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Asbestos-related Cancers: The ‘Hidden Killer’ Remains A Global Threat
N. van Zandwijk, G. Reid, A. Frank
Published 2020 · Medicine
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ABSTRACT Introduction: Asbestos, the most frequent cause of occupational cancer, continues to be consumed on a massive scale, with millions of people exposed on a daily basis. This review explains why we have failed in curtailing the silent epidemic of asbestos-related disease and why the numbers of asbestos victims are likely to remain high. Emerging and developed countries have to be reminded that asbestos exposure has yet to become a problem of the past. The worldwide spread of asbestos, followed by the surge of asbestos-related cancers, resembles the lung cancer epidemic caused by smoking and stimulated by manufacturers. Areas covered: Underreporting of malignant mesothelioma and asbestos-induced lung cancer, frequently-used arguments in the amphibole/chrysotile debate and the conclusion from bona-fide research organizations, that all forms of asbestos are carcinogenic, are reviewed. Special attention is paid to the consequences of ubiquitous environmental asbestos and the ‘changing face’ of malignant mesothelioma in countries with heavy asbestos use in the past. Expert opinion: Experts in oncology, respiratory medicine, occupational and public health, and basic researchers must take responsibility and acknowledge the ongoing silent epidemic of asbestos-related diseases. The call for a world-wide asbestos ban is more urgent than ever.
This paper references
Manipulating microRNAs for the Treatment of Malignant Pleural Mesothelioma: Past, Present and Future
G. Reid (2020)
Italian pool of asbestos workers cohorts: mortality trends of asbestos-related neoplasms after long time since first exposure
D. Ferrante (2017)
Asbestos-associated diseases in a cohort of cigarette-filter workers.
J. Talcott (1989)
Toward an Asbestos Ban in the United States
R. Lemen (2017)
Asbestos fiber length as related to potential pathogenicity: a critical review.
R. Dodson (2003)
Fibre Cement Products Manufacturers Association
A Meta-Analysis of Asbestos-Related Cancer Risk That Addresses Fiber Size and Mineral Type
D. Berman (2008)
• Excellent long-term follow-up study showing the devastating consequences of asbestos exposure during childhood
Occupational Asbestos Exposure and Lung Cancer—A Systematic Review of the Literature
Lene Snabe Nielsen (2014)
Challenges and controversies in the diagnosis of malignant mesothelioma: Part 2. Malignant mesothelioma subtypes, pleural synovial sarcoma, molecular and prognostic aspects of mesothelioma, BAP1, aquaporin-1 and microRNA
D. Henderson (2013)
Non-asbestos-related malignant mesothelioma
Peterson JT (1984)
Zeolites ameliorate asbestos toxicity in a transgenic model of malignant mesothelioma
Xiyong Fan (2019)
Dust diseases and the legacy of corporate manipulation of science and law
D. Egilman (2014)
From the Australian Institute of Health and Welfare
G. Fitzsimmons (2002)
The debate on banning asbestos. CMAJ
L. Kazan-Allen (2001)
The ticking time-bomb of asbestos: its insidious role in the development of malignant mesothelioma.
Anthony Linton (2012)
Germline BAP1 Mutational Landscape of Asbestos-Exposed Malignant Mesothelioma Patients with Family History of Cancer.
J. Ohar (2016)
Chrysotile, tremolite and fibrogenicity.
J. C. Mcdonald (1999)
Available from: www
The asbestos fibre burden in human lungs: new insights into the chrysotile debate
I. Feder (2017)
Mesothelioma Associated with the Use of Cosmetic Talc.
J. Moline (2019)
Estimating the incidence of malignant mesothelioma in Vietnam: a pilot descriptive cancer registration study
M. Soeberg (2016)
[Professional risk factors associated with the cancer of the ovary. Literature review].
A. Bounin (2014)
[Risk factors of lung cancer].
L. P. Ger (1992)
Experience of Japan in Achieving a Total Ban on Asbestos
S. Furuya (2017)
Assessment of the future mesothelioma disease burden from past exposure to asbestos in ship recycling yards in India.
R. Singh (2020)
Mortality and mesothelioma incidence among chrysotile asbestos miners in Balangero, Italy: A cohort study.
D. Ferrante (2019)
Mesothelioma families without inheritance of a BAP1 predisposing mutation.
