-00025
Calcium alginate
DR.HARIKRISHNA K. R. Nair (2007)
10.1016/S0142-9612(99)00064-2
Porous chitosan microsphere for controlling the antigen release of Newcastle disease vaccine: preparation of antigen-adsorbed microsphere and in vitro release.
Fwu-Long Mi (1999)
10.1016/0169-409X(88)90019-1
Polymeric controlled drug delivery
Kam W. Leong (1988)
Modified chitosan oligosaccharides as transfection agents for gene therapy of cystic fibrosis
B. I. Florea (2000)
10.1016/S0168-3659(01)00486-2
Design of biodegradable particles for protein delivery.
Ana Fernández Vila (2002)
10.1038/241483a0
Transport Kinetics
W. D. Stein (1973)
10.1002/(SICI)1097-4628(19970103)63:1<125::AID-APP13>3.0.CO;2-4
Novel hydrophilic chitosan‐polyethylene oxide nanoparticles as protein carriers
Pilar Abad Calvo (1997)
10.1016/S0144-8617(02)00257-6
Miconazole-loaded 6-oxychitin–chitosan microcapsules
Ida Genta (2003)
10.1016/S0168-3659(02)00005-6
The release of model macromolecules may be controlled by the hydrophobicity of palmitoyl glycol chitosan hydrogels.
Lee Martin (2002)
Oligonucleotide-chitosan nanoparticles as new gene therapy vector
P. Calvo (1998)
10.1126/science.277.5328.949
Conversion by Peyer's patch lymphocytes of human enterocytes into M cells that transport bacteria.
Sophie Kernéis (1997)
10.1023/A:1018901302450
Chitosan as a Novel Nasal Delivery System for Peptide Drugs
Lisbeth Illum (2004)
10.1016/S0168-3659(97)00252-6
DNA-polycation nanospheres as non-viral gene delivery vehicles.
Kam W. Leong (1998)
10.1177/088532828600100306
Inhibition of Platelet Adhesion to Glow Discharge Modified Surfaces
Chandra P. Sharma (1986)
10.1248/bpb.19.1170
In vivo drug release and antitumor characteristics of water-soluble conjugates of mitomycin C with glycol-chitosan and N-succinyl-chitosan.
Miho Sato (1996)
10.1016/S0144-8617(02)00211-4
Modified chitosan carrying phosphonic and alkyl groups
Viviana Monica Ramos (2003)
10.1016/S0144-8617(98)00022-8
Influence of glutaraldehyde on drug release and mucoadhesive properties of chitosan microspheres
Ida Genta (1998)
10.1016/S0008-6215(00)84614-5
Preparation of partially N-succinylated chitosans and their cross-linked gels
Ryuji Yamaguchi (1981)
Chitosan as absorption enhancers for poorly absorbable drugs
N.G.M. Schipper (1997)
10.1002/(SICI)1521-3935(19980401)199:4<705::AID-MACP705>3.0.CO;2-9
Modulated degradation of hydrogels with thermo‐responsive network in relation to their swelling behavior
Motoichi Kurisawa (1998)
10.1016/S0168-3659(01)00294-2
Chitosan nanoparticles as delivery systems for doxorubicin.
Kenneth A. Janes (2001)
10.1016/0168-3659(95)00129-8
Preparation and characterization of chitosan microspheres as drug carrier for prednisolone sodium phosphate as model for anti-inflammatory drugs
Achim Berthold (1996)
10.1016/S0378-5173(02)00421-0
Effect of chitosan on in vitro release and ocular delivery of ofloxacin from erodible inserts based on poly(ethylene oxide).
Giacomo Di Colo (2002)
10.1016/0142-9612(92)90119-9
Chitosan beads and granules for oral sustained delivery of nifedipine: in vitro studies.
Thomas P Chandy (1992)
Chitin and chitosan: source, chemistry, biochem
H. Struszcyk (1989)
murine model of peanut allergy
H. Q. Mao (1997)
10.1016/S0168-3659(97)00203-4
Design of microencapsulated chitosan microspheres for colonic drug delivery.
M L Lorenzo-Lamosa (1998)
10.1023/A:1012160102740
Chitosans as Absorption Enhancers for Poorly Absorbable Drugs 2: Mechanism of Absorption Enhancement
Nicolaas G. M. Schipper (2004)
10.1016/S0168-3659(03)00327-4
N-acylated chitosan: hydrophobic matrices for controlled drug release.
Canh Le Tien (2003)
10.1023/A:1016488623022
Mucoadhesive Polymers in Peroral Peptide Drug Delivery. VI. Carbomer and Chitosan Improve the Intestinal Absorption of the Peptide Drug Buserelin In Vivo
H. L. Luessen (2004)
Novel polymeric condensing carriers for gene delivery
Russell J. Mumper (1995)
An efficient method for the synthesis of novel
K. Kurita (1993)
The complex carbohydrates of mammalian cell surfaces and their biological roles.
R C Hughes (1975)
10.1023/A:1018967116988
Effect of Chitosan on the Permeability of Monolayers of Intestinal Epithelial Cells (Caco-2)
Per Artursson (2004)
10.1002/pol.1971.150091005
Permeability of membranes containing ionogenic groups
Jindřich Kopeček (1971)
10.1081/DDC-100000124
Polymeric Controlled Drug-Delivery Systems: Perspective Issues and Opportunities
Majeti N. V. Ravi Kumar (2001)
10.1073/pnas.87.10.3655
Receptor-mediated endocytosis of transferrin-polycation conjugates: an efficient way to introduce DNA into hematopoietic cells.
Martin Zenke (1990)
Hemoglobin encapsulation in chitosan/calcium alginate beads
M L Huguet (1994)
Transport kinetics of DNA nanopartilces in a Caco-2-peyer's patch model of intestinal epithelium
I Kadiyala (2000)
Particle characteristics of carboxymethyl chitin–mitomycin C conjugate and their distribution and histological effect on some tissues after intravenous administration
Y. Song (1995)
10.1080/15321799508014592
Microcapsules/Microspheres Related to Chitosan
Kangde Yao (1995)
A biocompatible material for oral and intravenous administration
H Hirano (1990)
Chitin and chitosan : sources, chemistry, biochemistry, physical properties, and applications
Thorleif Anthonsen (1989)
10.1016/j.jconrel.2003.10.005
Thiolated chitosans: development and in vitro evaluation of a mucoadhesive, permeation enhancing oral drug delivery system.
Andreas Bernkop-Schnürch (2004)
10.1016/0378-5173(94)90344-1
Preparation and evaluation of cross-linked chitosan microspheres containing furosemide
Julide Akbuǧa (1994)
10.1016/S0142-9612(02)00071-6
Synthesis and characterization of chitosan-poly(acrylic acid) nanoparticles.
Yong Hu (2002)
10.1016/S0142-9612(99)00263-X
Drug release behavior of beads and microgranules of chitosan.
Kailash Chand Gupta (2000)
DNAchitosan nanoparticles for gene delivery
H. Q. Mao (1996)
DNAchitosan nanospheres, derivitization and storage stability
H. Q. Mao (1997)
Mitomycin basic studies
K. Shirahata (1984)
An efficient method for the synthesis of novel amphiphilic polysaccharide by region and thermo selective modifications of chitosan
S Nishimura (1993)
Chitosan-based gastrointestinal delivery
R. Hejazi (2003)
10.1271/bbb.59.1901
Chitosan-derived polymer-surfactants and their micellar properties.
Hiroe Yoshioka (1995)
10.1016/0378-5173(92)90353-4
In vitro evaluation of mucoadhesive properties of chitosan and some other natural polymers
Claus-Michael Lehr (1992)
10.1016/S0939-6411(03)00157-7
Mucoadhesive thiolated chitosans as platforms for oral controlled drug delivery: synthesis and in vitro evaluation.