V. Ascoli (2016)
The worldwide pandemic of asbestos-related diseases.
L. Stayner (2013)
Call for an international ban on asbestos.
C. Maltoni (1999)
The Biopersistence of Canadian Chrysotile Asbestos Following Inhalation: Final Results Through 1 Year After Cessation of Exposure
D. Bernstein (2005)
Pleural mesothelioma and occupational and non-occupational asbestos exposure: a case-control study with quantitative risk assessment
D. Ferrante (2015)
Oral and pharyngeal cancer risk associated with occupational carcinogenic substances: Systematic review
K. Awan (2018)
Doubt Is Their Product: How Industry’s Assault on Science Threatens Your Health
S. G. Gilbert (2009)
Saving the asbestos
J. McCulloch (1960)
• Carefully executed epidemiological study estimating the consequences of residential asbestos exposure in Australia
Cumulative asbestos exposure and mortality from asbestos related diseases in a pooled analysis of 21 asbestos cement cohorts in Italy
F. Luberto (2019)
Challenges and controversies in the diagnosis of mesothelioma: Part 1. Cytology-only diagnosis, biopsies, immunohistochemistry, discrimination between mesothelioma and reactive mesothelial hyperplasia, and biomarkers
D. Henderson (2013)
After Helsinki: a multidisciplinary review of the relationship between asbestos exposure and lung cancer, with emphasis on studies published during 1997-2004.
D. Henderson (2004)
The Asbestos War
L. Kazan-Allen (2003)
BAP1, a tumor suppressor gene driving malignant mesothelioma.
M. Cheung (2017)
Improving the Accuracy of Mesothelioma Diagnosis in China.
M. Carbone (2017)
International agency for research on cancer.
J. Higginson (1974)
National survey of malignant mesothelioma and asbestos exposure in Japan
K. Gemba (2012)
Environmental asbestos exposure in childhood and risk of mesothelioma later in life: a long-term follow-up register-based cohort study
S. B. Dalsgaard (2019)
IARC in the dock over ties with asbestos industry
D. Holmes (2013)
Lung cancer risk at low cumulative asbestos exposure: meta-regression of the exposure–response relationship
S. V. D. Bij (2012)
Comments on the 2014 helsinki consensus report on asbestos
C. Ramazzini (2016)
The global spread of asbestos.
Arthur L. Frank (2014)
Asbestos - the Future Risk
B Hadley (2013)
Ban Asbestos Phenomenon: The Winds of Change
L. Kazan-Allen (2011)
Facteurs de risques professionnels du cancer de l’ovaire. Revue de la littérature
A. Bounin (2014)
Asbestos in Asia
Su Lyn Leong (2015)
The Asbestos Ban in Korea from a Grassroots Perspective: Why Did It Occur?
Yu-Ryong Yoon (2018)
Cancer incidence and mortality patterns in Europe: estimates for 40 countries
J Ferlay (2012)
Ecological association between asbestos-related diseases and historical asbestos consumption: an international analysis
Ro-Ting Lin (2007)
The 18th Collegium Ramazzini statement: The global health dimensions of asbestos and asbestos-related diseases.
C. Ramazzini (2016)
How conflicted authors undermine the World Health Organization (WHO) campaign to stop all use of asbestos: spotlight on studies showing that chrysotile is carcinogenic and facilitates other non-cancer asbestos-related diseases
X. Baur (2015)
UN Scientific Agency collaborating with scientists involved in sabotaging UN Rotterdam Convention
K. Ruff (2013)
Exposure–Response Analyses of Asbestos and Lung Cancer Subtypes in a Pooled Analysis of Case–Control Studies
A. Olsson (2017)
The debate on banning asbestos.
L. Kazan-Allen (2001)
The epidemiology of asbestos-related diseases.
J. Nikliński (2004)
Asbestos Is Still With Us: Repeat Call for a Universal Ban
C. Ramazzini (2010)
Asbestos in commercial indian talc
S. Fitzgerald (2019)
Update of Potency Factors for Asbestos-Related Lung Cancer and Mesothelioma
D. Berman (2008)
• Important update of the consequences of asbestos exposre in the occupational and the environmental setting in Casale Monferrato (asbestos cement plant), a very well
Environmental asbestos exposure and risk of mesothelioma.