Marta Roldo (2004)
10.1002/pi.1994.210340213
PH-DEPENDENT HYDROLYSIS AND DRUG-RELEASE OF CHITOSAN POLYETHER INTERPENETRATING POLYMER NETWORK HYDROGEL
K. Yao (1994)
10.1038/346345a0
Phase transition in polymer gels induced by visible light
Atsushi Suzuki (1990)
10.1016/S0928-0987(01)00172-5
Chitosan and its derivatives in mucosal drug and vaccine delivery.
I M van der Lubben (2001)
10.1016/S0032-9592(96)00032-5
CALCIUM ALGINATE BEADS COATED WITH CHITOSAN : EFFECT OF THE STRUCTURE OF ENCAPSULATED MATERIALS ON THEIR RELEASE
Marie Laure Huguet (1996)
10.1080/10601329409349743
Release Behavior of 5-Fluorouracil from Chitosan-Gel Nanospheres Immobilizing 5-Fluorouracil Coated with Polysaccharides and Their Cell Specific Cytotoxicity
Yuichi Ohya (1994)
10.1016/S1359-0294(97)80103-3
Hydrogels and drug delivery
Nikolaos A. Peppas (1997)
Oral delivery of plasmid DNA
G. Chem. A31629–642. Okoli (2000)
Effect of chitosan
A. A1. Artursson (1994)
Applications of chitin and chitosan
M. F. A. Goosen (1997)
10.1016/S0378-5173(01)00763-3
Quaternary ammonium palmitoyl glycol chitosan--a new polysoap for drug delivery.
I. Uchegbu (2000)
10.1038/7385
Oral gene delivery with chitosan–DNA nanoparticles generates immunologic protection in a murine model of peanut allergy
Krishnendu Roy (1999)
10.1016/0376-7388(91)80085-K
Pervaporation separation of water—ethanol through modified chitosan membranes. IV. Phosphorylated chitosan membranes
Young Moo Lee (1991)
10.1016/0378-5173(94)90218-6
Interactions between liposomes and chitosan
Ingrid Henriksen (1994)
10.1023/A:1018908705446
Enhancement of Nasal Absorption of Insulin Using Chitosan Nanoparticles
Rocío Fernández-Urrusuno (2004)
Development of a freeze-dried formulation of insulin-loaded chitosan nanoparticles intended for nasal administration
Rocío Fernández-Urrusuno (1999)
10.1016/S0169-409X(01)00171-5
Chitosan as a novel nasal delivery system for vaccines.
Lisbeth Illum (2001)
10.1002/jbm.820200910
Macrophage activation with multi-porous beads prepared from partially deacetylated chitin.
Kazumi Nishimura (1986)
Preparation and evaluation of cross-linked
J. Akbuga (1994)
10.1016/S0142-9612(00)00421-X
Thiolated polymers--thiomers: development and in vitro evaluation of chitosan-thioglycolic acid conjugates.
C. Kast (2001)
Biocompatibility of chitosan by oral and intravenous administration
S Hirano (1989)
10.1016/S0142-9612(01)00094-1
In vivo biocompatibility and degradability of a novel injectable-chitosan-based implant.
Fwu-Long Mi (2002)
10.1016/S0142-9612(03)00579-9
Chitosan-poly(acrylic) acid polyionic complex: in vivo study to demonstrate prolonged gastric retention.
Susana Torrado (2004)
10.1016/0927-7757(93)80343-D
Stabilization by chitosan of soybean oil emulsions coated with phospholipid and glycocholic acid
Pia Fäldt (1993)
Drug release behavior of chitosan/gelatin network polymer microsphere
尹玉姬 (1996)
10.1016/S0939-6411(02)00052-8
The influence of multivalent phosphate structure on the properties of ionically cross-linked chitosan films for controlled drug release.
X Z Shu (2002)
10.1016/S0378-5173(00)00533-0
Preparation and in-vitro evaluation of poly[N-vinyl-2-pyrrolidone-polyethylene glycol diacrylate]-chitosan interpolymeric pH-responsive hydrogels for oral drug delivery.
K. L. Shantha (2000)
A novel approach to the delivery of microparticles or nanoparticles
R. Bodmeier (1989)
10.1023/A:1011901921995
Development of Novel Chitosan Derivatives as Micellar Carriers of Taxol
Akio Miwa (1998)
Colon-specific delivery of peptide drugs and anti-inflammatory drugs using chitosan capsules
Akira Yamamoto (2000)
10.1002/(SICI)1097-4628(20000502)76:5<672::AID-APP9>3.0.CO;2-F
Semi-interpenetrating polymer network beads of crosslinked chitosan–glycine for controlled release of chlorphenramine maleate
Kailash Chand Gupta (2000)
10.1016/S0024-3205(99)00044-2
Colon-specific delivery of R68070, a new thromboxane synthase inhibitor, using chitosan capsules: therapeutic effects against 2,4,6-trinitrobenzene sulfonic acid-induced ulcerative colitis in rats.
Hideyuki Tozaki (1999)
Calcium alginate beads coated
M. L. 111–36. Huguet (1996)
Chitin enzymology-chitinase
D Koga (1998)
Chitosan derivatives bearing C10 alkyl glycosides
K. Holme (1991)
Interactions between liposomes
I. Henriksen (1994)
10.1016/S0939-6411(97)00056-8
Development and characterization of protein-loaded poly(lactide-co-glycolide) nanospheres
M. Dolores Blanco (1997)
10.1002/app.1993.070500216
Synthesis of N‐(aminoalkyl) chitosan for microcapsules
E. J. Dunn (1993)
10.1002/(SICI)1097-0126(200002)49:2<141::AID-PI303>3.0.CO;2-0
Preparation, characterization and release profiles of pH‐sensitive chitosan beads
Kailash Chandra Gupta (2000)
10.1023/A:1011929016601
Chitosan and its use as a pharmaceutical excipient.
Lisbeth Illum (1998)
10.1016/S0168-3659(03)00126-3
Chitosan-based gastrointestinal delivery systems.
Radi Hejazi (2003)
10.1021/ma00013a014
Chitosan derivatives bearing C10-alkyl glycoside branches : a temperature-induced gelling polysaccharide
Kevin R. Holme (1991)
10.1016/S0378-5173(96)04847-8
Evaluation of the biological properties of soluble chitosan and chitosan microspheres
B. Carreño-Gómez (1997)



This paper is referenced by
10.1177/0883911506066929
Phosphorous Containing Chitosan Beads for Controlled Oral Drug Delivery
Rangasamy Jayakumar (2006)
10.1016/J.JDDST.2019.01.027
Preparation, characterization and stability evaluation of ionic liquid blended chitosan tripolyphosphate microparticles
Rizwan Safdar (2019)
10.1002/bit.22004
Poly(N-isopropylacrylamide) surface-grafted chitosan membranes as a new substrate for cell sheet engineering and manipulation.
Ricardo M P da Silva (2008)
10.22037/IJPR.2018.2199
Promoting Probiotics Survival by Microencapsualtion with Hylon Starch and Genipin Cross-linked Coatings in Simulated Gastro-intestinal Condition and Heat Treatment
Mohammad Ali Khosravi Zanjani (2018)
POLYSACCHARIDE NANOPARTICLES: PREPARATION AND THEIR POTENTIAL APPLICATION AS DRUG DELIVERY SYSTEMS
V. N. L. Sirisha (2015)
10.1080/10601325.2019.1578616
Synthesis, characterization and antimicrobial activity of maltol functionalized chitosan derivatives
Rajendra Saud (2019)
10.1016/J.MATLET.2012.01.008
Investigating structure and fluorescence properties of green fluorescent protein released from chitosan nanoparticles
Vinod Kumar Yata (2012)
10.1002/APP.33436
Preparation and properties of chitosan-graft-poly(methyl methacrylate) nanoparticles using potassium diperiodatocuprate (III) as an initiator
Zhanjun Liu (2011)
Survival of alginate-prebiotic microencapsulated Lactobacillus acidophilus in mayonnaise sauce
Sibericat Branch (2013)
10.5772/13509
Novel Chitin and Chitosan Materials in Wound Dressing
Rangasamy Jayakumar (2011)
10.1016/j.ejpb.2008.06.008
Understanding the adsorption mechanism of chitosan onto poly(lactide-co-glycolide) particles.