C. Noonan (2017)
Asbestos‐associated genome‐wide DNA methylation changes in lung cancer
E. Kettunen (2017)
Risk of cancer associated with residential exposure to asbestos insulation: a whole-population cohort study.
R. Korda (2017)
Barriers and Facilitators to the Elimination of Asbestos Related Diseases—Stakeholders’ Perspectives
J. Vincenten (2017)
Asbestos, asbestosis, and cancer: the Helsinki criteria for diagnosis and attribution.
A. Tossavainen (1997)
Exposing and addressing tobacco industry conduct in low-income and middle-income countries
A. Gilmore (2015)
[Environmental exposure to asbestos in the area around Goor has been established as the cause of pleural mesothelioma in women].
H. E. Sinninghe Damsté (2007)
Non‐asbestos‐related malignant mesothelioma. A review
J. T. Peterson (1984)
Pleural mesothelioma and asbestos exposure: a case–control study with quantitative risk assessment—response to Marsh and Benson's letter
D. Ferrante (2016)
Occupational exposure to chrysotile asbestos and cancer risk: a review of the amphibole hypothesis.
L. Stayner (1996)
Asbestos, Smoking and Lung Cancer: An Update
S. Klebe (2019)
Genetic predisposition for malignant mesothelioma: A concise review.
M. Betti (2019)
The first review of over 100 epidemiological studies dating back to one of the first reported cases of asbestos-related disease
Pleural Mesothelioma in a Woman Whose Documented Past Exposure to Asbestos was From Smoking Asbestos-Containing Filtered Cigarettes: The Comparative Value of Analytical Transmission Electron Microscopic Analysis of Lung and Lymph-Node Tissue
R. Dodson (2006)
Chrysotile, tremolite and carcinogenicity.
J. C. Mcdonald (1997)
Global Magnitude of Reported and Unreported Mesothelioma
Eun-Kee Park (2011)
Mortality in chrysotile asbestos workers in China
X. Wang (2013)
Saving the asbestos industry
J Mcculloch (1960)
Asbestos and the Pathophysiology of Mesothelioma
Nico van Zandwijk (2019)
Radiation‐induced mesothelioma among long‐term solid cancer survivors: a longitudinal analysis of SEER database
A. Farioli (2016)
Exposure-response analysis of risk of respiratory disease associated with occupational exposure to chrysotile asbestos.
L. Stayner (1997)
Does Exposure to Asbestos Cause Ovarian Cancer? A Systematic Literature Review and Meta-analysis
A. Reid (2011)
Malignant mesothelioma in Australia 2015: Current incidence and asbestos exposure trends
M. Soeberg (2016)
Occupational asbestos exposure and risk of esophageal, gastric and colorectal cancer in the prospective Netherlands Cohort Study
Nadine S M Offermans (2014)
The Tale of Asbestos in Sweden 1972–1986—The Pathway to a Near-Total Ban
P. Westerholm (2017)
How Canada Changed from Exporting Asbestos to Banning Asbestos: The Challenges That Had to Be Overcome
K. Ruff (2017)
Saving the Asbestos Industry, 1960 TO 2006
J. Mcculloch (2006)
• The first call for an international ban on asbestos by a distinguished group of scientists, clearly stating that all forms of asbestos should be banned
Lung cancer mortality from exposure to chrysotile asbestos and smoking: a case–control study within a cohort in China
E. Yano (2010)
Criminality and Asbestos in Industry
B. Castleman (2017)
Current Asbestos Exposure and Future Need for Palliative Care in India
A. Jadhav (2019)
Impact of an asbestos cement factory on mesothelioma incidence in a community in Italy.
D. Consonni (2019)
Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012.
J. Ferlay (2013)
Risk factors for lung cancer worldwide
J. Malhotra (2016)
A 37-year observation of mortality in Chinese chrysotile asbestos workers
X. Wang (2011)
Milieublootstelling aan asbest in de regio Goor vastgesteld als oorzaak van maligne pleuramesothelioom bij vrouwen
H. E. J. S. Damsté (2007)
Joint Policy Committee of Epidemiology Societies. Position statement on asbestos
This paper is referenced by
A potential cause of asbestos-related granulomatosis due to adulterant contamination in a drug abuser
Maria Concetta Lazzaro (2020)