Chunqiang Guo (2008)
10.1111/rda.13346
Gonadotropin‐releasing hormone‐modified chitosan as a safe and efficient gene delivery vector for spermatogonia cells
Chatwalee Boonthum (2018)
10.4028/www.scientific.net/AMR.586.161
The Preparation and Characteristics of Chitosan-Acetaminophen Drug-Loading Micropheres
Hao Zhou (2012)
10.1016/j.ijbiomac.2019.09.254
Cross-linked chitosan microparticles preparation by modified three fluid nozzle spray drying approach.
M. Gover Antoniraj (2019)
10.18297/ETD/1395
Chitosan nanoparticles to encapsulate a biofilm degrading enzyme for treatment of CRBSI
Lindsay N. Strotman (2010)
Development of different drug delivery systems for skin regeneration
Patrícia I. Morgado (2011)
10.1016/j.ejmech.2018.08.080
Nano-scale drug delivery systems for antiarrhythmic agents.
A. Nadimi (2018)
10.3390/polym10050536
Effect of Chemical Disinfection on Chitosan Coated PMMA and PETG Surfaces—An In Vitro Study
Katarzyna Walczak (2018)
10.1039/C4PY00173G
Short peptide based self-assembled nanostructures: implications in drug delivery and tissue engineering
Jiban Jyoti Panda (2014)
10.4038/JNSFSR.V44I2.7997
Release behaviour of amoxicillin from chitosan coated liposomes derived from eggs
M.A.S.K. Menikarachchi (2016)
Development of different drug delivery systems for skin regeneration
Ciências da Saúde (2011)
10.1002/APP.44904
Preparation of chitin‐CdTe quantum dots films and antibacterial effect on Staphylococcus aureus and Pseudomonas aeruginosa
Poorna T. Wansapura (2017)
10.1016/J.JMMM.2017.09.018
A simple approach to design chitosan functionalized Fe3O4 nanoparticles for pH responsive delivery of doxorubicin for cancer therapy
Mahesh G Adimoolam (2018)
10.1002/jbm.b.32662
Chitosan as a barrier membrane material in periodontal tissue regeneration.
Chun Xu (2012)
10.1016/j.carbpol.2016.09.015
Chitosan-based DNA delivery vector targeted to gonadotropin-releasing hormone (GnRH) receptor.
Chatwalee Boonthum (2017)
10.1166/JBT.2012.1030
Biomedical Applications of Chitosan: An Overview
R. Ramya (2012)
10.1088/1758-5082/4/1/015002
Air plasma treated chitosan fibers-stacked scaffolds.
Shan-Hui Hsu (2012)
10.1016/j.ijpharm.2018.11.032
Biocompatible nanoparticles and vesicular systems in transdermal drug delivery for various skin diseases
Prerana Carter (2019)
10.1002/CBEN.201400025
A Review on Chitin and Chitosan Polymers: Structure, Chemistry, Solubility, Derivatives, and Applications
Vida Zargar (2015)
10.1016/j.ijbiomac.2015.01.008
Synthesis of chitosan-g-poly(acrylamide)/ZnS nanocomposite for controlled drug delivery and antimicrobial activity.
Divya Gupta (2015)
10.1007/978-81-322-2511-9_7
Chitin, Chitosan, and Silk Fibroin Electrospun Nanofibrous Scaffolds: A Prospective Approach for Regenerative Medicine
Brijesh Kumar Singh (2016)
10.1016/j.apsb.2018.01.013
Designing the new generation of intelligent biocompatible carriers for protein and peptide delivery
Angela M. Wagner (2018)
See more
Semantic Scholar Logo Some data provided by SemanticScholar